Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticlePediatric Rheumatology

Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study

Birgit Nomeland Witczak, Siri Opsahl Hetlevik, Helga Sanner, Zoltan Barth, Thomas Schwartz, Berit Flatø, Vibke Lilleby and Ivar Sjaastad
The Journal of Rheumatology July 2019, 46 (7) 739-747; DOI: https://doi.org/10.3899/jrheum.180526
Birgit Nomeland Witczak
From the Institute for Experimental Medical Research and K.G. Jebsen Center for Cardiac Research, and the Section of Infectious Diseases, and the Department of Cardiology, Oslo University Hospital — Ullevål; University of Oslo; Department of Rheumatology, Oslo University Hospital — Rikshospitalet; Bjørknes College; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Siri Opsahl Hetlevik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Siri Opsahl Hetlevik
  • For correspondence: siri.opsahl@gmail.com
Helga Sanner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zoltan Barth
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Schwartz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Berit Flatø
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vibke Lilleby
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivar Sjaastad
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective. To assess cardiac function in patients with juvenile mixed connective tissue disease (JMCTD) compared to matched controls, and to investigate possible associations between cardiac impairment and disease variables and cardiovascular risk factors.

Methods. Fifty JMCTD patients (86% female) examined median 14.9 (6.6–23.0) years after disease onset were compared with 50 age- and sex-matched controls. Electrocardiogram and echocardiography [including e′ as a marker for diastolic dysfunction and long-axis strain (LAS) and left ventricular (LV) ejection fraction (EF) as markers of systolic function] were performed. LV dysfunction (LVD) was defined as low EF, low LAS, or low e′. Right ventricular function was assessed with tricuspid annular plane systolic excursion (TAPSE). Cardiovascular risk factors and disease variables were assessed.

Results. LVD was found in 16% of patients and 4% of controls (p = 0.035). EF and LAS were lower in patients compared to controls (6% lower, p < 0.001, and 4% lower, p = 0.044, respectively). TAPSE was 8% lower in patients versus controls (p = 0.008). No patients had signs of pulmonary hypertension. Patients had longer corrected QT time than controls (p = 0.012). LVD was associated with higher levels of apolipoprotein B, higher disease activity measured by physician’s global assessment, longer prednisolone treatment, and more organ damage assessed with the Myositis Damage Index.

Conclusion. Patients with JMCTD had impaired left and right ventricular function compared to matched controls after median 15 years disease duration. High disease activity and longer treatment with prednisolone were factors associated with LVD.

Key Indexing Terms:
  • MIXED CONNECTIVE TISSUE DISEASE
  • CARDIOVASCULAR DISEASE
  • LEFT VENTRICULAR DYSFUNCTION
  • CARDIAC DYSFUNCTION

Mixed connective tissue disease (MCTD) is a rare autoimmune disease with overlapping clinical features from systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis (PM). Common findings include Raynaud phenomenon (RP), puffy hands, arthritis, myositis, and interstitial lung disease. Increased cardiovascular morbidity and mortality in inflammatory autoimmune diseases such as idiopathic inflammatory myopathies (which include PM and dermatomyositis) and rheumatoid arthritis (RA) are well known1. The risk of cardiovascular involvement in SLE, such as ischemic heart disease, heart failure, and stroke, is up to 50-fold higher compared to the general population, and more pronounced in young individuals2,3,4. A systematic review suggested that 20% of mortality in MCTD was directly caused by cardiac disease5.

No systematic studies have assessed cardiac function in MCTD patients with juvenile presentation (JMCTD; 7–23% of all MCTD cases)6,7; because of the early onset, these patients may have an increased inflammatory burden with higher risk for development of cardiovascular disease (CVD). Some retrospective studies have shown that cardiac disease in JMCTD is more common than in adult MCTD8,9, but results are conflicting7.

Subclinical left ventricular dysfunction (LVD) is a predictor of manifest CVD and heart failure in the general population10,11. In adult MCTD and juvenile dermatomyositis (JDM), diastolic LVD has been demonstrated compared to controls12,13,14. In juvenile SLE and JDM, subclinical systolic LVD was found in patients compared to controls15,16. This was measured by global longitudinal strain (long-axis strain; LAS), which is a more sensitive echocardiographic measure than LV ejection fraction (LVEF) for detecting systolic dysfunction17.

