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Research ArticleSystemic Lupus Erythematosus

Lupus Low Disease Activity State Achievement Is Important for Reducing Adverse Outcomes in Pregnant Patients With Systemic Lupus Erythematosus

Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Jeong I. Yang, Dong W. Kwak and Chang-Hee Suh
The Journal of Rheumatology May 2021, 48 (5) 707-716; DOI: https://doi.org/10.3899/jrheum.200802
Ji-Won Kim
1J.W. Kim, MD, J.Y. Jung, MD, PhD, H.A. Kim, MD, PhD, C.H. Suh, MD, PhD, Department of Rheumatology, Ajou University School of Medicine, Suwon;
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Ju-Yang Jung
1J.W. Kim, MD, J.Y. Jung, MD, PhD, H.A. Kim, MD, PhD, C.H. Suh, MD, PhD, Department of Rheumatology, Ajou University School of Medicine, Suwon;
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Hyoun-Ah Kim
1J.W. Kim, MD, J.Y. Jung, MD, PhD, H.A. Kim, MD, PhD, C.H. Suh, MD, PhD, Department of Rheumatology, Ajou University School of Medicine, Suwon;
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Jeong I. Yang
2J.I. Yang, MD, PhD, D.W. Kwak, MD, PhD, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
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Dong W. Kwak
2J.I. Yang, MD, PhD, D.W. Kwak, MD, PhD, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
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Chang-Hee Suh
1J.W. Kim, MD, J.Y. Jung, MD, PhD, H.A. Kim, MD, PhD, C.H. Suh, MD, PhD, Department of Rheumatology, Ajou University School of Medicine, Suwon;
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  • For correspondence: chsuh@ajou.ac.kr
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REFERENCES

  1. 1.↵
    1. Kalok A,
    2. Cader RA,
    3. Indirayani I,
    4. Karim AKA,
    5. Shah SA,
    6. Ismail NAM, et al.
    Pregnancy outcomes in systemic lupus erythematosus (SLE) women. Horm Mol Biol Clin Investig 2019;40:1868-91.
    OpenUrl
  2. 2.↵
    1. Petri M,
    2. Kallas R.
    Lupus in pregnancy. Contemp Ob Gyn 2019;64 No 03. [Internet. Accessed January 21, 2021.] Available from: www.contemporaryobgyn.net/pregnancy-and-birth/lupus-pregnancy
  3. 3.↵
    1. Lionaki S
    1. Ordi-Ros J,
    2. Marce CS,
    3. Cortes-Hernandez J.
    Lupus pregnancy: risk factors and management. In: Lionaki S, ed. Lupus – new advances and challenges. [Internet. Accessed February 8, 2021.] Available from: www.intechopen.com/books/lupus-new-advances-and-challenges/lupus-pregnancy-risk-factors-and-management
  4. 4.↵
    1. Wallace D,
    2. Hahn B.
    1. Chakravarty EF,
    2. Sammaritano LR.
    Pregnancy and autoimmune disease, reproductive and hormonal issues. In: Wallace D, Hahn B. Dubois’ lupus erythematosus and related syndromes 9th ed. Elsevier; 2019:499-519.
  5. 5.↵
    1. Petri M,
    2. Howard D,
    3. Repke J.
    Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience. Arthritis Rheum 1991;34:1538-45.
    OpenUrlPubMed
  6. 6.↵
    1. Chakravarty EF,
    2. Colón I,
    3. Langen ES,
    4. Nix DA,
    5. El-Sayed YY,
    6. Genovese MC, et al.
    Factors that predict prematurity and preeclampsia in pregnancies that are complicated by systemic lupus erythematosus. Am J Obstet Gynecol 2005;192:1897-904.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Buyon JP,
    2. Kim MY,
    3. Salmon JE.
    Predictors of pregnancy outcomes in patients with lupus. Ann Intern Med 2016;164:131.
    OpenUrl
  8. 8.↵
    1. Jones A,
    2. Giles I.
    Fertility and pregnancy in systemic lupus erythematosus. Indian J Rheumatol 2016;11 Suppl S2:128-34.
    OpenUrl
  9. 9.↵
    1. Wu J,
    2. Ma J,
    3. Zhang W-H,
    4. Di W.
    Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis. Ther Clin Risk Manag 2018;14:885-901.
    OpenUrl
  10. 10.↵
    1. Moroni G,
    2. Ponticelli C.
    Pregnancy in women with systemic lupus erythematosus (SLE). Eur J Intern Med 2016;32:7-12.
    OpenUrl
  11. 11.↵
    1. Smyth A,
    2. Oliveira GHM,
    3. Lahr BD,
    4. Bailey KR,
    5. Norby SM,
    6. Garovic VD.
    A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol 2010;5:2060-8.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Jordan N.
    Management of pregnancy in systemic lupus erythematosus: what a GP should know. Lupus 2018;27:40-3.
    OpenUrl
  13. 13.↵
    1. van Vollenhoven RF,
    2. Mosca M,
    3. Bertsias G,
    4. Isenberg D,
    5. Kuhn A,
    6. Lerstrøm K, et al.
    Treat-to-target in systemic lupus erythematosus: recommendations from an international task force. Ann Rheum Dis 2014;73:958-67.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Franklyn K,
    2. Lau CS,
    3. Navarra SV,
    4. Louthrenoo W,
    5. Lateef A,
    6. Hamijoyo L, et al.
    Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). Ann Rheum Dis 2016;75:1615-21.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Hochberg MC.
    Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Petri M,
    2. Orbai A-M,
    3. Alarcón GS,
    4. Gordon C,
    5. Merrill JT,
    6. Fortin PR, et al.
    Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677-86.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Gladman DD,
    2. Ibañez D,
    3. Urowitz MB.
    Systemic Lupus Erythematosus Disease Activity Index 2000. J Rheumatol 2002;29:288-91.
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Clark CA,
    2. Spitzer KA,
    3. Laskin CA.
    Decrease in pregnancy loss rates in patients with systemic lupus erythematosus over a 40-year period. J Rheumatol 2005;32:1709-12.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Moroni G,
    2. Doria A,
    3. Giglio E,
    4. Imbasciati E,
    5. Tani C,
    6. Zen M, et al.
    Maternal outcome in pregnant women with lupus nephritis. A prospective multicenter study. J Autoimmun 2016;74:194-200.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Moroni G,
    2. Doria A,
    3. Giglio E,
    4. Tani C,
    5. Zen M,
    6. Strigini F, et al.
    Fetal outcome and recommendations of pregnancies in lupus nephritis in the 21st century. A prospective multicenter study. J Autoimmun 2016;74:6-12.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Nahal SK,
    2. Selmi C,
    3. Gershwin ME.
    Safety issues and recommendations for successful pregnancy outcome in systemic lupus erythematosus. J Autoimmun 2018;93:16-23.
    OpenUrl
  22. 22.↵
    1. Zhan Z,
    2. Yang Y,
    3. Zhan Y,
    4. Chen D,
    5. Liang L,
    6. Yang X.
    Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus. PLoS One 2017;12:e0176457.
    OpenUrl
  23. 23.↵
    1. Kim MY,
    2. Buyon JP,
    3. Guerra MM,
    4. Rana S,
    5. Zhang D,
    6. Laskin CA, et al.
    Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. Am J Obstet Gynecol 2016;214:108.e1-108.e14.
    OpenUrlCrossRef
  24. 24.↵
    1. Shin JH,
    2. Lee EY,
    3. Lee CK,
    4. Cho YS,
    5. Kim A,
    6. Yoo B, et al.
    Fetal outcome and clinical feature during pregnancy in systemic lupus erythematosus. Korean J Med 2003;65:511-9.
    OpenUrl
  25. 25.↵
    1. Ahn HY,
    2. Kim YH,
    3. Kil KC,
    4. Park IY,
    5. Lee G,
    6. Kim SJ, et al.
    Clinical course and obstetrical outcomes of 94 pregnancies in Korean patients with systemic lupus erythematosus (SLE). Korean J Obstet Gynecol 2008;51:147-57.
    OpenUrl
  26. 26.↵
    1. Park EJ,
    2. Jung H,
    3. Hwang J,
    4. Kim H,
    5. Lee J,
    6. Ahn JK, et al.
    Pregnancy outcomes in patients with systemic lupus erythematosus: a retrospective review of 62 pregnancies at a single tertiary center in South Korea. Int J Rheum Dis 2014;17:887-97.
    OpenUrl
  27. 27.↵
    1. Ko HS,
    2. Ahn HY,
    3. Jang DG,
    4. Choi S-K,
    5. Park Y-G,
    6. Park IY, et al.
    Pregnancy outcomes and appropriate timing of pregnancy in 183 pregnancies in Korean patients with SLE. Int J Med Sci 2011; 8:577-83.
    OpenUrlPubMed
  28. 28.↵
    1. Sugawara E,
    2. Kato M,
    3. Fujieda Y,
    4. Oku K,
    5. Bohgaki T,
    6. Yasuda S, et al.
    Pregnancy outcomes in women with rheumatic diseases: a real-world observational study in Japan. Lupus 2019;28:1407-16.
    OpenUrl
  29. 29.↵
    1. Clowse ME,
    2. Jamison M,
    3. Myers E,
    4. James AH.
    A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol 2008;199:127.e1-e6.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Chen YJ,
    2. Chang JC,
    3. Lai EL,
    4. Liao TL,
    5. Chen HH,
    6. Hung WT, et al.
    Maternal and perinatal outcomes of pregnancies in systemic lupus erythematosus: a nationwide population-based study. Semin Arthritis Rheum 2020;50:451-57.
    OpenUrl
  31. 31.↵
    1. Dhar JP,
    2. Essenmacher LM,
    3. Ager JW,
    4. Sokol RJ.
    Pregnancy outcomes before and after a diagnosis of systemic lupus erythematosus. Am J Obstet Gynecol 2005;193:1444-55.
    OpenUrlCrossRefPubMed
  32. 32.↵
    1. Park C,
    2. Kang MY,
    3. Kim D,
    4. Park J,
    5. Eom H,
    6. Kim EA.
    Prevalence of abortion and adverse pregnancy outcomes among working women in Korea: a cross-sectional study. PloS One 2017;12:e0182341.
    OpenUrl
  33. 33.↵
    1. Bundhun PK,
    2. Soogund MZS,
    3. Huang F.
    Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: a meta-analysis of studies published between years 2001-2016. J Autoimmun 2017;79:17-27.
    OpenUrlCrossRef
  34. 34.↵
    1. Deguchi M,
    2. Maesawa Y,
    3. Kubota S,
    4. Morizane M,
    5. Tanimura K,
    6. Ebina Y, et al.
    Factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus. J Reprod Immunol 2018;125:39-44.
    OpenUrl
  35. 35.↵
    1. Clowse ME,
    2. Magder LS,
    3. Witter F,
    4. Petri M.
    Early risk factors for pregnancy loss in lupus. Obstet Gynecol 2006;107:293-9.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Tincani A,
    2. Bompane D,
    3. Danieli E,
    4. Doria A.
    Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome). Lupus 2006;15:156-60.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Mecacci F,
    2. Bianchi B,
    3. Pieralli A,
    4. Mangani B,
    5. Moretti A,
    6. Cioni R, et al.
    Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies. Rheumatology 2009;48:246-9.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Park MC,
    2. Park YB,
    3. Jung S,
    4. Chung IH,
    5. Choi KH,
    6. Lee SK.
    Risk of ovarian failure and pregnancy outcome in patients with lupus nephritis treated with intravenous cyclophosphamide pulse therapy. Lupus 2004;13:569-74.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Sammaritano LR,
    2. Bermas BL,
    3. Chakravarty EE,
    4. Chambers C,
    5. Clowse ME,
    6. Lockshin MD, et al.
    2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Rheumatol 2020;72:529-56.
    OpenUrlPubMed
  40. 40.↵
    1. Gatto M,
    2. Zen M,
    3. Iaccarino L,
    4. Doria A.
    New therapeutic strategies in systemic lupus erythematosus management. Nat Rev Rheumatol 2019;15:30-48.
    OpenUrlPubMed
  41. 41.↵
    1. Kwok LW,
    2. Tam LS,
    3. Zhu T,
    4. Leung YY,
    5. Li E.
    Predictors of maternal and fetal outcomes in pregnancies of patients with systemic lupus erythematosus. Lupus 2011;20:829-36.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Petri M,
    2. Magder LS.
    Comparison of remission and lupus low disease activity state in damage prevention in a united states systemic lupus erythematosus cohort. Arthritis Rheumatol 2018;70:1790-5.
    OpenUrl
  43. 43.↵
    1. Ruiz-Irastorza G,
    2. Danza A,
    3. Khamashta M.
    Glucocorticoid use and abuse in SLE. Rheumatology 2012;51:1145-53.
    OpenUrlCrossRefPubMed
  44. 44.↵
    1. Shirley E,
    2. Chakravarty EF.
    Treatment of systemic lupus erythematosus (SLE) in pregnancy. Curr Treat Options Rheum 2018;4:110-8.
    OpenUrl
  45. 45.↵
    1. Apostolopoulos D,
    2. Kandane-Rathnayake R,
    3. Louthrenoo W,
    4. Luo SF,
    5. Wu Y-J,
    6. Lateef A, et al.
    Factors associated with damage accrual in patients with systemic lupus erythematosus with no clinical or serological disease activity: a multicentre cohort study. Lancet Rheumatol 2020;2:e24-e30.
    OpenUrl
  46. 46.↵
    1. Knight CL,
    2. Nelson-Piercy C.
    Management of systemic lupus erythematosus during pregnancy: challenges and solutions. Open Access Rheumatol 2017;9:37-53.
    OpenUrl
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1 May 2021
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Lupus Low Disease Activity State Achievement Is Important for Reducing Adverse Outcomes in Pregnant Patients With Systemic Lupus Erythematosus
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Jeong I. Yang, Dong W. Kwak, Chang-Hee Suh
The Journal of Rheumatology May 2021, 48 (5) 707-716; DOI: 10.3899/jrheum.200802

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Lupus Low Disease Activity State Achievement Is Important for Reducing Adverse Outcomes in Pregnant Patients With Systemic Lupus Erythematosus
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Jeong I. Yang, Dong W. Kwak, Chang-Hee Suh
The Journal of Rheumatology May 2021, 48 (5) 707-716; DOI: 10.3899/jrheum.200802
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Keywords

CORTICOSTEROID
fetal complications
lupus low disease activity state
maternal complications
PREGNANCY
SYSTEMIC LUPUS ERYTHEMATOSUS

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