Article Figures & Data
Tables
- Table 1.
Classification criteria among subjects with primary Sjögren syndrome with a focus score > 1 (FS > 1), a focus score of zero (FS = 0), and a focus score between zero and 1 (0 < FS < 1). All subjects answered positively at least 1 dry eye question and 1 dry mouth question from the AECG criteria.
FS ≥ 1, n = 167 FS = 0, n = 51 0 < FS < 1, n = 11 p ≥ 1 vs 0 ≥ 1 vs < 1 Anti-La/SSB (%) 98 (59) 10 (20) 4 (36) < 0.0001 0.145 WUSF (%) 103* (63) 36 (71) 6 (55) 0.309 0.160 Schirmer test (%) 85** (52) 18† (36) 6 (55) 0.05 0.140 Lissamine green (%) 115‡ (72) 25 (50) 8 (73) 0.0032 0.152 - Table 2.
Manifestations from the European Sjögren’s Syndrome Disease Activity Index among subjects with primary Sjögren syndrome with a focus score > 1 (FS > 1), a focus score of zero (FS = 0), and a focus score between zero and 1 (0 < FS < 1).
Manifestation FS ≥ 1, n = 167 FS = 0, n = 51 0 < FS < 1, n = 11 p > 1 vs 0 > 1 vs < 1 Parotid 36 9 0 0.558 0.150 Submandibular 21 9 0 0.349 0.150 Lymphadenopathy 8 4 0 0.179 0.448 Constitutional 50 22 3 0.07 0.174 Peripheral neuropathy 51 14 4 0.690 0.230 Persistent cough 50 17 3 0.62 0.264 Arthralgia 105 42 8 0.0094 0.232 Arthritis* 12 4 1 0.231 0.424 Arthritis** 21 6 0 0.889 0.293 RP** 52 14 2 0.633 0.260 Leukopenia 19 5 1 0.763 0.420 Neutropenia 0 0 0 NA NA Lymphopenia 7 2 1 0.311 0.370 Thrombocytopenia 2 1 0 0.414 0.822 Hyper IgG*** 61 5 3 0.0003 0.114 Hyper IgA 26 7 3 0.759 0.177 Hyper IgM 28 9 1 0.883 0.311 Low C3 0 0 0 NA NA Low C4 7 2 0 0.311 0.674 Other antibodies 51 10 3 0.133 0.253 Hypo IgG 5 2 0 0.307 0.674 ↵* Documented in history and physical examination by physician.
↵** Self-reported on questionnaire.
↵*** 20 g/l used as the demarcation for an elevated value because in the biological domain of the SSDAI, a serum IgG level > 20 g/l is considered positive. The biological domain is considered active if the serum IgG level is above this concentration. SSDAI: Sjögren’s Syndrome Disease Activity Index; RP: Raynaud phenomenon; NA: not applicable.
- Table 3.
Interferon-regulated gene expression categorized by unsupervised hierarchical clustering among subjects with primary Sjögren syndrome, some with a focus score (FS) > 1 on minor salivary gland pathology and some with a focus score of zero.
Interferon-regulated Gene Expression High Intermediate Low Anti-Ro, FS = 0, n = 6 0*† 2 4 Anti-Ro, FS ≥ 1, n = 47 31 15 5