Possible etiologies behind LVD are hypertension (HTN), coronary heart disease, obesity, dyslipidemia, and exposure to cardiotoxic drugs18. Disease activity has emerged as an independent risk factor of LVD in both RA19 and SLE patients20. Also, high early disease activity was independently associated with systolic dysfunction in JDM16. However, in MCTD this possible relationship with disease activity has not been examined.

Thus, the aim of our study was to assess cardiac function in a representative JMCTD cohort compared to age- and sex-matched controls from the general population, and to investigate possible associations between cardiac impairment and disease characteristics, activity, and damage, and traditional and disease-related cardiovascular risk factors.

MATERIALS AND METHODS

Patients and controls

This case-control study was performed at Oslo University Hospital (OUH) from March 2013 to June 2015. As previously described in detail21, different methods were used to search for patients with JMCTD in Norway. The inclusion criteria were (1) fulfillment of the Kasukawa or Alarcón-Segovia and Villareal criteria22, (2) symptom onset before age 18 years, and (3) a clinical diagnosis confirmed by a rheumatologist or pediatrician. Out of 62 patients who fulfilled the inclusion criteria, 3 were dead, 3 did not want to participate, 1 did not respond, and 3 had developed SLE and were excluded. One patient did not participate in the cardiac assessments and another patient was excluded because of an excluded control. The remaining 50 patients represent our study population.

One sex- and age-matched control per patient was randomly selected from the National Population Register and invited to participate. Exclusion criteria were a history of autoimmune disease necessitating immunosuppressive medication, and lung or heart disease, except for mild asthma and HTN.

We obtained informed consent from all patients and controls (and their parents if aged < 16 yrs), according to the Declaration of Helsinki. The study was approved by the Regional Ethics Committee for Medical Research (ID 2012/1721).

Clinical examination and cardiovascular risk assessment

In patients, clinical variables from the time of diagnosis during the entire disease course and upon examination were obtained from clinical rheumatological assessment, patient interviews, and medical records. In patients and controls, systolic (SBP) and diastolic blood pressure (DBP) were measured after a 5-min rest in a seated position. Height and weight were measured, and body mass index (BMI) was calculated. Smoking habits and level of physical activity were obtained from questionnaires. Fasting blood samples were collected and analyzed by routine laboratory methods at OUH. Serum levels of anti-RNP were determined with fluorescence enzyme immunoassay. Anti-dsDNA was detected with indirect immunofluorescence technique and fluorescence enzyme immunoassay (EliA).

Disease activity and damage

Because there are no validated criteria for remission in MCTD, we used the criteria for clinical remission in juvenile idiopathic arthritis (JIA)23, and added the absence of cytopenia, myositis, progressive lung and esophageal manifestations, and progressive sclerodactyly (with or without RP)21. Remission was defined as inactive disease with or without medication for a minimum of 6 months, and active disease as the absence of remission.

Disease activity and damage scores developed for SLE, SSc, and JIA were used, including the Systemic Lupus Erythematosus Disease Activity Index24, Rodnan skin score25, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index26, Myositis Damage Index (MDI)27, and the Juvenile Arthritis Damage Index (JADI)28.

Echocardiography and electrocardiogram (ECG)

B-mode, M-mode, and Doppler echocardiography, including early and late diastolic filling velocities, were performed by researchers (BNW, TS) blinded to disease characteristics in all participants, as previously described16. A minimum of 3 cycles were recorded, analyzed, and averaged. Data analysis (ZB) was done blinded to both clinical information and patient/control identity. Tissue Doppler was performed as previously described14. Valvular regurgitation > grade 1 was considered significant.

Low EF, LAS, and e′ were defined as mean – 2SD of the values measured in the matched controls. LVD was defined as low EF, low LAS, or low e′.

Twelve-channel ECG were recorded and accessible in 37 patients and controls aged ≥ 16 years. We assessed rhythm and ST segments, and measured PR interval, corrected QT interval (QTc), and QRS duration. ECG was classified, blinded to information about study participants including disease activity, as normal, borderline, or pathological. Standard criteria for pathological ECG were used, including Cornell voltage criteria for subjects ≥ 16 years of age29.

Statistical analysis

Differences between patients and matched controls were tested with the paired sample t test, Wilcoxon rank-sum test, or McNemar test as appropriate. Differences between patient groups were tested by the Mann-Whitney U test or the chi-square test/Fisher’s exact test as appropriate. Correlations were determined by the Pearson or Spearman correlation coefficient (ϱ), as appropriate. P < 0.05 was considered significant. Statistical analyses were performed with SPSS version 24.0 (IBM).

RESULTS

Clinical characteristics

Of the patients, 86% were female, and age at followup was median 27.2 years (interquartile range 19.4–34.1; Table 1).

View this table:
  • View inline
  • View popup
Table 1.

Characteristics of 50 patients with juvenile MCTD.

Active disease was present in 35 (70%) after median 14.9 years (6.6–23.0) of disease duration. At followup, 36 (72%) were taking immunosuppressive drugs. Calcium antagonists were used in 10 (20%; indication RP in 9 and HTN in 1). Two patients reported dyspnea at exertion: a woman aged 54 years with type 2 diabetes, HTN, and coronary artery disease, and a man aged 28 with extensive pulmonary disease. None of the controls reported cardiac-related symptoms. No study participants had known type 1 diabetes, heart failure, cardiac arrhythmias, or cerebrovascular disease.

Traditional cardiovascular risk factors in patients and controls

No significant differences were found in BMI, smoking habits, level of physical activity, or blood pressure variables between patients and controls (Table 2).

View this table:
  • View inline
  • View popup
Table 2.

Traditional cardiovascular risk factors in juvenile MCTD patients and controls.

Levels of low-density lipoproteins (LDL) and high-density lipoprotein (HDL) cholesterol were lower in patients compared to controls, with comparable HDL/LDL ratio. Apolipoprotein A-I (ApoA-I) was lower in patients than controls, without significant difference in ApoB/ApoA-I ratio. Fasting glucose, glycosylated hemoglobin, and C-reactive protein (CRP) were not significantly different between the groups, but erythrocyte sedimentation rate was higher in patients (Table 2).

ECG in patients and controls

Pathological ECG was found in 7/37 patients and 2/37 controls (p = 0.090). Pathological ECG in the patients included poor R-wave progression (n = 2), LV hypertrophy signs (n = 4), right-axis deviation (n = 2), and pathological Q-wave (n = 2); in the controls, right-axis deviation (n = 1) and LV hypertrophy (n = 1). Patients had longer QTc compared to controls (417.7 vs 408.7 ms, p = 0.012).

Echocardiographic findings in JMCTD patients and controls

Systolic function measured by EF and LAS were lower in patients compared to controls (6% lower, p < 0.001, and 4% lower, p = 0.044, respectively; Table 3).

View this table:
  • View inline
  • View popup
Table 3.

Comparison of echocardiographic variables and 12-channel electrocardiography in juvenile MCTD patients versus controls at examination after a median 14.9 years of disease duration.

None of the patients and controls had clinically pathological LVEF (< 50%). No significant difference in diastolic function measured by e′ was found between the groups. Tricuspid annular plane systolic excursion (TAPSE), a measure for right ventricular (RV) function, was 8% lower in patients than controls (p = 0.008). However, we found no indication of elevated RV pressure in any patients or controls, including normal right atrial size.

LVD was found in 8/50 (16%) of patients versus 2/50 (4%) of controls (p = 0.035; Figure 1A and 1B). Low EF (< 61.6%) was found in 7 (14%) of patients versus 0 of controls (p = 0.006), low LAS (≤ 15.3%) in 2 (4%) of patients versus 1 (2%) of controls (p = 0.500), and low e′ (≤ 9.3) in 1 patient (2%) and 1 (2%) of the controls (p = 1.000).

Figure 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1.

Left ventricular (LV) function in patients with JMCTD after a median 14.9 years of disease duration (A), and in controls (B). JMCTD: juvenile mixed connective tissue disease.

When comparing echocardiographic findings in patients with active and inactive disease, no significant differences were found (data not shown).

