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Research ArticlePsoriatic Arthritis

Burden and Disease Characteristics of Patients with Psoriatic Arthritis: A Population-based Cross-sectional Study

Hasan G. Tekin, Jashin J. Wu, Russel Burge, Julie Birt and Alexander Egeberg
The Journal of Rheumatology July 2019, 46 (7) 716-720; DOI: https://doi.org/10.3899/jrheum.180670
Hasan G. Tekin
From the Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Kaiser Permanente Los Angeles Medical Center, Department of Dermatology, Los Angeles, California; Eli Lilly and Co., Indianapolis, Indiana; Division of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
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Jashin J. Wu
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Russel Burge
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Julie Birt
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Alexander Egeberg
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  • For correspondence: alexander.egeberg@gmail.com
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    Table 1.

    Demographic characteristics and comorbidities of PsA by severity.

    CharacteristicsMild PsA, n = 5611Moderate PsA, n = 3479Severe PsA, n = 1487p
    Age, yrs, mean (SD)57.0 (14.5)57.9 (13.6)53.7 (12.8)< 0.001
    Women3278 (58.4)2080 (59.8)810 (54.5)0.002
    Men2333 (41.6)1399 (40.2)677 (45.5)
    Socioeconomic status< 0.001
      Lowest308 (5.5)154 (4.4)68 (4.6)
      Below average1329 (23.7)900 (25.9)277 (18.6)
      Average1440 (25.7)964 (27.7)402 (27.0)
      Above average1322 (23.6)816 (23.5)398 (26.8)
      Highest1212 (21.6)645 (18.5)342 (23.0)
    Time since diagnosis, yrs, mean (SD)8.9 (7.0)10.1 (6.2)10.5 (6.0)< 0.001
    Smoking945 (16.8)592 (17.0)233 (15.7)0.483
    Alcohol abuse415 (7.4)200 (5.8)89 (6.0)0.005
    Hypertension488 (8.7)310 (8.9)112 (7.5)0.266
    Diabetes631 (11.3)426 (12.2)167 (11.2)0.318
    CCI score, mean (SD)0.3 (0.8)0.3 (0.9)0.3 (0.8)< 0.001
    Crohn disease38 (0.7)26 (0.8)11 (0.7)0.917
    Ulcerative colitis42 (0.8)35 (1.0)16 (1.1)0.301
    Peripheral vascular disease47 (0.8)35 (1.0)11 (0.7)0.581
    Cerebrovascular disease124 (2.2)93 (2.7)23 (1.6)0.046
    Ischemic heart disease203 (3.6)151 (4.1)64 (4.2)0.446
    Previous myocardial infarction56 (1.0)47 (1.4)24 (1.6)0.093
    Cardiac dysrythmia208 (3.7)138 (4.0)39 (2.6)0.063
    Antidepressant drug use709 (12.6)444 (12.8)200 (13.5)0.704
      SSRI519 (9.3)308 (8.9)134 (9.1)0.810
      TCA222 (4.0)158 (4.5)76 (5.1)0.107
      SNRI385 (6.9)278 (8.0)91 (6.1)0.033
      Other3 (0.1)0 (0.0)< 3*0.364
    Antipsychotics218 (3.9)119 (3.4)48 (3.2)0.340
    Anxiolytic drug use219 (3.9)137 (3.9)50 (3.4)0.586
    Psychologist consultation136 (2.4)51 (1.5)47 (3.2)< 0.001
    Psychiatrist consultation86 (1.5)44 (1.3)26 (1.8)0.337
    Any psoriasis3779 (67.4)2303 (66.2)1075 (72.3)< 0.001
    Dermatologist-diagnosed psoriasis1552 (27.7)687 (19.8)531 (35.7)< 0.001
      Mild psoriasis656 (11.7)355 (10.2)277 (18.6)
      Moderate psoriasis578 (10.3)236 (6.8)140 (9.4)
      Severe psoriasis318 (5.7)96 (2.8)114 (7.7)
    • Data are n (%) unless otherwise specified.

    • ↵* Data shown as < 3 because of data security requirements. PsA: psoriatic arthritis; CCI: Charlson Comorbidity Index; SSRI: selective serotonin reuptake inhibitors; TCA: tricyclic antidepressants; SNRI: serotonin norepinephrine reuptake inhibitor.

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    Table 2.

    Prevalence of PsA among patients with psoriasis.

    VariablesPsoriasisp
    Mild, n = 11,341Moderate, n = 6690Severe, n = 1431
    Any diagnosis of PsA1845 (16.3)1359 (20.3)685 (47.9)< 0.001
    Rheumatologist-diagnosed PsA1288 (11.4)954 (14.3)528 (36.9)< 0.001
      Mild PsA656 (5.8)578 (8.6)318 (22.2)
      Moderate PsA355 (3.1)236 (3.5)96 (6.7)
      Severe PsA277 (2.4)140 (2.1)114 (8.0)
    • Data are n (%). PsA: psoriatic arthritis.

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The Journal of Rheumatology
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1 Jul 2019
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Burden and Disease Characteristics of Patients with Psoriatic Arthritis: A Population-based Cross-sectional Study
Hasan G. Tekin, Jashin J. Wu, Russel Burge, Julie Birt, Alexander Egeberg
The Journal of Rheumatology Jul 2019, 46 (7) 716-720; DOI: 10.3899/jrheum.180670

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Burden and Disease Characteristics of Patients with Psoriatic Arthritis: A Population-based Cross-sectional Study
Hasan G. Tekin, Jashin J. Wu, Russel Burge, Julie Birt, Alexander Egeberg
The Journal of Rheumatology Jul 2019, 46 (7) 716-720; DOI: 10.3899/jrheum.180670
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Keywords

PSORIATIC ARTHRITIS
PSORIASIS
DISEASE BURDEN
EPIDEMIOLOGY

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