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Research ArticleRheumatoid Arthritis

HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis

Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto and Keishi Fujio
The Journal of Rheumatology July 2018, 45 (7) 905-914; DOI: https://doi.org/10.3899/jrheum.170909
Keiichi Sakurai
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
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Kazuyoshi Ishigaki
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Hirofumi Shoda
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Yasuo Nagafuchi
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Yumi Tsuchida
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Shuji Sumitomo
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Hiroko Kanda
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Akari Suzuki
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Yuta Kochi
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Kazuhiko Yamamoto
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Keishi Fujio
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  • For correspondence: kfujio-tky@umin.ac.jp
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The Journal of Rheumatology
Vol. 45, Issue 7
1 Jul 2018
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HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Jul 2018, 45 (7) 905-914; DOI: 10.3899/jrheum.170909

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HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Jul 2018, 45 (7) 905-914; DOI: 10.3899/jrheum.170909
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Keywords

RHEUMATOID ARTHRITIS
T LYMPHOCYTES
HLA ANTIGENS
CYTOKINES
NEXT-GENERATION SEQUENCING

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Keywords

  • rheumatoid arthritis
  • T LYMPHOCYTES
  • HLA ANTIGENS
  • cytokines
  • NEXT-GENERATION SEQUENCING

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