Associations between LVD and patient characteristics, CVD risk factors, and medication in JMCTD patients

When comparing patients with LVD (n = 8) with patients with normal LV function (n = 42), no significant difference in characteristics or antibody profile were found (Table 4). One patient tested positive for anti-SSA, 1 for anti-SSB, and none for myositis-specific autoantibodies. Regarding cardiovascular risk factors, patients with LVD had higher SBP, DBP, and ApoB. Also, patients with LVD had higher disease activity measured by physician’s global assessment (PGA), but other measures of disease activity did not differ significantly between the 2 groups. Organ damage assessed with MDI was higher in patients with LVD. Patients with LVD also used calcium channel blockers more often and had used steroids 4.5 times longer than patients with normal LV function (Table 4). In patients, the use of calcium channel blockers showed a positive correlation with RP symptoms assessed with a visual analog scale (ρ 0.35, p = 0.016).

View this table:
  • View inline
  • View popup
Table 4.

Patient and disease characteristics in 50 patients with juvenile MCTD according to left ventricular function.

Associations between LVD and early disease variables assessed in patients

PM-like disease and muscle weakness at diagnosis was more often found in patients with LVD than in patients with normal LV function after median 14.9 years (Table 5). Also, CRP was higher the first year postdiagnosis in patients with LVD. We found no association with LVD regarding age, typical MCTD symptoms, or signs such as puffy hands, RP, RF positivity, SLE-like disease, and SSc-like disease at diagnosis.

View this table:
  • View inline
  • View popup
Table 5.

Variables from time of diagnosis in 49 juvenile MCTD patients according to left ventricular function at examination after a median 14.9 years of disease duration.

DISCUSSION

In this longterm outcome study of cardiac function in JMCTD, we found impaired LV systolic function measured by EF and LAS in patients compared to controls. Patients with LVD had higher disease activity, more disease damage, and had been treated with steroids for a longer time. Also, we found that PM-like disease, high CRP, or treatment with high doses of steroids at diagnosis were factors associated with LVD after a median 15 years disease duration. To our knowledge, this is the first systematic case-control study on cardiac function in patients with JMCTD.

A strength of our study was that the cohort is believed to be representative of JMCTD patients living in Norway, as previously described in detail21. The female predominance and age at diagnosis correspond well with previous studies30. Our controls were comparable to the patients regarding BMI, level of physical activity, and smoking habits.

Our study revealed impaired systolic function measured by LAS and EF in patients with JMCTD compared to controls, despite their young age (median 27.2 yrs). The impairment was subclinical in all but 1 patient. Diastolic function was not significantly different in patients and controls, although the study might be underpowered. In accordance with these results, 2 previous studies have described presence of LVD in adult patients with MCTD12,13. However, in contrast to our findings, Vegh, et al found a preserved systolic function12, and both previous studies found impaired diastolic function measured by mitral valve (MV) E/A ratio. Several reasons may contribute to the different findings. First, the other studies involved adult MCTD, while our cohort was JMCTD. Second, we used LAS to reveal systolic dysfunction, which is regarded as a more sensitive and robust marker of systolic dysfunction than EF31. Third, we used e′ to assess diastolic dysfunction, a more accurate marker compared to MV E/A ratio, because it is less load-dependent32. Although our results in fact did show a slightly lower MV E/A ratio in patients versus controls, in isolation this should not be interpreted as diastolic dysfunction in patients with LVEF > 50%33. The fourth reason is the major differences among the study populations: Vegh, et al reported 21 of 50 patients having signs of pulmonary arterial HTN (PAH) during the past 2 years and 20 patients had been treated with cyclophosphamide, indicating a patient population biased toward more severe cases compared to ours12. LVD has also been shown in juvenile SLE as well as in JDM14,15. The prognostic and predictive values of subclinical LVD in JMCTD require further study.

We also found that patients with JMCTD had reduced RV function assessed with TAPSE. In adult MCTD patients with PAH, impairment of RV function has previously been demonstrated, while the patients without PAH had RV function similar to controls12. In line with our results, Leal, et al reported subclinical RV systolic dysfunction in juvenile patients with SLE, even after excluding patients with PAH34. They found that RV dysfunction was associated with antiphospholipid antibodies (aPL). No such association between RV or LV dysfunction and the presence of aPL was found in our patients. None of our patients had elevated right arterial pressure at examination, or other signs of PAH. We have previously reported a frequency of clinically overt PAH of 3.4% in the present JMCTD cohort21. However, one of the 2 patients had died before inclusion, and the other had reversible symptoms and normal cardiac function at the time of examination. Thus, the present echocardiographic results support our previous finding that the occurrence of PAH in an unselected JMCTD cohort is low, in accordance with reports in adult MCTD35. Further, our data suggest that subclinical RV impairment in JMCTD is unlikely to be due to PH.

