Incidence and Prevalence of Juvenile Systemic Lupus Erythematosus in Korea: Data From the 2017 National Health Claims Database

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Figure 1.
Change point of incidence and prevalence in female patients with JSLE. According to the change-point analysis, we found that the incidence (left) and prevalence (right) of female patients increased rapidly at the ages of 14 and 15 years, respectively.

Table 1.

Prevalence of JSLE.

Age, yrs	N	Overall		N	Male		N	Female
Age, yrs	N	Population	Rate (95% CI)	N	Population	Rate (95% CI)	N	Population	Rate (95% CI)
Overall	447	6,455,854	6.92 (6.90–6.94)	93	3,342,952	2.78 (2.76–2.80)	354	3,112,902	11.37 (11.34–11.41)
5	1	482,297	0.21 (0.20–0.22)	1	247,529	0.40 (0.38–0.43)	0	234,769	-
6	3	474,368	0.63 (0.61–0.66)	1	244,012	0.41 (0.38–0.44)	2	230,356	0.87 (0.86–0.91)
7	5	460,372	1.09 (1.06–1.12)	2	237,194	0.84 (0.81–0.88)	3	223,178	1.34 (1.30–1.39)
8	7	457,979	1.53 (1.49–1.56)	2	235,772	0.85 (0.81–0.89)	5	222,207	2.25 (2.19–2.31)
9	11	481,854	2.28 (2.24–2.33)	4	247,880	1.61 (1.56–1.66)	7	233,975	2.99 (2.92–3.06)
10	12	472,317	2.54 (2.50–2.59)	4	243,522	1.64 (1.59–1.69)	8	228,795	3.5 (3.42–3.57)
11	20	442,524	4.52 (4.46–4.58)	4	229,015	1.75 (1.69–1.80)	16	213,509	7.49 (7.38–7.61)
12	26	454,656	5.72 (5.65–5.79)	7	235,616	2.97 (2.90–3.04)	19	219,040	8.67 (8.56–8.79)
13	32	483,215	6.62 (6.55–6.69)	7	250,765	2.79 (2.73–2.86)	25	232,450	10.76 (10.63–10.88)
14	43	493,510	8.71 (8.63–8.79)	12	257,027	4.67 (4.59–4.75)	31	236,483	13.11 (12.97–13.25)
15	50	526,372	9.5 (9.42–9.58)	10	274,449	3.64 (3.57–3.71)	40	251,923	15.88 (15.74–16.02)
16	95	598,289	15.88 (15.79–15.97)	14	312,162	4.48 (4.41–4.56)	81	286,127	28.31 (28.14–28.47)
17	142	628,104	22.61 (22.50–22.71)	25	328,012	7.62 (7.53–7.71)	117	300,092	38.99 (38.81–38.99)

Table 2.

Incidence of JSLE.

Age, yrs	Overall			Male			Female
	Cases, n	Population	Rate (95% CI)	Cases, n	Population	Rate (95% CI)	Cases, n	Population	Rate (95% CI)
Overall	178	6,455,854	2.76 (2.75–2.77)	45	3,342,952	1.35 (1.33–1.36)	133	3,112,902	4.27 (4.25–4.30)
5	1	482,297	0.21 (0.19–0.22)	1	247,529	0.40 (0.38–0.43)	0	234,769	–
6	2	474,367	0.42 (0.40–0.44)	1	244,011	0.41 (0.38–0.44)	1	230,356	0.43 (0.41–0.46)
7	4	460,369	0.87 (0.84–0.90)	2	237,193	0.84 (0.81–0.88)	2	223,176	0.90 (0.86–0.94)
8	4	457,974	0.87 (0.85–0.90)	2	235,770	0.85 (0.81–0.89)	2	222,204	0.90 (0.86–0.94)
9	5	481,847	1.04 (1.01–1.07)	1	247,878	0.40 (0.38–0.43)	4	233,970	1.71 (1.66–1.76)
10	6	472,306	1.27 (1.24–1.30)	2	243,518	0.82 (0.79–0.86)	4	228,788	1.75 (1.70–1.80)
11	11	442,512	2.49 (2.44–2.53)	3	229,011	1.31 (1.26–1.36)	8	213,501	3.75 (3.67–3.83)
12	10	454,636	2.20 (2.16–2.24)	2	235,612	0.85 (0.81–0.89)	8	219,024	3.65 (3.57–3.73)
13	14	483,189	2.90 (2.85–2.94)	2	250,758	0.80 (0.76–0.83)	12	232,431	5.16 (5.07–5.25)
14	21	493,478	4.26 (4.20–4.31)	7	257,020	2.72 (2.66–2.79)	14	236,458	5.92 (5.83–6.02)
15	24	526,329	4.56 (4.50–4.62)	4	274,437	1.46 (1.41–1.50)	20	251,892	7.94 (7.83–8.05)
16	37	598,239	6.18 (6.12–6.25)	9	312,152	2.88 (2.82–2.94)	28	286,087	9.79 (9.68–9.90)
17	39	628,009	6.21 (6.15–6.27)	9	327,998	2.74 (2.69–2.80)	30	300,011	10.0 (9.89–10.11)