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Research ArticleCase Report

Seronegative Polyarthritis in Association With Anti-NXP2 Antibodies: A Case Series

Aurélie Mourot, Josiane Bourré-Tessier, Valérie Nadon and Océane Landon-Cardinal
The Journal of Rheumatology January 2023, 50 (1) 153-155; DOI: https://doi.org/10.3899/jrheum.220248
Aurélie Mourot
1Division of Internal Medicine, Centre hospitalier de l’Université de Montréal (CHUM), Department of Medicine, Université de Montréal;
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  • For correspondence: aurelie.mourot@umontreal.ca
Josiane Bourré-Tessier
2Division of Rheumatology, Centre hospitalier de l’Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal;
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Valérie Nadon
3Division of Rheumatology, Hôpital Notre-Dame, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
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Océane Landon-Cardinal
2Division of Rheumatology, Centre hospitalier de l’Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal;
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REFERENCES

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    1. Satoh M,
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    Assessment of diagnostic utility, clinical phenotypic associations, and prognostic significance of anti-NXP2 autoantibody in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis. Clin Rheumatol 2021;40:819-32.
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    Clinical and serological characterization of the anti-MJ antibody in childhood myositis [abstract]. Arthritis Rheum 1997;40:S139.
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    1. Kimura Y,
    2. Sakai F,
    3. Nakano O, et al.
    The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. J Biol Chem 2002;277:20611-7.
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    1. Espada G,
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    3. Fertig N,
    4. Oddis CV.
    Clinical and serologic characterization of an Argentine pediatric myositis cohort: identification of a novel autoantibody (anti-MJ) to a 142-kDa protein. J Rheumatol 2009;36:2547-51.
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    1. Platteel ACM,
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    Four dermatomyositis-specific autoantibodies-anti-TIF1γ, anti-NXP2, anti-SAE and anti-MDA5-in adult and juvenile patients with idiopathic inflammatory myopathies in a Hungarian cohort. Autoimmun Rev 2014;13:1211-9.
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    1. Tansley SL,
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    The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity. Rheumatology 2020;59:2109-14.
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    1. Fiorentino DF,
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    Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ. Arthritis Rheum 2013;65:2954-62.
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Seronegative Polyarthritis in Association With Anti-NXP2 Antibodies: A Case Series
Aurélie Mourot, Josiane Bourré-Tessier, Valérie Nadon, Océane Landon-Cardinal
The Journal of Rheumatology Jan 2023, 50 (1) 153-155; DOI: 10.3899/jrheum.220248

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Seronegative Polyarthritis in Association With Anti-NXP2 Antibodies: A Case Series
Aurélie Mourot, Josiane Bourré-Tessier, Valérie Nadon, Océane Landon-Cardinal
The Journal of Rheumatology Jan 2023, 50 (1) 153-155; DOI: 10.3899/jrheum.220248
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