Possible mechanisms behind LVD in patients with autoimmune diseases are many, and among them, dyslipidemia is known to play a role. Our JMCTD cohort had lower HDL and ApoA-I compared to controls, and both variables have been shown to be inversely related to the risk of CVD36,37. In line with our results, lower ApoA-I in adult patients with MCTD compared to controls has been reported38. However, they found similar HDL and LDL levels in patients and controls. Unexpectedly, we found lower LDL in patients compared to controls; however, in patients with RA or JDM, a so-called lipid paradox has previously been described, with lower levels of LDL and total cholesterol, but still an association with higher CVD risk or cardiac dysfunction39,40.

Additionally, we found that patients with LVD had higher ApoB levels compared to those with normal cardiac function. We found no significant differences in HDL, LDL, ApoA-I, or triglycerides levels, which might be due to a type 2 error, and/or the complex relationship between dyslipidemia, inflammation, and CV risk in MCTD.

Inflammation plays a significant role in CVD41,42. Our data show a similar relationship in JMCTD, because patients with LVD had higher disease activity according to PGA, longer treatment with corticosteroids, and a trend toward a higher CRP and number of active joints early in the disease course. Also, the increased MDI and borderline increased JADI in patients with LVD possibly reflects a longer active inflammatory disease course, causing irreversible joint and organ damage, and possibly cardiac damage. In RA, higher disease activity has been shown to be associated with reduced LV function independently of cardiovascular risk factors19, and in juvenile SLE, higher disease activity contributed to myocardial impairment15, which is in line with our findings.

The majority of patients with LVD at examination had PM-like disease with muscle weakness at diagnosis, and we also found an association between PM-like disease and pathological ECG. It is known that patients with JDM have both diastolic and systolic dysfunction after longterm followup14,16. Although the sample size is too small to draw conclusions, it might be that the subset of JMCTD patients with PM-like onset has similarities in pathogenesis with JDM patients.

No valvular abnormalities were observed, as opposed to what has been reported in adult-onset MCTD5. However, this was similar to findings in other juvenile CTD43,44, and might be explained by the young age of the cohort.

A limitation of our study is the relatively small sample size of patients and controls, which may underestimate differences between the groups. The comparisons between patients with and without LVD must be interpreted with care, because the group with LVD comprises only 8 patients and p values could be due to chance alone. However, the relationships are interesting and should be assessed in future studies. Assessing disease activity and damage in MCTD is difficult, because there are no validated scores available for the disease. Thus, we had to use surrogate measures to record the broad spectrum of disease activity and damage seen in MCTD as comprehensively as possible.

To our knowledge, our present study is the first to systematically examine cardiac manifestations in an unselected cohort of patients with JMTCD. The patients have a long followup time despite young age, and the case-control design is well suited to detect subclinical manifestations. We used state-of-the-art methods, such as strain imaging of both the RV and LV, to detect subclinical cardiac dysfunction. This method is more accurate and sensitive than LVEF measurements31.

In this longterm study, we found that patients with JMCTD had impaired LV systolic function and RV function, but preserved diastolic LV function compared to matched controls after a median 15 years of disease duration. Factors associated with LVD were high disease activity, longer treatment with prednisolone, and PM-like disease at diagnosis. Cardiac manifestations in our JMCTD cohort were mostly subclinical. Further prospective studies are needed to evaluate the prognostic implication of subclinical LVD in JMCTD.

Acknowledgment

We thank Helga Sørhøy for practical assistance in examining the patients, Torhild Garen for help with preparation of questionnaires, and Øyvind Molberg and Inge-Margrethe Gilboe for administrative support.

Footnotes

  • This study was funded by The Norwegian Rheumatism Association and made possible by the Norwegian ExtraFoundation for Health and Rehabilitation.

  • Accepted for publication November 8, 2018.

