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Research ArticleRheumatoid Arthritis

HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis

Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto and Keishi Fujio
The Journal of Rheumatology July 2018, 45 (7) 905-914; DOI: https://doi.org/10.3899/jrheum.170909
Keiichi Sakurai
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
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Kazuyoshi Ishigaki
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Hirofumi Shoda
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Yasuo Nagafuchi
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Yumi Tsuchida
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Shuji Sumitomo
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Hiroko Kanda
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Akari Suzuki
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Yuta Kochi
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Kazuhiko Yamamoto
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Keishi Fujio
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  • For correspondence: kfujio-tky@umin.ac.jp
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Article Information

vol. 45 no. 7 905-914
DOI 
https://doi.org/10.3899/jrheum.170909
PubMed 
29657145

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication January 24, 2018
  • Published online July 1, 2018.

Article Versions

  • Latest version (April 15, 2018 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018

Author Information

  1. Keiichi Sakurai,
  2. Kazuyoshi Ishigaki,
  3. Hirofumi Shoda,
  4. Yasuo Nagafuchi,
  5. Yumi Tsuchida,
  6. Shuji Sumitomo,
  7. Hiroko Kanda,
  8. Akari Suzuki,
  9. Yuta Kochi,
  10. Kazuhiko Yamamoto and
  11. Keishi Fujio⇑
  1. From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
  2. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo.
  1. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky{at}umin.ac.jp

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The Journal of Rheumatology
Vol. 45, Issue 7
1 Jul 2018
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HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Jul 2018, 45 (7) 905-914; DOI: 10.3899/jrheum.170909

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HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Jul 2018, 45 (7) 905-914; DOI: 10.3899/jrheum.170909
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Keywords

RHEUMATOID ARTHRITIS
T LYMPHOCYTES
HLA ANTIGENS
CYTOKINES
NEXT-GENERATION SEQUENCING

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Keywords

  • rheumatoid arthritis
  • T LYMPHOCYTES
  • HLA ANTIGENS
  • cytokines
  • NEXT-GENERATION SEQUENCING

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