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Research ArticleOsteoarthritis

Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study

Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli and David J. Hunter
The Journal of Rheumatology November 2019, 46 (11) 1524-1530; DOI: https://doi.org/10.3899/jrheum.181406
Kai Fu
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
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  • For correspondence: kafu7690@uni.sydney.edu.au
Joanna Makovey
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Ben Metcalf
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Kim L. Bennell
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Yuqing Zhang
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Rebecca Asher
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Sarah R. Robbins
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Leticia A. Deveza
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Peter A. Cistulli
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David J. Hunter
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Article Figures & Data

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    Table 1.

    Baseline characteristics of the participants.

    CharacteristicAll Participants, n = 252Participants*, n = 130p**
    Age, yrs62.2 ± 8.362.5 ± 8.10.54
    Female, n (%)199 (79)111 (85.4)0.01
    Body mass index, kg/m228.7 ± 6.129.0 ± 6.30.34
    Index hip right, n (%)143 (56.7)72 (55.4)0.65
    Race, n (%)
      White242 (96)123 (95)0.53
      Others10 (4)7 (5)
    Education, n (%)
      Less than high school37 (14.7)21 (16.2)0.61
      Completed high school58 (23)27 (20.7)
      Higher than high school157 (62.3)82 (63.1)
    Occupational physical workload level, n (%)
      Sedentary (mostly sitting)111 (44)52 (40)0.12
      Standing occupation, physically light90 (35.7)51 (39.2)
      Manual work47 (18.7)24 (18.5)
      Heavy manual work4 (1.6)3 (2.3)
    Baseline pain level (0–10)
      Mildest2.3 ± 1.92.5 ± 2.10.02
      Worst7.6 ± 1.98.0 ± 1.80.02
    Night pain level (0–4)1.8 ± 1.01.9 ± 1.00.03
    Hip injury and Osteoarthritis Outcome Score
      Pain55.5 ± 17.352.0 ± 18.00.001
      Symptoms53.0 ± 19.450.5 ± 20.40.03
      Activities of daily living59.4 ± 21.754.7 ± 21.9< 0.001
      Sports/recreation36.5 ± 27.132.7 ± 26.60.02
      Quality of life41.5 ± 19.638.1 ± 20.70.004
    International Physical Activity Questionnaire score (range 1–3); median (IQR)3 (2)3 (2)0.53
    • Data are mean ± SD unless otherwise indicated.

    • ↵* With both case and control periods.

    • ↵** Independent sample t test, chi-square test, and nonparametric test were performed between participants with both case/control periods (n = 130) and those without (n = 122). IQR: interquartile range.

    • View popup
    Table 2.

    Pittsburgh Sleep Quality Index (PSQI) and global fatigue index (GFI) scores and subscales, and sleep disturbance components from the PSQI (130 participants).

    Scoring (range)*Median (IQR)
    Global PSQI score (0–21)8 (7); mean 8.3 ± 4.7
      Sleep duration (0–3)0 (1)
      Sleep disturbance (0–3)2 (1)
      Sleep latency (0–3)1 (1)
      Daytime dysfunction (0–3)1 (2)
      Sleep efficiency (0–3)1 (3)
      Sleep quality (0–3)1 (1)
    Sleep medication (0–3)0 (1)
      GFI score (1–51)19 (21.2); mean 18.6 ± 12.7
      Fatigue degree (1–10)6 (3)
      Fatigue severity (1–10)5 (4)
      Distress (1–10)3 (4)
      Impact on daily living (0–10)1.7 (2.3)
      Frequency (1–4)3 (2)
    • ↵* For a range of 0–3 in PSQI subscales, 0 = better, 3 = worse; for GFI score, higher score represents greater fatigue severity. Fatigue degree and effect on daily living have anchors of “Not at all” (1 or 0) to “A great deal” (10); fatigue severity has anchors of “Mild” (1) to “Severe” (10); and distress has anchors of “No distress” (1) to “A great deal of distress” (10). Frequency ranged from “Hardly any days” (1) to “Every day” (4). IQR: interquartile range.

    • View popup
    Table 3.

    Univariate association of sleep quality, sleep duration, and fatigue and hip pain exacerbation (130 participants). Three separate models were used to test the association using conditional logistic regression (univariable and multivariable).

    Independent VariablesCase Periods (%)Control Periods (%)OR (95% CI)p
    Sleep quality*
      Good91 (31)276 (34)1.0 (reference)
      Poor205 (69)532 (66)1.72 (1.04–2.86)0.036
    Sleep duration**, hrs
      ≥ 6195 (66)653 (81)1.0 (reference)
      < 6101 (34)155 (19)1.40 (0.78–2.51)0.254
    Fatigue***
      No125 (42)446 (55)1.0 (reference)
      Yes173 (58)361 (45)1.92 (1.21–3.05)0.006
    • ↵* Association of sleep quality and pain exacerbation. A global Pittsburgh Sleep Quality Index score ≤ 5 indicates good sleep quality, and > 5 indicates poor sleep quality. Two case periods were lost during followup.

    • ↵** Association of sleep duration and pain exacerbation.

    • ↵*** Association of fatigue and pain exacerbation. A cutoff score of 21 on the global fatigue index was used to detect significant fatigue. One control period was lost during followup.

    • View popup
    Table 4.

    Multivariable association of sleep quality and fatigue and hip pain exacerbations in 1 model.

    Independent VariablesOR (95% CI)*p
    Sleep quality
      Good1.0 (reference)
      Poor2.71 (1.42–5.16)0.003
    Fatigue
      No1.0 (reference)
      Yes2.55 (1.41–4.63)0.002
    • ↵* Adjusted for physical activity level and night pain level and the interaction term included.

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The Journal of Rheumatology
Vol. 46, Issue 11
1 Nov 2019
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Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study
Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli, David J. Hunter
The Journal of Rheumatology Nov 2019, 46 (11) 1524-1530; DOI: 10.3899/jrheum.181406

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Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study
Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli, David J. Hunter
The Journal of Rheumatology Nov 2019, 46 (11) 1524-1530; DOI: 10.3899/jrheum.181406
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Keywords

OSTEOARTHRITIS
PAIN
SLEEP
FATIGUE
CROSSOVER STUDIES

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