REFERENCES

  1. 1.↵
    1. Nurmohamed MT,
    2. Heslinga M,
    3. Kitas GD
    . Cardiovascular comorbidity in rheumatic diseases. Nat Rev Rheumatol 2015;11:693–704.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Manzi S,
    2. Meilahn EN,
    3. Rairie JE,
    4. Conte CG,
    5. Medsger TA Jr,
    6. Jansen-McWilliams L,
    7. et al.
    Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study. Am J Epidemiol 1997;145:408–15.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Bjornadal L,
    2. Yin L,
    3. Granath F,
    4. Klareskog L,
    5. Ekbom A
    . Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964–95. J Rheumatol 2004;31:713–9.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Symmons DP,
    2. Gabriel SE
    . Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE. Nat Rev Rheumatol 2011;7:399–408.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Ungprasert P,
    2. Wannarong T,
    3. Panichsillapakit T,
    4. Cheungpasitporn W,
    5. Thongprayoon C,
    6. Ahmed S,
    7. et al.
    Cardiac involvement in mixed connective tissue disease: a systematic review. Int J Cardiol 2014;171:326–30.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Burdt MA,
    2. Hoffman RW,
    3. Deutscher SL,
    4. Wang GS,
    5. Johnson JC,
    6. Sharp GC
    . Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings. Arthritis Rheum 1999;42:899–909.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Kotajima L,
    2. Aotsuka S,
    3. Sumiya M,
    4. Yokohari R,
    5. Tojo T,
    6. Kasukawa R
    . Clinical features of patients with juvenile onset mixed connective tissue disease: analysis of data collected in a nationwide collaborative study in Japan. J Rheumatol 1996;23:1088–94.
    OpenUrlPubMed
  8. 8.↵
    1. Singsen BH,
    2. Bernstein BH,
    3. Kornreich HK,
    4. King KK,
    5. Hanson V,
    6. Tan EM
    . Mixed connective tissue disease in childhood. A clinical and serologic survey. J Pediatr 1977;90:893–900.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Yokota S
    . Mixed connective tissue disease in childhood. Acta Paediatr Jpn 1993;35:472–9.
    OpenUrlPubMed
  10. 10.↵
    1. Echouffo-Tcheugui JB,
    2. Erqou S,
    3. Butler J,
    4. Yancy CW,
    5. Fonarow GC
    . Assessing the risk of progression from asymptomatic left ventricular dysfunction to overt heart failure: a systematic overview and meta-analysis. JACC Heart Fail 2016;4:237–48.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Russo C,
    2. Jin Z,
    3. Elkind MS,
    4. Rundek T,
    5. Homma S,
    6. Sacco RL,
    7. et al.
    Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort. Eur J Heart Fail 2014;16:1301–9.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Vegh J,
    2. Hegedus I,
    3. Szegedi G,
    4. Zeher M,
    5. Bodolay E
    . Diastolic function of the heart in mixed connective tissue disease. Clin Rheumatol 2007;26:176–81.
    OpenUrlPubMed
  13. 13.↵
    1. Leung WH,
    2. Wong KL,
    3. Lau CP,
    4. Wong CK,
    5. Cheng CH,
    6. Tai YT
    . Doppler-echo evaluation of left ventricular diastolic filling in patient with mixed connective tissue disease. Cardiology 1990;77:93–100.
    OpenUrlPubMed
  14. 14.↵
    1. Schwartz T,
    2. Sanner H,
    3. Husebye T,
    4. Flato B,
    5. Sjaastad I
    . Cardiac dysfunction in juvenile dermatomyositis: a case-control study. Ann Rheum Dis 2011;70:766–71.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Leal GN,
    2. Silva KF,
    3. Lianza AC,
    4. Giacomin MF,
    5. Andrade JL,
    6. Kozu K,
    7. et al.
    Subclinical left ventricular dysfunction in childhood-onset systemic lupus erythematosus: a two-dimensional speckle-tracking echocardiographic study. Scand J Rheumatol 2016;45:202–9.
    OpenUrl
  16. 16.↵
    1. Schwartz T,
    2. Sanner H,
    3. Gjesdal O,
    4. Flato B,
    5. Sjaastad I
    . In juvenile dermatomyositis, cardiac systolic dysfunction is present after long-term follow-up and is predicted by sustained early skin activity. Ann Rheum Dis 2014;73:1805–10.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Gjesdal O,
    2. Vartdal T,
    3. Hopp E,
    4. Lunde K,
    5. Brunvand H,
    6. Smith HJ,
    7. et al.
