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Research ArticleSystemic Lupus Erythematosus

High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis

Taro Iwamoto, Jessica M. Dorschner, Shanmugapriya Selvaraj, Valeria Mezzano, Mark A. Jensen, Danielle Vsetecka, Shreyasee Amin, Ashima Makol, Thomas Osborn, Kevin Moder, Vaidehi R. Chowdhary, Peter Izmirly, H. Michael Belmont, Robert M. Clancy, Jill P. Buyon, Ming Wu, Cynthia A. Loomis and Timothy B. Niewold
The Journal of Rheumatology April 2022, 49 (4) 388-397; DOI: https://doi.org/10.3899/jrheum.210391
Taro Iwamoto
1T. Iwamoto, MD, PhD, Colton Center for Autoimmunity, New York University, New York, New York, USA, and Allergy and Clinical Immunology, Chiba University, Japan;
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  • ORCID record for Taro Iwamoto
Jessica M. Dorschner
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Shanmugapriya Selvaraj
3S. Selvaraj, MS, V. Mezzano, MD, PhD, M. Wu, MD, C.A. Loomis, MD, PhD, Department of Pathology, New York University, New York, New York, USA;
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Valeria Mezzano
3S. Selvaraj, MS, V. Mezzano, MD, PhD, M. Wu, MD, C.A. Loomis, MD, PhD, Department of Pathology, New York University, New York, New York, USA;
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Mark A. Jensen
4M.A. Jensen, PhD, R.M. Clancy, PhD, J.P. Buyon, MD, T.B. Niewold, MD, Colton Center for Autoimmunity, New York University, New York, New York, USA;
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Danielle Vsetecka
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Shreyasee Amin
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Ashima Makol
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Thomas Osborn
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Kevin Moder
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Vaidehi R. Chowdhary
2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
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Peter Izmirly
5P. Izmirly, MD, H.M. Belmont, MD, Division of Rheumatology, New York University, New York, New York, USA.
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H. Michael Belmont
5P. Izmirly, MD, H.M. Belmont, MD, Division of Rheumatology, New York University, New York, New York, USA.
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Robert M. Clancy
4M.A. Jensen, PhD, R.M. Clancy, PhD, J.P. Buyon, MD, T.B. Niewold, MD, Colton Center for Autoimmunity, New York University, New York, New York, USA;
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Jill P. Buyon
4M.A. Jensen, PhD, R.M. Clancy, PhD, J.P. Buyon, MD, T.B. Niewold, MD, Colton Center for Autoimmunity, New York University, New York, New York, USA;
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Ming Wu
3S. Selvaraj, MS, V. Mezzano, MD, PhD, M. Wu, MD, C.A. Loomis, MD, PhD, Department of Pathology, New York University, New York, New York, USA;
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Cynthia A. Loomis
3S. Selvaraj, MS, V. Mezzano, MD, PhD, M. Wu, MD, C.A. Loomis, MD, PhD, Department of Pathology, New York University, New York, New York, USA;
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Timothy B. Niewold
4M.A. Jensen, PhD, R.M. Clancy, PhD, J.P. Buyon, MD, T.B. Niewold, MD, Colton Center for Autoimmunity, New York University, New York, New York, USA;
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  • For correspondence: Timothy.Niewold@nyulangone.org
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Article Information

vol. 49 no. 4 388-397
DOI 
https://doi.org/10.3899/jrheum.210391
PubMed 
34782453

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication November 3, 2021
  • Published online April 1, 2022.

Article Versions

  • Latest version (November 15, 2021 - 04:00).
  • Latest version (February 1, 2022 - 04:00).
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Copyright & Usage 
Copyright © 2022 by the Journal of Rheumatology

Author Information

  1. Taro Iwamoto1,
  2. Jessica M. Dorschner2,
  3. Shanmugapriya Selvaraj3,
  4. Valeria Mezzano3,
  5. Mark A. Jensen4,
  6. Danielle Vsetecka2,
  7. Shreyasee Amin2,
  8. Ashima Makol2,
  9. Thomas Osborn2,
  10. Kevin Moder2,
  11. Vaidehi R. Chowdhary2,
  12. Peter Izmirly5,
  13. H. Michael Belmont5,
  14. Robert M. Clancy4,
  15. Jill P. Buyon4,
  16. Ming Wu3,
  17. Cynthia A. Loomis3 and
  18. Timothy B. Niewold4⇑
  1. 1T. Iwamoto, MD, PhD, Colton Center for Autoimmunity, New York University, New York, New York, USA, and Allergy and Clinical Immunology, Chiba University, Japan;
  2. 2J.M. Dorschner, BS, D. Vsetecka, MPH, S. Amin, MD, A. Makol, MD, T. Osborn, MD, K. Moder, MD, V.R. Chowdhary, MD, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;
  3. 3S. Selvaraj, MS, V. Mezzano, MD, PhD, M. Wu, MD, C.A. Loomis, MD, PhD, Department of Pathology, New York University, New York, New York, USA;
  4. 4M.A. Jensen, PhD, R.M. Clancy, PhD, J.P. Buyon, MD, T.B. Niewold, MD, Colton Center for Autoimmunity, New York University, New York, New York, USA;
  5. 5P. Izmirly, MD, H.M. Belmont, MD, Division of Rheumatology, New York University, New York, New York, USA.
  1. Address correspondence to Dr. T.B. Niewold, Colton Center for Autoimmunity, NYU Grossman School of Medicine, 550 1st Ave., New York, NY 10016, USA. Email: Timothy.Niewold{at}nyulangone.org.

Article usage

Article usage: November 2021 to July 2022

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Nov 2021726031
Dec 2021352025
Jan 2022259015
Feb 2022339010
Mar 20222591019
Apr 202216553142
May 20227711712
Jun 20228291213
Jul 2022476148

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High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis
Taro Iwamoto, Jessica M. Dorschner, Shanmugapriya Selvaraj, Valeria Mezzano, Mark A. Jensen, Danielle Vsetecka, Shreyasee Amin, Ashima Makol, Thomas Osborn, Kevin Moder, Vaidehi R. Chowdhary, Peter Izmirly, H. Michael Belmont, Robert M. Clancy, Jill P. Buyon, Ming Wu, Cynthia A. Loomis, Timothy B. Niewold
The Journal of Rheumatology Apr 2022, 49 (4) 388-397; DOI: 10.3899/jrheum.210391

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High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis
Taro Iwamoto, Jessica M. Dorschner, Shanmugapriya Selvaraj, Valeria Mezzano, Mark A. Jensen, Danielle Vsetecka, Shreyasee Amin, Ashima Makol, Thomas Osborn, Kevin Moder, Vaidehi R. Chowdhary, Peter Izmirly, H. Michael Belmont, Robert M. Clancy, Jill P. Buyon, Ming Wu, Cynthia A. Loomis, Timothy B. Niewold
The Journal of Rheumatology Apr 2022, 49 (4) 388-397; DOI: 10.3899/jrheum.210391
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Keywords

interferon signature gene
LUPUS NEPHRITIS
podocyte injury type I interferon

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