Mechanic’s hand is a representative manifestation of antisynthetase syndrome (AS) but is observed in other forms of dermatomyositis1. This is a nonpruritic, hyperkeratotic, and scaly eruption on the ulnar side of the thumb and radial side of other fingers; occasionally the palms, fingertips, and feet are involved. However, a widespread type affecting the whole palm and fingers is extremely rare in anti-OJ antibody.
A 66-year-old farmer was admitted with fever, cough, and eczema-like eruptions on the hands (Figure 1). Six months before admission, he received a course of methylprednisolone pulse therapy for interstitial lung disease, and his symptoms improved. A skin rash developed on both hands during the period of prednisolone (PSL) reduction to 10 mg/day. When he was admitted, scaly hyperkeratosis was noted on each finger and on the lateral side and palm surface of both hands (Figure 1A). Skin biopsy revealed irregular acanthosis accompanied by hyperkeratosis and mild spongiosis (Figure 1C). Liquefaction degeneration and mucin deposition were not observed. Laboratory findings showed elevated muscle enzyme levels. Anti-OJ antibodies were identified by RNA and protein immunoprecipitation assays from the patient’s serum2. Computed tomography showed a reticular shadow in the lower lung fields, consistent with AS. His symptoms improved with a course of methylprednisolone pulse therapy and 30 mg/day of PSL. (Figure 1B). We considered his hand lesions as mechanic’s hands. The skin biopsy findings were mostly compatible with those reported in a previous report3. In addition, his mechanic’s hands was associated with disease activity.
Footnotes
The authors declare no conflicts of interest with regard to this work. The Ethics Committee of Toyama University Hospital approved this case report for submission (ethics approval number: E2020002). The patient gave written informed consent to publish the material.
- © 2021 The Journal of Rheumatology