    Left ventricle longitudinal deformation assessment by mitral annulus displacement or global longitudinal strain in chronic ischemic heart disease: are they interchangeable? J Am Soc Echocardiogr 2009;22:823–30.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Metra M,
    2. Teerlink JR
    . Heart failure. Lancet 2017;390:1981–95.
    OpenUrl
  19. 19.↵
    1. Midtbo H,
    2. Semb AG,
    3. Matre K,
    4. Kvien TK,
    5. Gerdts E
    . Disease activity is associated with reduced left ventricular systolic myocardial function in patients with rheumatoid arthritis. Ann Rheum Dis 2017;76:371–6.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Huang BT,
    2. Yao HM,
    3. Huang H
    . Left ventricular remodeling and dysfunction in systemic lupus erythematosus: a three-dimensional speckle tracking study. Echocardiography 2014;31:1085–94.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Hetlevik SO,
    2. Flatø B,
    3. Rygg M,
    4. Nordal EB,
    5. Brunborg C,
    6. Hetland H,
    7. et al.
    Long-term outcome in juvenile-onset mixed connective tissue disease: a nationwide Norwegian study. Ann Rheum Dis 2017;76:159–65.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Kasukawa RS,
    2. Gordon C
    . Mixed connective tissue disease and anti-nuclear antibodies: proceedings of the International Symposium on Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Tokyo, 29–30 August 1986. New York: Excerpta Medica; 1987.
  23. 23.↵
    1. Wallace CA,
    2. Ruperto N,
    3. Giannini E;
    4. Childhood Arthritis and Rheumatology Research Alliance;
    5. Pediatric Rheumatology International Trials Organization;
    6. Pediatric Rheumatology Collaborative Study Group
    . Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol 2004;31:2290–4.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Bombardier C,
    2. Gladman DD,
    3. Urowitz MB,
    4. Caron D,
    5. Chang CH
    . Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 1992;35:630–40.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Furst DE,
    2. Clements PJ,
    3. Steen VD,
    4. Medsger TA Jr,
    5. Masi AT,
    6. D’Angelo WA,
    7. et al.
    The modified Rodnan skin score is an accurate reflection of skin biopsy thickness in systemic sclerosis. J Rheumatol 1998;25:84–8.
    OpenUrlPubMed
  26. 26.↵
    1. Gladman D,
    2. Ginzler E,
    3. Goldsmith C,
    4. Fortin P,
    5. Liang M,
    6. Urowitz M,
    7. et al.
    The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 1996;39:363–9.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Isenberg DA,
    2. Allen E,
    3. Farewell V,
    4. Ehrenstein MR,
    5. Hanna MG,
    6. Lundberg IE,
    7. et al;
    8. International Myositis and Clinical Studies Group (IMACS)
    . International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease. Rheumatology 2004;43:49–54.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Viola S,
    2. Felici E,
    3. Magni-Manzoni S,
    4. Pistorio A,
    5. Buoncompagni A,
    6. Ruperto N,
    7. et al.
    Development and validation of a clinical index for assessment of long-term damage in juvenile idiopathic arthritis. Arthritis Rheum 2005;52:2092–102.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Mirvis DM,
    2. Goldberger AL
    . Electrocardiography. In: Libby P, Bonow RO, Mann DL, Zipes DP, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine. Philadelphia: Saunders Elsevier; 2008:145–94.
  30. 30.↵
    1. Mier RJ,
    2. Shishov M,
    3. Higgins GC,
    4. Rennebohm RM,
    5. Wortmann DW,
    6. Jerath R,
    7. et al.
    Pediatric-onset mixed connective tissue disease. Rheum Dis Clin North Am 2005;31:483–96.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Ito K,
    2. Noma M,
    3. Mohri M,
    4. Abe K,
    5. Yamamoto U,
    6. Kikuchi K,
    7. et al.
    Mitral annulus displacement measured by tissue-tracking method with Doppler-tissue images is a useful marker of the severity of heart failure. J Cardiol 2007;50:159–66.
    OpenUrlPubMed
  32. 32.↵
    1. Nagueh SF,
    2. Middleton KJ,
    3. Kopelen HA,
    4. Zoghbi WA,
    5. Quiñones MA
    . Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527–33.
    OpenUrlFREE Full Text
  33. 33.↵
    1. Nagueh SF,
    2. Smiseth OA,
    3. Appleton CP,
    4. Byrd BF 3rd,
