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Research ArticlePediatric Rheumatology

Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome

Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng and Linda T. Hiraki
The Journal of Rheumatology October 2022, 49 (10) 1146-1151; DOI: https://doi.org/10.3899/jrheum.211200
Piya Lahiry
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Piya Lahiry
Sergey Naumenko
2S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids;
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  • ORCID record for Sergey Naumenko
Madeline Couse
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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Fangming Liao
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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Daniela Dominguez
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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  • ORCID record for Daniela Dominguez
Andrea Knight
4A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids;
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  • ORCID record for Andrea Knight
Deborah M. Levy
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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Melissa Misztal
3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
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  • ORCID record for Melissa Misztal
Lawrence W.K. Ng
1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
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Linda T. Hiraki
5L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada.
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  • For correspondence: linda.hiraki@sickkids.ca
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Article Information

vol. 49 no. 10 1146-1151
DOI 
https://doi.org/10.3899/jrheum.211200
PubMed 
35649546

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication May 20, 2022
  • Published online October 1, 2022.

Article Versions

  • Latest version (June 1, 2022 - 04:00).
  • Latest version (August 1, 2022 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2022 by the Journal of Rheumatology

Author Information

  1. Piya Lahiry1,
  2. Sergey Naumenko2,
  3. Madeline Couse3,
  4. Fangming Liao3,
  5. Daniela Dominguez1,
  6. Andrea Knight4,
  7. Deborah M. Levy1,
  8. Melissa Misztal3,
  9. Lawrence W.K. Ng1 and
  10. Linda T. Hiraki5⇑
  1. 1P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids;
  2. 2S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids;
  3. 3M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids;
  4. 4A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids;
  5. 5L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada.
  1. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki{at}sickkids.ca.

Article usage

Article usage: May 2022 to February 2023

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Jun 2022448017
Jul 2022201015
Aug 202255807
Sep 20222861516
Oct 202215568229
Nov 2022538139
Dec 2022489203
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Vol. 49, Issue 10
1 Oct 2022
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Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Oct 2022, 49 (10) 1146-1151; DOI: 10.3899/jrheum.211200

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Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Oct 2022, 49 (10) 1146-1151; DOI: 10.3899/jrheum.211200
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Keywords

GENETIC STUDIES
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
MACROPHAGE ACTIVATION SYNDROME
PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
whole-exome sequencing
whole-genome sequencing

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Keywords

  • genetic studies
  • hemophagocytic lymphohistiocytosis
  • macrophage activation syndrome
  • pediatric systemic lupus erythematosus
  • whole-exome sequencing
  • whole-genome sequencing

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