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Research ArticleOriginal Research

What Constitutes a Positive MRI for Clinical Trial Recruitment of Psoriatic Arthritis Patients With Axial Involvement?

Walter P. Maksymowych and Mikkel Østergaard
The Journal of Rheumatology June 2022, 49 (6 Suppl 1) 72-74; DOI: https://doi.org/10.3899/jrheum.211340
Walter P. Maksymowych
1W.P. Maksymowych, FRCPC, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada;
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  • For correspondence: walter.maksymowych@ualberta.ca
Mikkel Østergaard
2M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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Abstract

There has been a resurgence of interest in defining the axial inflammation component of psoriatic arthritis (PsA) since recent randomized controlled trials (RCTs) raised the possibility that this entity may respond differentially to therapeutics compared to patients with axial spondyloarthritis. A workshop was conducted during the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis annual meeting to review the literature on diagnosing PsA and to determine which criteria might be most appropriate. There was quite strong agreement that magnetic resonance imaging (MRI) had an important role to play in helping to define axial inflammation in PsA and that a data-driven methodology for generating optimal MRI quantitative cut-offs for lesions in the sacroiliac joints and/or spine that reflect imaging typical of axial inflammation in PsA would be most desirable.

Key Indexing Terms:
  • GRAPPA
  • inflammation
  • MRI
  • psoriasis
  • psoriatic arthritis
  • spine
  • Accepted for publication December 9, 2021.
  • Copyright © 2022 by The Journal of Rheumatology
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The Journal of Rheumatology
Vol. 49, Issue 6 Suppl 1
1 Jun 2022
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What Constitutes a Positive MRI for Clinical Trial Recruitment of Psoriatic Arthritis Patients With Axial Involvement?
Walter P. Maksymowych, Mikkel Østergaard
The Journal of Rheumatology Jun 2022, 49 (6 Suppl 1) 72-74; DOI: 10.3899/jrheum.211340

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What Constitutes a Positive MRI for Clinical Trial Recruitment of Psoriatic Arthritis Patients With Axial Involvement?
Walter P. Maksymowych, Mikkel Østergaard
The Journal of Rheumatology Jun 2022, 49 (6 Suppl 1) 72-74; DOI: 10.3899/jrheum.211340
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Keywords

GRAPPA
INFLAMMATION
MRI
PSORIASIS
PSORIATIC ARTHRITIS
SPINE

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  • GRAPPA Treatment Recommendations: 2021 Update
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Keywords

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  • psoriasis
  • psoriatic arthritis
  • spine

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