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Research ArticlePsoriatic Arthritis

Measuring Outcomes in Psoriatic Arthritis: Comparing Routine Assessment of Patient Index Data and Psoriatic Arthritis Impact of Disease

Jessica A. Walsh, Marilyn T. Wan, Christine Willinger, M. Elaine Husni, Jose U. Scher, Soumya M. Reddy and Alexis Ogdie
The Journal of Rheumatology October 2020, 47 (10) 1496-1505; DOI: https://doi.org/10.3899/jrheum.190219
Jessica A. Walsh
1J.A. Walsh, MD, MBA, A. Ogdie, MD, MSCE, Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia;
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  • ORCID record for Jessica A. Walsh
Marilyn T. Wan
2M.T. Wan, MBChB, MPH, Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia;
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Christine Willinger
3C. Willinger, BS, University of Pennsylvania, Philadelphia, Pennsylvania;
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M. Elaine Husni
4M.E. Husni, MD, MPH, Cleveland Clinic, Cleveland, Ohio;
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Jose U. Scher
5J.U. Scher, MD, S.M. Reddy MD, New York University School of Medicine, New York, New York, USA.
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Soumya M. Reddy
5J.U. Scher, MD, S.M. Reddy MD, New York University School of Medicine, New York, New York, USA.
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Alexis Ogdie
1J.A. Walsh, MD, MBA, A. Ogdie, MD, MSCE, Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia;
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  • For correspondence: alexis.ogdie@uphs.upenn.edu
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Abstract

Objective To examine the construct validity of Routine Assessment of Patient Index Data 3 (RAPID3) and Psoriatic Arthritis Impact of Disease (PsAID) in patients with psoriatic arthritis (PsA). In examining construct validity, we also addressed scores among subgroups with severe psoriasis, poly articular disease, enthesitis, and dactylitis, and evaluated influences of sociodemographic factors and comorbidities (contextual factors) on these patient-reported outcomes (PRO).

Methods Patients with PsA were enrolled in the Psoriatic Arthritis Research Consortium (PARC) between 2014 and 2016. PARC is a longitudinal observational cohort study conducted at 4 US institutions. In this cross-sectional study, construct validity was assessed by examining Spearman correlation coefficients for RAPID3 and PsAID with physician-reported disease activity measures and other PRO [e.g., Medical Outcomes Study Short Form-12 physical component summary/mental component summary (SF-12 PCS/MCS), Functional Assessment of Chronic Illness Therapy–Fatigue scale (FACIT-F)]. Contextual factors and disease subgroups were assessed in multivariable linear regression models with RAPID3 or PsAID12 as outcomes of interest and the hypothesized contextual factors as covariates.

Results Among 401 patients enrolled in PARC, 347 completed RAPID3 or PsAID12. Of these, most were white females with a mean age of 51.7 years (SD 14.02). RAPID3 and PsAID were highly correlated (r = 0.90). These measures were also correlated with the SF-12 PCS (r = −0.67) and FACIT-F (r = −0.77). Important contextual factors and disease subgroups included enthesitis, joint counts, education, insurance type, and depression.

Conclusion RAPID3 and PsAID12 have excellent construct validity in PsA and are strongly correlated despite differing items. Contextual factors (i.e., the presence of depression and obesity) should be considered when interpreting raw scores of the RAPID3 and PsAID12.

Key Indexing Terms:
  • patient-reported outcomes
  • psoriatic arthritis

Footnotes

  • Dr. Walsh has received consulting fees or research grants from AbbVie and Pfizer. Dr. Husni is a coinventor on a patent for a psoriatic arthritis questionnaire (Psoriatic Arthritis Screening Evaluation), for which she receives royalties. Dr. Scher has received consulting fees from Novartis. Dr. Ogdie has received grants from Amgen and Pfizer to the trustees of the University of Pennsylvania.

  • Supported by the US National Institutes of Health/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR072363).

  • Accepted for publication September 18, 2019.
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Measuring Outcomes in Psoriatic Arthritis: Comparing Routine Assessment of Patient Index Data and Psoriatic Arthritis Impact of Disease
Jessica A. Walsh, Marilyn T. Wan, Christine Willinger, M. Elaine Husni, Jose U. Scher, Soumya M. Reddy, Alexis Ogdie
The Journal of Rheumatology Oct 2020, 47 (10) 1496-1505; DOI: 10.3899/jrheum.190219

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Measuring Outcomes in Psoriatic Arthritis: Comparing Routine Assessment of Patient Index Data and Psoriatic Arthritis Impact of Disease
Jessica A. Walsh, Marilyn T. Wan, Christine Willinger, M. Elaine Husni, Jose U. Scher, Soumya M. Reddy, Alexis Ogdie
The Journal of Rheumatology Oct 2020, 47 (10) 1496-1505; DOI: 10.3899/jrheum.190219
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PATIENT-REPORTED OUTCOMES
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