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Research ArticlePediatric Rheumatology

Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome

Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng and Linda T. Hiraki
The Journal of Rheumatology October 2022, 49 (10) 1146-1151; DOI: https://doi.org/10.3899/jrheum.211200
Piya Lahiry
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Piya Lahiry
Sergey Naumenko
2S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids;
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  • ORCID record for Sergey Naumenko
Madeline Couse
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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Fangming Liao
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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Daniela Dominguez
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Daniela Dominguez
Andrea Knight
4A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids;
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  • ORCID record for Andrea Knight
Deborah M. Levy
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Deborah M. Levy
Melissa Misztal
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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  • ORCID record for Melissa Misztal
Lawrence W.K. Ng
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Lawrence W.K. Ng
Linda T. Hiraki
5L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada.
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  • For correspondence: linda.hiraki@sickkids.ca
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The Journal of Rheumatology
Vol. 49, Issue 10
1 Oct 2022
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Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Oct 2022, 49 (10) 1146-1151; DOI: 10.3899/jrheum.211200

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Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Oct 2022, 49 (10) 1146-1151; DOI: 10.3899/jrheum.211200
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Keywords

GENETIC STUDIES
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
MACROPHAGE ACTIVATION SYNDROME
PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
whole-exome sequencing
whole-genome sequencing

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Keywords

  • genetic studies
  • hemophagocytic lymphohistiocytosis
  • macrophage activation syndrome
  • pediatric systemic lupus erythematosus
  • whole-exome sequencing
  • whole-genome sequencing

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