Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticleSjögren Syndrome

Mixed Airway and Pulmonary Parenchymal Disease in Patients With Primary Sjögren Syndrome: A 6-year Follow-up

Anna Matilda Nilsson, H. Laura Aaltonen, Peter Olsson, Hans Lennart Persson, Roger Hesselstrand, Elke Theander, Per Wollmer and Thomas Mandl
The Journal of Rheumatology February 2021, 48 (2) 232-240; DOI: https://doi.org/10.3899/jrheum.200247
Anna Matilda Nilsson
1A.M. Nilsson, MD, PhD, Department of Clinical Sciences Malmö, Lund University, Malmö, and Department of Rheumatology, Linköping University Hospital, Linköping;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anna Matilda Nilsson
  • For correspondence: anna1.nilsson@med.lu.se
H. Laura Aaltonen
2H.L. Aaltonen, MD, PhD, P. Wollmer, MD, PhD, Department of Translational Medicine, Lund University;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Olsson
3P. Olsson, MD, PhD, Department of Clinical Sciences Malmö, Lund University, Malmö;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Peter Olsson
Hans Lennart Persson
4H.L. Persson, MD, PhD, Department of Respiratory Medicine in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hans Lennart Persson
Roger Hesselstrand
5R. Hesselstrand, MD, PhD, Department of Clinical Sciences Lund, Lund University, Lund;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elke Theander
6E. Theander, MD, PhD, Department of Clinical Sciences Malmö, Lund University, and Malmö Jansen Cilag, Solna;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elke Theander
Per Wollmer
2H.L. Aaltonen, MD, PhD, P. Wollmer, MD, PhD, Department of Translational Medicine, Lund University;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Mandl
7T Mandl, MD, PhD, Department of Clinical Sciences Malmö, Lund University, Malmö, and Novartis, Kista, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Thomas Mandl
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective. To assess pulmonary function and chronic obstructive pulmonary disease (COPD) development over time in patients with primary Sjögren syndrome (pSS), as well as the association between pulmonary function, radiographic findings, respiratory symptoms, and clinical features of pSS, taking cigarette consumption into account.

Methods. Forty patients with pSS (mean age 66 yrs; range 42–81 yrs; 39 women), previously participating in a cross-sectional study on pulmonary involvement in pSS, were reassessed by pulmonary function tests after a mean follow-up time of 6 years. At follow-up, patients were also assessed by high-resolution computed tomography of the chest, as well as for pSS disease activity, respiratory symptoms, and cigarette consumption.

Results. Patients with pSS showed significantly decreased percentages of predicted total lung capacity (TLC), residual volume (RV), RV/TLC ratio, and diffusing capacity of the lungs for carbon monoxide, as well as an increase in predicted forced expiratory volume in 1 second/vital capacity (FEV1/VC) ratio from baseline to follow-up. The proportion of COPD in patients with pSS did not change significantly from baseline to follow-up (38% vs 40%, respectively). Radiographic signs of bronchial involvement and interstitial lung disease were each found in 38% of the patients.

Conclusion. Both airway and pulmonary parenchymal disease were commonly found in patients with pSS, with a coexistence of both an obstructive and restrictive pulmonary function pattern, where the latter tended to deteriorate over time. COPD was a common finding. Airway and pulmonary involvement may be underdiagnosed in pSS, which is why special attention to clinical assessment of pulmonary involvement in patients with pSS is mandated.

Key Indexing Terms:
  • diagnostic imaging
  • radiography
  • respiratory diseases
  • Sjögren syndrome
  • Accepted for publication May 6, 2020.
  • Copyright © 2021 by the Journal of Rheumatology
View Full Text

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 48, Issue 2
1 Feb 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Mixed Airway and Pulmonary Parenchymal Disease in Patients With Primary Sjögren Syndrome: A 6-year Follow-up
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Mixed Airway and Pulmonary Parenchymal Disease in Patients With Primary Sjögren Syndrome: A 6-year Follow-up
Anna Matilda Nilsson, H. Laura Aaltonen, Peter Olsson, Hans Lennart Persson, Roger Hesselstrand, Elke Theander, Per Wollmer, Thomas Mandl
The Journal of Rheumatology Feb 2021, 48 (2) 232-240; DOI: 10.3899/jrheum.200247

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Mixed Airway and Pulmonary Parenchymal Disease in Patients With Primary Sjögren Syndrome: A 6-year Follow-up
Anna Matilda Nilsson, H. Laura Aaltonen, Peter Olsson, Hans Lennart Persson, Roger Hesselstrand, Elke Theander, Per Wollmer, Thomas Mandl
The Journal of Rheumatology Feb 2021, 48 (2) 232-240; DOI: 10.3899/jrheum.200247
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters

Keywords

DIAGNOSTIC IMAGING
RADIOGRAPHY
respiratory diseases
SJÖGREN SYNDROME

Related Articles

Cited By...

More in this TOC Section

  • Increased Prevalence of Moderate to Severe Mitral and Aortic Valve Dysfunction in Systemic Sclerosis: A Case-control Study
  • Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health-related Quality of Life in Sjögren Syndrome?
Show more Sjögren Syndrome

Similar Articles

Keywords

  • diagnostic imaging
  • radiography
  • respiratory diseases
  • Sjögren syndrome

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire