Article Figures & Data
Figures
- Figure 1.
Expression of IFN-inducible gene expression upon treatment with hydroxychloroquine. Relative expression (RE) of IFN-inducible genes (A) LY6E, (B) MX1, (C) IFI44L, and (D) IFN-3 score, before and after treatment with HCQ. The level of significance (P value) is depicted. All patients are labeled by their subject numbers (see Table 1.) The dotted line represents the mean ± SD of the healthy controls. HCQ: hydroxychloroquine; IFN: interferon.
- Figure 2.
Change of IFN-related mediators and SLEDAI after treatment with HCQ. Levels of (A) B cell activating factor (BAFF), (B) IFN-γ–induced protein 10 (IP-10), and (C) SLEDAI, before and after treatment with HCQ. The level of significance (P value) is depicted. All patients are labelled by their subject numbers (see Table 1.) HCQ: hydroxychloroquine; IFN: interferon; SLEDAI: Systemic Lupus Erythematosus Disease Activity Index.
Tables
1 2 3 4 5 6 7 8 9 Reason for HCQ start Tendinitis Arthritis Arthritis Arthritis Arthritis Arthritis Arthritis CLE Arthritis Sex F F M F M M F M F Age, yrs 29 26 68 55 56 41 30 37 59 Disease duration, mos 2 3 9 6 21 3 24 13 12 Simultaneous start of NSAID No Yes Yes No No Yes Yes No Yes No. ACR criteria 3 3 3 2 4 2 3 3 3 No. SLICC criteria 2 3 3 2 4 3 4 3 3 Sum score, EULAR/ACR criteria 17 13 12 6 16 8 9 10 8 Clinical criteria Skin – x – – – – x x – Ulcers – – – – – – – – – Synovitis – – x x x x x – x Hematologic x – – – – – – – – Serositis – – – – x – – – – Renal – – – – – – – – – Neurologic – – – – – – – – – Immunologic criteria ANA x x x x x x x x x Anti-dsDNA x – x – – – – x – Anti-SSA x – – x – – – x – Anti-Sm – x – – – – – – – Anti-RNP1 – x – – – – – – – Low complement – – – – – – x – – Antiphospholipids – – – – x x – – x HCQ serum level, μg/L 628 147 342 564 315 233 258 129 496 Resolution of symptoms No No No No Yes Yes No Yes Yes SLEDAI before HCQspecified 0 4a 6a,b 4a 6a,c 4a 6a,c 2d 4a SLEDAI after HCQspecified 0 1e 2b 4a 0 0 2c 2d 0 Specification of SLEDAI score:
↵aarthritis (4 points);
↵banti-dsDNA (2 points);
↵clow complement 3 or 4 (2 points);
↵dskin rash (2 points);
↵eleukopenia (1 point). ACR: American College of Rheumatology; ANA: antinuclear antibody; CLE: cutaneous lupus erythematosus; EULAR; European League Against Rheumatism; HCQ: hydroxychloroquine; NSAID: nonsteroidal antiinflammatory drug; SLICC: SLE International Collaborating Clinics; SLEDAI: Systemic Lupus Erythematosus Disease Activity Index.
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