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Research ArticlePediatric Rheumatology

Correlation of a Modified Disease Activity Score (DAS) with the Validated Original DAS in Patients with Juvenile Dermatomyositis

Hayyah Clairman, Saunya Dover, Kristi Whitney, Jo-Anne Marcuz, Audrey Bell-Peter and Brian M. Feldman
The Journal of Rheumatology January 2021, 48 (1) 101-104; DOI: https://doi.org/10.3899/jrheum.191255
Hayyah Clairman
1H. Clairman, MSc, S. Dover, MSc, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children;
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  • ORCID record for Hayyah Clairman
Saunya Dover
1H. Clairman, MSc, S. Dover, MSc, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children;
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Kristi Whitney
1H. Clairman, MSc, S. Dover, MSc, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children;
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Jo-Anne Marcuz
1H. Clairman, MSc, S. Dover, MSc, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children;
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Audrey Bell-Peter
2K. Whitney, PT, MSc, J.A. Marcuz, PT, Division of Rheumatology, Department of Pediatrics, and Department of Rehabilitation, The Hospital for Sick Children;
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Brian M. Feldman
2K. Whitney, PT, MSc, J.A. Marcuz, PT, Division of Rheumatology, Department of Pediatrics, and Department of Rehabilitation, The Hospital for Sick Children;
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  • For correspondence: brian.feldman@sickkids.ca
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Abstract

Objective. Juvenile dermatomyositis (JDM) is a rare disease in children that is treatable, but patients may suffer from long-term effects. Clinical trials are needed to find better treatments for affected patients. Among validated tools for evaluating disease activity clinically is the Disease Activity Score (DAS), but it is not routinely collected in all clinics. We developed a modified DAS (DASmod), which can be scored using data routinely collected by our clinical staff and has been used in previous studies. The aim of this study was to determine if our DASmod correlates with the validated DAS in patients with JDM.

Methods. In this study, we used DASmod (scored 0–12) and DAS (scored 0–20) scores for patients with JDM in our clinic. We analyzed the correlation between the DASmod and the validated DAS.

Results. For 51 patients seen in our JDM clinic, the median (IQR) DASmod score was 2.0 (0–4.0) and the DAS score was 3.0 (0–5.5). Scores on the 2 tools were highly positively correlated (r = 0.94, P < 0.001, 95% CI 0.89–0.96). The linear regression was significant [R2 = 0.88, F (1, 49) = 357.60, P < 0.001] and in this dataset, the tools can be used interchangeably with the regression equation: DAS score = –0.26 + 1.5*DASmod.

Conclusion. If the regression equation from this dataset is successfully tested against future datasets, then further research collaborations between centers that collect different data related to disease activity in children with JDM will be facilitated.

Key Indexing Terms:
  • dermatomyositis
  • physical therapy
  • treatment outcome
  • Accepted for publication March 6, 2020.
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1 Jan 2021
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Correlation of a Modified Disease Activity Score (DAS) with the Validated Original DAS in Patients with Juvenile Dermatomyositis
Hayyah Clairman, Saunya Dover, Kristi Whitney, Jo-Anne Marcuz, Audrey Bell-Peter, Brian M. Feldman
The Journal of Rheumatology Jan 2021, 48 (1) 101-104; DOI: 10.3899/jrheum.191255

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Correlation of a Modified Disease Activity Score (DAS) with the Validated Original DAS in Patients with Juvenile Dermatomyositis
Hayyah Clairman, Saunya Dover, Kristi Whitney, Jo-Anne Marcuz, Audrey Bell-Peter, Brian M. Feldman
The Journal of Rheumatology Jan 2021, 48 (1) 101-104; DOI: 10.3899/jrheum.191255
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Keywords

DERMATOMYOSITIS
PHYSICAL THERAPY
TREATMENT OUTCOME

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Keywords

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  • physical therapy
  • treatment outcome

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