Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • 50th Volume Reprints
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • 50th Volume Reprints
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow Jrheum on BlueSky
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleSystemic Lupus Erythematosus

Repeat Testing of Antibodies and Complements in Systemic Lupus Erythematosus: When Is It Enough?

Thomas C. Raissi, Carly Hewson and Janet E. Pope
The Journal of Rheumatology June 2018, 45 (6) 827-834; DOI: https://doi.org/10.3899/jrheum.161365
Thomas C. Raissi
From the University of Western Ontario, Schulich School of Medicine and Dentistry, Department of Medicine; Division of Rheumatology, Department of Medicine, St. Joseph’s Health Care, London, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carly Hewson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janet E. Pope
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: janet.pope{at}sjhc.london.on.ca
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
PreviousNext
Loading

REFERENCES

  1. 1.↵
    1. Tsokos GC
    . Systemic lupus erythematosus. N Engl J Med 2011;365:2110–21.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Arbuckle MR,
    2. McClain MT,
    3. Rubertone MV,
    4. Scofield RH,
    5. Dennis GJ,
    6. James JA,
    7. et al.
    Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003;349:1526–33.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Lam GK,
    2. Petri M
    . Assessment of systemic lupus erythematosus. Clin Exp Rheumatol 2014;23 Suppl 39:S120–32.
    OpenUrl
  4. 4.↵
    1. Kavanaugh A,
    2. Tomar R,
    3. Reveille J,
    4. Solomon DH,
    5. Homburger HA
    . Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med 2000;124:71–81.
    OpenUrlPubMed
  5. 5.↵
    1. Isenberg DA,
    2. Manson JJ,
    3. Ehrenstein MR,
    4. Rahman A
    . Fifty years of anti-ds DNA antibodies: are we approaching journey’s end? Rheumatology 2007;46:1052–6.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Pan N,
    2. Amigues I,
    3. Lyman S,
    4. Duculan R,
    5. Aziz F,
    6. Crow MK,
    7. et al.
    A surge in anti-dsDNA titer predicts a severe lupus flare within six months. Lupus 2014;23:293–8.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Linnik MD,
    2. Hu JZ,
    3. Heilbrunn KR,
    4. Strand V,
    5. Hurley FL,
    6. Joh T
    . Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus. Arthritis Rheum 2005;52:1129–37.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. ter Borg EJ,
    2. Horst G,
    3. Hummel EJ,
    4. Limburg PC,
    5. Kallenberg CG
    . Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study. Arthritis Rheum 1990;33:634–43.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Cozzani E,
    2. Drosera M,
    3. Gasparini G,
    4. Parodi A
    . Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects. Autoimmune Dis 2014;2014:321359.
    OpenUrlPubMed
  10. 10.↵
    1. Ho A,
    2. Barr SG,
    3. Magder LS,
    4. Petri M
    . A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2350–7.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Giles BM,
    2. Boackle SA
    . Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus. Immunol Res 2013;55:10–21.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Swaak AJ,
    2. Groenwold J,
    3. Bronsveld W
    . Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus. Ann Rheum Dis 1986;45:359–66.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Hochberg MC
    . Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Tan EM,
    2. Cohen AS,
    3. Fries JF,
    4. Masi AT,
    5. McShane DJ,
    6. Rothfield NF,
    7. et al.
    The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271–7.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Petri M,
    2. Orbai AM,
    3. Alarcón GS,
    4. Gordon C,
    5. Merrill JT,
    6. Fortin PR,
    7. et al.
    Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677–86.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Gladman DD,
    2. Ibañez D,
    3. Urowitz MB
    . Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002;29:288–91.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Man A,
    2. Shojania K,
    3. Phoon C,
    4. Pal J,
    5. de Badyn MH,
    6. Pi D,
    7. et al.
    An evaluation of autoimmune antibody testing patterns in a Canadian health region and an evaluation of a laboratory algorithm aimed at reducing unnecessary testing. Clin Rheumatol 2013;32:601–8.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Bonaguri C,
    2. Melegari A,
    3. Ballabio A,
    4. Parmeggiani M,
    5. Russo A,
    6. Battistelli L,
    7. et al.
    Italian multicentre study for application of a diagnostic algorithm in autoantibody testing for autoimmune rheumatic disease: conclusive results. Autoimmun Rev 2011;11:1–5.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Solomon DH,
    2. Kavanaugh AJ,
    3. Schur PH;
    4. American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines
    . Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002;47:434–44.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Faria AC,
    2. Barcellos KS,
    3. Andrade LE
    . Longitudinal fluctuation of antibodies to extractable nuclear antigens in systemic lupus erythematosus. J Rheumatol 2005;32:1267–72.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Tench CM,
    2. Isenberg DA
    . The variation in anti-ENA characteristics between different ethnic populations with systemic lupus erythematosus over a 10-year period. Lupus 2000;9:374–6.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Praprotnik S,
    2. Bozic B,
    3. Kveder T,
    4. Rozman B
    . Fluctuation of anti-Ro/SS-A antibody levels in patients with systemic lupus erythematosus and Sjögren’s syndrome: a prospective study. Clin Exp Rheumatol 1999;17:63–8.
    OpenUrlPubMed
  23. 23.↵
    1. Chow SL,
    2. Carter Thorne J,
    3. Bell MJ,
    4. Ferrari R,
    5. Bagheri Z,
    6. Boyd T,
    7. et al;
    8. Canadian Rheumatology Association Choosing Wisely Committee
    . Choosing wisely: the Canadian Rheumatology Association’s list of 5 items physicians and patients should question. J Rheumatol 2015;42:682–9.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Center for Medicaid & Medicare Services
    . Clinical Laboratory Fee Schedule 16CLAB Revised for January 2016. [Internet. Accessed February 2, 2018.] Available from: www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/ClinicalLabFeeSched/Clinical-Laboratory-Fee-Schedule-Files.html
  25. 25.↵
    1. Agarwal S,
    2. Harper J,
    3. Kiely PD
    . Concentration of antibodies to extractable nuclear antigens and disease activity in systemic lupus erythematosus. Lupus 2009;18:407–12.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Lateef A,
    2. Petri M
    . Managing lupus patients during pregnancy. Best Pract Res Clin Rheumatol 2013;27:435–47.
    OpenUrlCrossRef
  27. 27.↵
    1. Blomberg S,
    2. Ronnblom L,
    3. Wallgren AC,
    4. Nilsson B,
    5. Karlsson-Parra A
    . Anti-SSA/Ro antibody determination by enzyme-linked immunosorbent assay as a supplement to standard immunofluorescence in antinuclear antibody screening. Scand J Immunol 2000;51:612–7.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 45, Issue 6
1 Jun 2018
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Repeat Testing of Antibodies and Complements in Systemic Lupus Erythematosus: When Is It Enough?
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Repeat Testing of Antibodies and Complements in Systemic Lupus Erythematosus: When Is It Enough?
Thomas C. Raissi, Carly Hewson, Janet E. Pope
The Journal of Rheumatology Jun 2018, 45 (6) 827-834; DOI: 10.3899/jrheum.161365

