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Research ArticleSpondyloarthritis

Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort

Sytse F. Oudkerk, Firdaus A.A. Mohamed Hoesein, F. Cumhur Öner, Jorrit-Jan Verlaan, Pim A. de Jong, Jonneke S. Kuperus, Michael Cho, Merry-Lynn McDonald, David A. Lynch, Edwin K. Silverman, James D. Crapo, Barry J. Make, Katherine E. Lowe and Elizabeth A. Regan
The Journal of Rheumatology April 2020, 47 (4) 531-538; DOI: https://doi.org/10.3899/jrheum.181357
Sytse F. Oudkerk
From the University Medical Center Utrecht and Utrecht University, Department of Radiology and Nuclear Medicine, and Department of Orthopedics, Utrecht, the Netherlands; National Jewish Health, Department of Radiology, and divisions of Oncology, Pulmonary, Critical Care, Sleep Medicine, and Rheumatology, Denver, Colorado; Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts; Division of Pulmonary, Allergy, and Critical Care Medicine, and Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA; London School of Hygiene and Tropical Medicine, London, UK.
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Firdaus A.A. Mohamed Hoesein
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F. Cumhur Öner
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Jorrit-Jan Verlaan
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Pim A. de Jong
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  • For correspondence: p.dejong-8@umcutrecht.nl
Jonneke S. Kuperus
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  • ORCID record for Jonneke S. Kuperus
Michael Cho
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Merry-Lynn McDonald
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David A. Lynch
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Edwin K. Silverman
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James D. Crapo
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Barry J. Make
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Katherine E. Lowe
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Elizabeth A. Regan
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Abstract

Objective. Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by bony proliferation at sites of tendinous and ligamentous insertions in the spine. Spinal mobility is reduced in DISH and may affect movement in the thorax, potentially leading to restrictive pulmonary function. This study investigated whether DISH is associated with restrictive spirometric pattern (RSP) in former and current smokers.

Methods. Participants (n = 1784) with complete postbronchodilator spirometry who did not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) at time of enrollment in the COPDGene study were included in this study. Subjects were classified as RSP if they had forced expiratory volume in 1 s(FEV1) to forced vital capacity (FVC) ratio > 0.7 with an FVC < 80%. Computed tomography (CT) scans were scored for the presence of DISH in accordance with the Resnick criteria. Chest CT measures of interstitial and alveolar lung disease, clinical symptoms, health surveys, and 6-min walking distance were recorded. Uni- and multivariable analyses were performed to test the association of DISH with RSP.

Results. DISH was present in 236 subjects (13.2%). RSP was twice as common in participants with DISH (n = 90/236, 38.1%) compared to those without DISH (n = 301/1548, 19.4%; p < 0.001). In multivariable analysis, DISH was significantly associated with RSP (OR 1.78; 95% CI 1.22–2.60; p = 0.003) after adjusting for potential confounders. The RSP group with and without DISH had significantly worse spirometry, dyspnea, St. George’s Respiratory Questionnaire score, BODE index (Body mass index, airflow Obstruction, Dyspnea and Exercise capacity), and Medical Outcomes Study Short Form-36 questionnaire score.

Conclusion. In heavy smokers with an FEV1/FVC ratio > 0.70, DISH is associated with RSP after adjustment for intrinsic and extrinsic causes of restrictive lung function. (Clinical trial registration number: NCT00608764.)

Key Indexing Terms:
  • DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS
  • COMPUTED TOMOGRAPHY
  • SPIROMETRY
  • LUNG FUNCTION

Footnotes

  • This work was supported by the US National Heart, Lung, and Blood Institute (award number U01 HL089897, award number U01 HL089856). Dr. E.K. Silverman has received grant and travel support from GlaxoSmithKline.

  • Accepted for publication April 6, 2019.
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The Journal of Rheumatology
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1 Apr 2020
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Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort
Sytse F. Oudkerk, Firdaus A.A. Mohamed Hoesein, F. Cumhur Öner, Jorrit-Jan Verlaan, Pim A. de Jong, Jonneke S. Kuperus, Michael Cho, Merry-Lynn McDonald, David A. Lynch, Edwin K. Silverman, James D. Crapo, Barry J. Make, Katherine E. Lowe, Elizabeth A. Regan
The Journal of Rheumatology Apr 2020, 47 (4) 531-538; DOI: 10.3899/jrheum.181357

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Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort
Sytse F. Oudkerk, Firdaus A.A. Mohamed Hoesein, F. Cumhur Öner, Jorrit-Jan Verlaan, Pim A. de Jong, Jonneke S. Kuperus, Michael Cho, Merry-Lynn McDonald, David A. Lynch, Edwin K. Silverman, James D. Crapo, Barry J. Make, Katherine E. Lowe, Elizabeth A. Regan
The Journal of Rheumatology Apr 2020, 47 (4) 531-538; DOI: 10.3899/jrheum.181357
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Keywords

DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS
COMPUTED TOMOGRAPHY
SPIROMETRY
LUNG FUNCTION

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