    5. Dokainish H,
    6. Edvardsen T,
    7. et al.
    Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2016;29:277–314.
    OpenUrlCrossRefPubMed
  34. 34.↵
    1. Leal GN,
    2. Silva KF,
    3. Franca CM,
    4. Lianza AC,
    5. Andrade JL,
    6. Campos LM,
    7. et al.
    Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: insights from two-dimensional speckle-tracking echocardiography. Lupus 2015;24:613–20.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Gunnarsson R,
    2. Andreassen AK,
    3. Molberg O,
    4. Lexberg AS,
    5. Time K,
    6. Dhainaut AS,
    7. et al.
    Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature. Rheumatology 2013;52:1208–13.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Erqou S,
    2. Kaptoge S,
    3. Perry PL,
    4. Di Angelantonio E,
    5. Thompson A,
    6. White IR,
    7. et al.
    Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 2009;302:412–23.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. McQueen MJ,
    2. Hawken S,
    3. Wang X,
    4. Ounpuu S,
    5. Sniderman A,
    6. Probstfield J,
    7. et al;
    8. INTERHEART study investigators
    . Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study. Lancet 2008;372:224–33.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Soltesz P,
    2. Bereczki D,
    3. Szodoray P,
    4. Magyar MT,
    5. Der H,
    6. Csipo I,
    7. et al.
    Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease. Arthritis Res Ther 2010;12:R78.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Myasoedova E,
    2. Crowson CS,
    3. Kremers HM,
    4. Roger VL,
    5. Fitz-Gibbon PD,
    6. Therneau TM,
    7. et al.
    Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease. Ann Rheum Dis 2011;70:482–7.
    OpenUrlAbstract/FREE Full Text
  40. 40.↵
    1. Schwartz T,
    2. Sjaastad I,
    3. Flato B,
    4. Vistnes M,
    5. Christensen G,
    6. Sanner H
    . In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction. Rheumatology 2014;53:2214–22.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Libby P
    . Atherosclerosis: disease biology affecting the coronary vasculature. Am J Cardiol 2006;98:3Q–9Q.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Willerson JT,
    2. Ridker PM
    . Inflammation as a cardiovascular risk factor. Circulation 2004;109:II2–10.
    OpenUrlCrossRefPubMed
  43. 43.↵
    1. Al-Abbad AJ,
    2. Cabral DA,
    3. Sanatani S,
    4. Sandor GG,
    5. Seear M,
    6. Petty RE,
    7. et al.
    Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus. Lupus 2001;10:32–7.
    OpenUrlCrossRefPubMed
  44. 44.↵
    1. Guevara JP,
    2. Clark BJ,
    3. Athreya BH
    . Point prevalence of cardiac abnormalities in children with systemic lupus erythematosus. J Rheumatol 2001;28:854–9.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 46, Issue 7
1 Jul 2019
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
Birgit Nomeland Witczak, Siri Opsahl Hetlevik, Helga Sanner, Zoltan Barth, Thomas Schwartz, Berit Flatø, Vibke Lilleby, Ivar Sjaastad
The Journal of Rheumatology Jul 2019, 46 (7) 739-747; DOI: 10.3899/jrheum.180526

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
Birgit Nomeland Witczak, Siri Opsahl Hetlevik, Helga Sanner, Zoltan Barth, Thomas Schwartz, Berit Flatø, Vibke Lilleby, Ivar Sjaastad
The Journal of Rheumatology Jul 2019, 46 (7) 739-747; DOI: 10.3899/jrheum.180526
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Acknowledgment
    • Footnotes
    • REFERENCES
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters

Keywords

MIXED CONNECTIVE TISSUE DISEASE
CARDIOVASCULAR DISEASE
LEFT VENTRICULAR DYSFUNCTION
CARDIAC DYSFUNCTION

Related Articles

Cited By...

More in this TOC Section

  • Epidermal Neurite Density in Skin Biopsies From Patients With Juvenile Fibromyalgia
  • Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis
  • The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis: A Randomized, Double-blind, Placebo-controlled Feasibility Study
Show more Pediatric Rheumatology

Similar Articles

Keywords

  • MIXED CONNECTIVE TISSUE DISEASE
  • cardiovascular disease
  • LEFT VENTRICULAR DYSFUNCTION
  • CARDIAC DYSFUNCTION

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire