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Research ArticleOsteoarthritis

Association of Patients’ Familiarity and Perceptions of Efficacy and Risks With the Use of Opioid Medications in the Management of Osteoarthritis

Ernest R. Vina, Cristian Quinones, Leslie R.M. Hausmann, Said A. Ibrahim and C. Kent Kwoh
The Journal of Rheumatology December 2021, 48 (12) 1863-1870; DOI: https://doi.org/10.3899/jrheum.201133
Ernest R. Vina
1E.R. Vina, MD, MS, Associate Professor of Medicine, C.K. Kwoh, MD, Professor of Medicine, Division of Rheumatology, University of Arizona School of Medicine, Tucson, Arizona;
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  • For correspondence: evina@email.arizona.edu
Cristian Quinones
2C.Q. Quinones, BS, University of Arizona Arthritis Center, Tucson, Arizona;
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Leslie R.M. Hausmann
3L.R. Hausmann, PhD, Core Investigator, Veterans Affairs Pittsburgh Healthcare System, and Associate Professor of Medicine, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
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Said A. Ibrahim
4S. Ibrahim, Professor, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, New York, USA.
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C. Kent Kwoh
1E.R. Vina, MD, MS, Associate Professor of Medicine, C.K. Kwoh, MD, Professor of Medicine, Division of Rheumatology, University of Arizona School of Medicine, Tucson, Arizona;
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Abstract

Objective While opioids are known to cause unintended adverse effects, they are being utilized by a number of patients with osteoarthritis (OA). The aim of this study was to evaluate the association of patient familiarity and perceptions regarding efficacy and risks with opioid medication use for OA.

Methods A total of 362 adults with knee and/or hip OA were surveyed in this cross-sectional study. Patients’ familiarity with and perceptions of benefits/risks of opioid medications were measured to evaluate potential associations with the utilization of opioid medications for OA within the last 6 months. Logistic regression models were adjusted for sociodemographic and clinical variables.

Results In this sample, 28.7% (100/349) reported use of an opioid medication for OA-related symptoms in the last 6 months. Those who were on an opioid medication, compared to those who were not, were younger (mean age 62.5 vs 64.8 yrs), were more likely to have a high school education or lower (48.0% vs 35.3%), and had higher mean depression (Patient Health Questionnaire [PHQ]-8 7.2 vs 4.9) and OA-related pain (Western Ontario and McMaster Universities Arthritis Index [WOMAC] 54.8 vs 46.8) scores. After adjustment for sociodemographic and clinical variables, the following were associated with opioid medication use: higher perception of medication benefit (OR 1.68, 95% CI 1.18–2.41), lower perception of medication risk (OR 0.67, 95% CI 0.51–0.88), and having family or friends who received the medication for OA (OR 3.88, 95% CI 1.88–8.02).

Conclusion Among adults with knee/hip OA, opioid use was associated with being familiar with the treatment, as well as believing that the medication was beneficial and low-risk.

Key Indexing Terms:
  • familiarity
  • opioids
  • osteoarthritis
  • perceptions
  • treatment utilization
  • Accepted for publication January 8, 2021.
  • Copyright © 2021 by the Journal of Rheumatology
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The Journal of Rheumatology
Vol. 48, Issue 12
1 Dec 2021
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Association of Patients’ Familiarity and Perceptions of Efficacy and Risks With the Use of Opioid Medications in the Management of Osteoarthritis
Ernest R. Vina, Cristian Quinones, Leslie R.M. Hausmann, Said A. Ibrahim, C. Kent Kwoh
The Journal of Rheumatology Dec 2021, 48 (12) 1863-1870; DOI: 10.3899/jrheum.201133

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Association of Patients’ Familiarity and Perceptions of Efficacy and Risks With the Use of Opioid Medications in the Management of Osteoarthritis
Ernest R. Vina, Cristian Quinones, Leslie R.M. Hausmann, Said A. Ibrahim, C. Kent Kwoh
The Journal of Rheumatology Dec 2021, 48 (12) 1863-1870; DOI: 10.3899/jrheum.201133
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Keywords

familiarity
opioids
OSTEOARTHRITIS
PERCEPTIONS
treatment utilization

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