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Research ArticleGout

Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout

William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera and Angelo L. Gaffo
The Journal of Rheumatology February 2021, 48 (2) 293-298; DOI: https://doi.org/10.3899/jrheum.191242
William Taylor
1W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand;
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Nicola Dalbeth
2N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand;
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Kenneth G. Saag
3K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA;
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Jasvinder A. Singh
4J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA;
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Elizabeth J. Rahn
3K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA;
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Amy S. Mudano
3K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA;
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Yi-Hsing Chen
5Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan;
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Ching-Tsai Lin
5Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan;
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Paul Tan
2N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand;
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Worawit Louthreno
6W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand;
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Janitzia Vazquez-Mellado
7J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico;
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Hansel Hernández-Llinas
7J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico;
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Tuhina Neogi
8T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA;
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  • ORCID record for Tuhina Neogi
Ana B. Vargas-Santos
8T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA;
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  • ORCID record for Ana B. Vargas-Santos
Geraldo Castelar-Pinheiro
9G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;
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Rodrigo B. Chaves-Amorim
9G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;
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Tillman Uhlig
10T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway;
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Hilde B. Hammer
10T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway;
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Maxim Eliseev
11M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia;
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Fernando Perez-Ruiz
12F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain;
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Lorenzo Cavagna
13L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy;
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Geraldine M. McCarthy
14G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland;
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Lisa K. Stamp
15L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand;
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Martijin Gerritsen
16M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands;
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Viktoria Fana
17V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark;
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Francisca Sivera
18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain.
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Angelo L. Gaffo
4J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA;
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  • For correspondence: agaffo@uabmc.edu
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REFERENCES

  1. 1.↵
    1. Neogi T.
    Gout. Ann Intern Med 2016;165:ITC1-16.
    OpenUrl
  2. 2.↵
    1. Hui M,
    2. Carr A,
    3. Cameron S,
    4. Davenport G,
    5. Doherty M,
    6. Forrester H, et al.
    The British Society for Rheumatology guideline for the management of gout. Rheumatology 2017;56:e1-20.
    OpenUrl
  3. 3.↵
    1. Khanna D,
    2. Fitzgerald JD,
    3. Khanna PP,
    4. Bae S,
    5. Singh MK,
    6. Neogi T, et al.
    2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res 2012;64:1431-46.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Richette P,
    2. Doherty M,
    3. Pascual E,
    4. Barskova V,
    5. Becce F,
    6. Castañeda-Sanabria J, et al.
    2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis 2017;76:29-42.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Taylor WJ,
    2. Brown M,
    3. Aati O,
    4. Weatherall M,
    5. Dalbeth N.
    Do patient preferences for core outcome domains for chronic gout studies support the validity of composite response criteria? Arthritis Care Res 2013;65:1259-64.
    OpenUrl
  6. 6.↵
    1. Taylor WJ,
    2. Schumacher HR Jr,
    3. Baraf HS,
    4. Chapman P,
    5. Stamp L,
    6. Doherty M, et al.
    A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout. Ann Rheum Dis 2008;67:888-91.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. de Lautour H,
    2. Taylor WJ,
    3. Adebajo A,
    4. Alten R,
    5. Burgos-Vargas R,
    6. Chapman P, et al.
    Development of preliminary remission criteria for gout using Delphi and 1000Minds consensus exercises. Arthritis Care Res 2016;68:667-72.
    OpenUrl
  8. 8.↵
    1. Wells G,
    2. Boers M,
    3. Tugwell P,
    4. Group MW.
    Low disease activity state in rheumatoid arthritis: concepts and derivation of minimal disease activity. Clin Exp Rheumatol 2006;24:S52-9.
    OpenUrlPubMed
  9. 9.↵
    1. Tubach F,
    2. Wells GA,
    3. Ravaud P,
    4. Dougados M.
    Minimal clinically important difference, low disease activity state, and patient acceptable symptom state: methodological issues. J Rheumatol 2005;32:2025-9.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Gaffo AL,
    2. Dalbeth N,
    3. Saag KG,
    4. Singh J,
    5. Rahn EJ,
    6. Mudano AS, et al.
    Validation of a definition of flare in patients with established gout. Arthritis Rheumatol 2018;70:462-7.
    OpenUrl
  11. 11.↵
    1. Tubach F,
    2. Ravaud P,
    3. Baron G,
    4. Falissard B,
    5. Logeart I,
    6. Bellamy N, et al.
    Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state. Ann Rheum Dis 2005;64:34-7.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Luo J,
    2. Xiong C.
    Diagtest3grp: an R package for analyzing diagnostic tests with three ordinal groups. J Stat Softw 2012;51:1-24.
    OpenUrlPubMed
  13. 13.↵
    1. He X,
    2. Frey EC.
    The meaning and use of the volume under a three-class ROC surface (VUS). IEEE Trans Med Imaging 2008;27:577-88.
    OpenUrlPubMed
  14. 14.↵
    1. Lindsay K,
    2. Gow P,
    3. Vanderpyl J,
    4. Logo P,
    5. Dalbeth N.
    The experience and impact of living with gout: a study of men with chronic gout using a qualitative grounded theory approach. J Clin Rheumatol 2011;17:1-6.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Diaz_Torne C,
    2. Pou MA,
    3. Castellvi I,
    4. Corominas H,
    5. Taylor WJ.
    Concerns of patients with gout are incompletely captured by OMERACT-endorsed domains of measurement for chronic gout studies. J Clin Rheumatol 2014;20:138-40.
    OpenUrl
  16. 16.↵
    1. Tatlock S,
    2. Rüdell K,
    3. Panter C,
    4. Arbuckle R,
    5. Harrold LR,
    6. Taylor WJ, et al.
    What outcomes are important for gout patients? In-depth qualitative research into the gout patient experience to determine optimal endpoints for evaluating therapeutic interventions. Patient 2017;10:65-79.
    OpenUrl
  17. 17.↵
    1. De Meulemeester M,
    2. Jansen T,
    3. Petersen G,
    4. Perez-Ruiz F.
    European patient voice in gout survey - subjective satisfaction in gout patients versus objective suboptimal gout care [abstract]. Ann Rheum Dis 2019;78:A153.
    OpenUrl
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Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout
William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera, Angelo L. Gaffo
The Journal of Rheumatology Feb 2021, 48 (2) 293-298; DOI: 10.3899/jrheum.191242

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Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout
William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera, Angelo L. Gaffo
The Journal of Rheumatology Feb 2021, 48 (2) 293-298; DOI: 10.3899/jrheum.191242
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Keywords

DISEASE ACTIVITY
GOUT
REMISSION

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Keywords

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  • gout
  • remission

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