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LetterLetter

Functional Significance of the C324R Mutation Examined Using a Structural Biological Approach

GEORGE N. GOULIELMOS, MARIA I. ZERVOU and ELIAS ELIOPOULOS
The Journal of Rheumatology June 2019, 46 (6) 654-655; DOI: https://doi.org/10.3899/jrheum.181346
GEORGE N. GOULIELMOS
Professor of Human Molecular Genetics, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion;
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  • For correspondence: goulielmos@med.uoc.gr
MARIA I. ZERVOU
Laboratory Teaching Staff, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion;
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ELIAS ELIOPOULOS
Professor of Biochemistry, Department of Biotechnology, Agricultural University of Athens, Athens, Greece.
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REFERENCES

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    1. Maeshima K,
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    . STAT dynamics. Cytokine Growth Factor Rev2007;18:511–8.
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    . Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype. Blood2016;127:3154–64.
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    1. Vinkemeier U,
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    DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J1996;15:5616–26.
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    1. Xu X,
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    . Cooperative DNA binding and sequence-selective recognition conferred by the STAT aminoterminal domain. Science1996;273:794–7.
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    1. Schrödinger LLC
    . The PyMOL Molecular Graphics System 2016; version 2.2. [Internet. Accessed March 5, 2019.] Available from: pymol.org/2/support.html
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    1. Chen X,
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    . Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell1998;93:827–39.
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1 Jun 2019
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Functional Significance of the C324R Mutation Examined Using a Structural Biological Approach
GEORGE N. GOULIELMOS, MARIA I. ZERVOU, ELIAS ELIOPOULOS
The Journal of Rheumatology Jun 2019, 46 (6) 654-655; DOI: 10.3899/jrheum.181346

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Functional Significance of the C324R Mutation Examined Using a Structural Biological Approach
GEORGE N. GOULIELMOS, MARIA I. ZERVOU, ELIAS ELIOPOULOS
The Journal of Rheumatology Jun 2019, 46 (6) 654-655; DOI: 10.3899/jrheum.181346
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