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Repeat Testing of Antibodies and Complements in Systemic Lupus Erythematosus: When Is It Enough?
Thomas C. Raissi, Carly Hewson, Janet E. Pope
The Journal of Rheumatology Jun 2018, 45 (6) 827-834; DOI: 10.3899/jrheum.161365
del.icio.us logo Twitter logo Facebook logo  logo Mendeley logo
  • Tweet Widget
  •  logo
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Keywords

SYSTEMIC LUPUS ERYTHEMATOSUS
EXTRACTABLE NUCLEAR ANTIGENS
COMPLEMENTS
ANTI-dsDNA
IMMUNOLOGIC TESTING
COSTS

Related Articles

Cited By...

More in this TOC Section

  • Differences in Self-Reported Medication Nonadherence and Its Drivers in Young Adults Versus Older Adults With Systemic Lupus Erythematosus
  • Performance of Risk Score Calculators in the Identification of Coronary Artery Calcification in Patients With Systemic Lupus Erythematosus
  • Perceived and Objective Physical Function in 2 United States Population-Based Cohorts of Adults With Systemic Lupus Erythematosus
Show more Systemic Lupus Erythematosus

Similar Articles

Keywords

  • systemic lupus erythematosus
  • EXTRACTABLE NUCLEAR ANTIGENS
  • COMPLEMENTS
  • ANTI-dsDNA
  • IMMUNOLOGIC TESTING
  • COSTS

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2025 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire