Hydroxychloroquine-induced Hyperpigmentation

A. Mottled and reticular hyperpigmented patches on the arms with focal ecchymosis. B. High-magnification H&E-stained section (original magnification ×400) showing scattered pigmented granules within the mid dermis, some seen within histiocytes. C–D. Perls’ Prussian blue (original magnification ×100) and Fontana Masson (original magnification ×400) stains reveal significant iron and melanin deposits within the dermis, respectively.