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Research ArticleSpondyloarthritis

Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort

Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories and Maxime Dougados
The Journal of Rheumatology March 2020, 47 (3) 349-353; DOI: https://doi.org/10.3899/jrheum.181326
Daniel Wendling
From Rheumatology, CHRU de Besançon (University Teaching Hospital); Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB); Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, European League Against Rheumatism (EULAR) Center Of Excellence; INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
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  • For correspondence: dwendling@chu-besancon.fr
Xavier Guillot
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Clément Prati
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Corinne Miceli-Richard
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Anna Molto
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Rik Lories
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  • ORCID record for Rik Lories
Maxime Dougados
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Article Figures & Data

Tables

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    Table 1.

    Factors associated with inflammatory bowel disease (IBD) at baseline (univariable analysis).

    VariablesIBD+ vs IBD−, Prevalent M0
    OR (95% CI) or mean (SD)p
    HLA-B270.47 (0.21–0.98)0.03
    mNY criteria at M02.28 (0.94–5.12)0.05
    Uveitis history3.80 (1.49–8.90)0.003
    Familial history of IBD3.97 (1.11–11.57)0.02
    Psoriasis0.09 (0.02–0.24)< 0.0001
    DMARD use3.74 (1.63–8.19)< 0.001
    Steroid use4.21 (1.83–9.25)< 0.001
    NSAID score at 6 mos30.2 (36.0) vs 45.5 (40.5)0.005
    Sick leave, days33.9 (49.3) vs 32.7 (69.1)0.09
    ESR, mm/h22.6 (26.7) vs 13.3 (14.5)0.04
    Hemoglobin, g/dl15.7 (19.0) vs 16.0 (18.0)0.02
    • M0: Month 0; mNY: modified New York criteria; DMARD: disease-modifying antirheumatic drug; NSAID: nonsteroidal antiinflammatory drug; ESR: erythrocyte sedimentation rate.

    • View popup
    Table 2.

    Factors associated with inflammatory bowel disease (IBD) at the 5-year visit (M60; univariable analysis).

    VariablesIBD+ vs IBD−, Prevalent M60
    OR (95% CI) or mean (SD)p
    DMARD use2.58 (1.35–5.08)0.002
    NSAID score at 6 months17.00 (31.20) vs 19.87 (30.37)0.03
    Sick leave, days20.80 (59.16) vs 11.35 (39.19)0.03
    Anti-TNF useV(yes/no)2.11 (1.06–4.31)0.02
    ASDAS CRP2.28 (0.85) vs 2.02 (0.83)0.03
    BASFI29.04 (20.14) vs 22.08 (21.18)0.02
    SF-36 physical39.26 (9.91) vs 43.59 (9.60)0.004
    SF-36 mental41.2 (11.62) vs 45.2 (11.06)0.013
    HAQ0.75 (0.58) vs 0.50 (0.51)0.004
    ASQoL8.72 (5.65) vs 6.59 (5.37)0.012
    No. tender joints5.84 (9.77) vs 2.37 (5.80)0.009
    • M60: Month 60; DMARD: disease-modifying antirheumatic drug; NSAID: nonsteroidal antiinflammatory drug; anti-TNF: anti-tumor necrosis factor; ASDAS: Ankylosing Spondylitis Disease Activity Score; CRP: C-reactive protein; BASFI: Bath Ankylosing Spondylitis Functional Index; SF-36: Medical Outcomes Study Short Form-36 questionnaire; HAQ: Health Assessment Questionnaire; ASQoL: Ankylosing Spondylitis Quality of Life score.

    • View popup
    Table 3.

    Baseline factors associated with incidence of new cases of inflammatory bowel disease (IBD) between baseline and 5 years (univariable analysis).

    VariablesIBD+ vs IBD−
    OR (95% CI) or mean (SD)p
    mNY criteria at M02.58 (0.88–6.81)0.006
    Familial history of IBD3.97 (0.92–13.02)0.032
    Psoriasis0 (0–0.73)0.013
    SF-36 physical36.75 (8.75) vs 40.34 (9.04)0.047
    • mNY: modified New York criteria; M0: Month 0; SF-36: Medical Outcomes Study Short Form-36 questionnaire.

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1 Mar 2020
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Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort
Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories, Maxime Dougados
The Journal of Rheumatology Mar 2020, 47 (3) 349-353; DOI: 10.3899/jrheum.181326

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Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort
Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories, Maxime Dougados
The Journal of Rheumatology Mar 2020, 47 (3) 349-353; DOI: 10.3899/jrheum.181326
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Keywords

SPONDYLOARTHRITIS
INFLAMMATORY BOWEL DISEASE
GASTROINTESTINAL DISEASES
EPIDEMIOLOGY

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