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Research ArticleImages in Rheumatology

Black-blood Magnetic Resonance Imaging in Giant Cell Arteritis

Jan Vynckier, Jelle Demeestere and Julie Lambert
The Journal of Rheumatology February 2021, 48 (2) 301-302; DOI: https://doi.org/10.3899/jrheum.190286
Jan Vynckier
Jan Vynckier, MD, Stroke Research Physician, Department of Neurology, Inselspital, Bern, Switzerland;
Roles: Stroke Research Physician
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  • For correspondence: janluc.vynckier@insel.ch
Jelle Demeestere
Jelle Demeestere, MD, Consultant Neurologist; Julie Lambert, MD, Consultant Neuroradiologist, Department of Neurology and Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
Roles: Consultant Neurologist
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Julie Lambert
Jelle Demeestere, MD, Consultant Neurologist; Julie Lambert, MD, Consultant Neuroradiologist, Department of Neurology and Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
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Giant cell arteritis (GCA) affects large extracranial supraaortic arteries. Ischemic stroke is a presenting feature in up to 10% and carries a mortality rate of 75%1.

A 72-year-old woman was admitted with acute dizziness and jaw claudication. Clinical examination showed swollen temporal arteries, dysarthria, ataxia of the lower limbs, and left hemianopia. Erythrocyte sedimentation rate was elevated (48 mm/h). Brain magnetic resonance imaging (MRI) showed infarction of the right occipital lobe and the cerebellar hemispheres. High-resolution black-blood contrast-enhanced T1-weighted MRI showed vessel wall enhancement of the extradural vertebral and carotid arteries as well as the temporal and occipital arteries (Figure 1). A left temporal artery biopsy was performed, confirming giant cell formation and arterial wall inflammation with lymphocytic infiltrate (Figure 2). Despite maximal therapy with dual antiplatelet therapy and high-dose methylprednisolone, the patient died after having multiple strokes, 3 weeks after admission.

Figure 1.
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Figure 1.

Axial black-blood MRI of the brain and extracranial arteries. There is contrast enhancement of the vessel wall of both temporal arteries (arrows). MRI: magnetic resonance imaging.

Figure 2.
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Figure 2.

Histologic specimen with hematoxylin and eosin stain demonstrating a shrunken arterial lumen (A) with perivascular lymphocytic infiltrates (L) and typical giant cell formation (arrows).

The diagnosis of GCA remains challenging and often requires additional tests such as 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and biopsy. Black-blood MRI uses a prepulse for suppression of intraluminal gadolinium to create a high-contrast image of the blood vessel wall. This technique has been used for detection of vessel wall abnormalities, such as cervical dissection2 or central nervous system vasculitis and has been shown to detect arteritic anterior optic neuropathy in patients with GCA3. We report its use for diagnosis of GCA. Further studies are needed to investigate concordance between black-blood MRI and clinical symptoms, pathology, and FDG-PET.

  • Copyright © 2021 by the Journal of Rheumatology

REFERENCES

  1. 1.↵
    1. Samson M,
    2. Jacquin A,
    3. Audia S,
    4. Daubail B,
    5. Devilliers H,
    6. Petrella T, et al.
    Stroke associated with giant cell arteritis: a population-based study. J Neurol Neurosurg Psychiatry 2015;86:216-21.
    OpenUrlAbstract/FREE Full Text
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    1. Schwarz F,
    2. Strobl FF,
    3. Cyran CC,
    4. Helck AD,
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    Reproducibility and differentiation of cervical arteriopathies using in vivo high-resolution black-blood MRI at 3 T. Neuroradiology 2016;58:569-76.
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    Three-dimensional high-resolution black-blood magnetic resonance imaging for detection of arteritic anterior ischemic optic neuropathy in patients with giant cell arteritis. Invest Radiol 2018;53:698-704.
    OpenUrlCrossRefPubMed
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Black-blood Magnetic Resonance Imaging in Giant Cell Arteritis
Jan Vynckier, Jelle Demeestere, Julie Lambert
The Journal of Rheumatology Feb 2021, 48 (2) 301-302; DOI: 10.3899/jrheum.190286

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Black-blood Magnetic Resonance Imaging in Giant Cell Arteritis
Jan Vynckier, Jelle Demeestere, Julie Lambert
The Journal of Rheumatology Feb 2021, 48 (2) 301-302; DOI: 10.3899/jrheum.190286
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