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Research ArticleOther Arthritides

Perceptions of Pregnancy and Lactation from the Pregnancy and Lactation Autoimmune Network Registry

Brooke S. Mills, Kathryn H. Dao, Kristen M. Tecson, Emily F. Beil, Rachel Tate and John J. Cush
The Journal of Rheumatology January 2020, 47 (1) 149-154; DOI: https://doi.org/10.3899/jrheum.181067
Brooke S. Mills
From the University of Texas Southwestern; Baylor Research Institute; Baylor Heart and Vascular Institute; Texas A&M HSC College of Medicine, Dallas, Texas, USA.
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  • For correspondence: brooke.mills{at}phhs.org
Kathryn H. Dao
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Kristen M. Tecson
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Emily F. Beil
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Rachel Tate
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John J. Cush
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  • Attitudes toward pregnancy and lactation after diagnosis. The solid and dotted bars highlight those women who had more concerns about pregnancy and/or lactation after disease diagnosis. These women may have still had children. The striped bar represents those women who decided to forgo pregnancy altogether as a result of their disease diagnosis. SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; JIA: juvenile idiopathic arthritis; AS: ankylosing spondylitis.
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    Figure 1.

    Attitudes toward pregnancy and lactation after diagnosis. The solid and dotted bars highlight those women who had more concerns about pregnancy and/or lactation after disease diagnosis. These women may have still had children. The striped bar represents those women who decided to forgo pregnancy altogether as a result of their disease diagnosis. SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; JIA: juvenile idiopathic arthritis; AS: ankylosing spondylitis.

  • Percentage of reported pregnancy and lactation concerns. More than 65% of women were concerned about medication use during pregnancy adversely affecting their fetus. This was the most common concern among our respondents.
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    Figure 2.

    Percentage of reported pregnancy and lactation concerns. More than 65% of women were concerned about medication use during pregnancy adversely affecting their fetus. This was the most common concern among our respondents.

Tables

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    Table 1.

    Patient characteristics (n = 154).

    VariablesValues
    Median age, yrs38
    Diagnosis, %
      Ankylosing spondylitis7.8
      Juvenile idiopathic arthritis4.6
      Systemic lupus erythematosus23.4
      Psoriatic arthritis10.4
      Rheumatoid arthritis37.7
      Other*16.2
    • ↵* “Other” refers to patients with immune-mediated inflammatory myositis, vasculitis, systemic sclerosis, and undifferentiated connective tissue disease.

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    Table 2.

    Medication use during the childbearing process.

    MedicationsBefore Pregnancy, n = 88During Pregnancy, n = 88Breastfeeding, n = 60
    Hydroxychloroquine21 (23.9)14 (15.9)9 (15.0)
    Azathioprine0 (0.0)2 (2.3)1 (1.7)
    Mycophenolate mofetil1 (1.1)0 (0.0)0 (0.0)
    Sulfasalazine4 (4.5)2 (2.3)1 (1.7)
    Methotrexate12 (13.6)0 (0.0)0 (0.0)
    Leflunomide2 (2.3)0 (0.0)0 (0.0)
    Cyclosporine2 (2.3)0 (0.0)0 (0.0)
    Prednisone18 (20.5)14 (15.9)8 (13.3)
    NSAID27 (30.7)13 (14.8)10 (16.7)
    Etanercept15 (17.0)5 (5.7)7 (11.7)
    Infliximab3 (3.4)0 (0.0)0 (0.0)
    Adalimumab9 (10.2)3 (3.4)2 (3.3)
    Certolizumab4 (4.5)4 (4.5)3 (5.0)
    Golimumab2 (2.3)0 (0.0)0 (0.0)
    Rituximab1 (1.1)1 (1.3)1 (1.7)
    Narcotics4 (4.5)2 (2.3)0 (0.0)
    Acetaminophen24 (27.3)29 (33.0)20 (33.3)
    • Values are n (%). NSAID: nonsteroidal antiinflammatory drug.

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Perceptions of Pregnancy and Lactation from the Pregnancy and Lactation Autoimmune Network Registry
Brooke S. Mills, Kathryn H. Dao, Kristen M. Tecson, Emily F. Beil, Rachel Tate, John J. Cush
The Journal of Rheumatology Jan 2020, 47 (1) 149-154; DOI: 10.3899/jrheum.181067

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Perceptions of Pregnancy and Lactation from the Pregnancy and Lactation Autoimmune Network Registry
Brooke S. Mills, Kathryn H. Dao, Kristen M. Tecson, Emily F. Beil, Rachel Tate, John J. Cush
The Journal of Rheumatology Jan 2020, 47 (1) 149-154; DOI: 10.3899/jrheum.181067
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Keywords

PREGNANCY
RHEUMATIC DISEASES
LACTATION
PATIENT EDUCATION

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