Article Figures & Data
Tables
- Table 1.
Baseline patient-reported outcomes of ABioPharm patients, comparing self-identified indigenous to non-indigenous participants. Reported as n (%) or mean (SD) as appropriate, and p value reported only for significantly different values between groups.
Indigenous, n = 90 Non-indigenous, n = 1400 p PtGA, 0–10 7.1 (2.2) 6.6 (2.2) 0.05 Pain, 0–10 7.6 (2.2) 6.7 (2.2) < 0.0001 Fatigue, 0–10 7.1 (2.4) 6.6 (2.6) Sleep, 0–10 7.2 (2.9) 6.0 (3.0) < 0.0001 HAQ, 0–3 1.7 (0.6) 1.6 (0.6) 0.002 Stiffness, min 120 (173) 93 (144) 0.0022 EQ-5D 0.3 (0.3) 0.4 (0.3) 0.001 SF-36 physical health, standardized 25.3 (9.2) 26.9 (9.0) 0.05 SF-36 mental health, standardized 40.1 (12.1) 45.3 (11.9) 0.0002 ABioPharm: Alberta Biologics Pharmacosurveillance Program; PtGA: patient’s global assessment; HAQ: Health Assessment Questionnaire; SF-36: Medical Outcomes Study Short Form-36.
- Table 2.
Adjusted* baseline patient-reported outcomes and rate of change (per 12 mos) during treatment with first biologic agent.
Adjusted Rate of Change for Indigenous Patients, Slope (95% CI) Adjusted Rate of Change for Non-indigenous Patients, Slope (95% CI) Difference in Rate of Change, Mean (95% CI) PtGA −0.19 (−0.26 to −0.11), p < 0.001 −0.25 (−0.27 to −0.22), p < 0.001 0.06 (−0.02 to 0.14), p = 0.125 Pain −0.14 (−0.22 to −0.07), p < 0.001 −0.23 (−0.25 to −0.21), p < 0.001 0.09 (0.01–0.16), p = 0.029 Fatigue −0.12 (−0.19 to −0.05), p < 0.001 −0.19 (−0.22 to −0.17), p < 0.001 0.07 (0–0.15), p = 0.065 Sleep −0.11 (−0.19 to −0.04), p = 0.004 −0.20 (−0.23 to −0.17), p < 0.001 0.08 (0.00–0.17), p = 0.043 HAQ −0.04 (−0.06 to −0.03), p < 0.001 −0.05 (−0.06 to −0.05), p < 0.001 0.01 (−0.01 to 0.03), p = 0.238 Stiffness −6.1 (−9.0 to −3.3), p < 0.001 −5.4 (−6.4 to −4.4), p < 0.001 −0.71 (−3.72 to 2.30), p = 0.643 EQ-5D 0.03 (0.02–0.03), p < 0.001 0.02 (0.02–0.03), p < 0.001 0.00 (−0.01 to 0.01), p = 0.476 SF-36 Physical Health (standardized) 0.53 (0.23–0.83), p < 0.001 0.88 (0.78–0.98), p < 0.001 −0.35 (−0.66 to −0.03), p = 0.03 SF-36 Mental Health (standardized) 0.40 (0.14–0.65), p = 0.002 0.56 (0.47–0.65), p < 0.001 −0.16 (−0.43 to 0.10), p = 0.232 ↵* Adjusted for baseline DAS28, age, sex, disease duration at index date, current smoking status, and baseline health assessment questionnaire (HAQ) score. PtGA: patient’s global assessment; SF-36: Medical Outcomes Study Short Form-36; DAS28: Disease Activity Score at 28 joints.
- Table 3.
Allied health and community services use, mean number of visits per patient over past 3 months, comparing self-identified indigenous to non-indigenous participants. Reported as mean (SD) unless indicated.
Inception Final Visit Indigenous, n = 90 Non-indigenous, n = 1400 p Indigenous, n = 79 Non-indigenous, n = 1288 p Allied health services Physiotherapy 0.4 (1.7) 0.5 (2.2) 0.88 0.1 (0.7) 0.2 (1.4) 0.25 Occupational therapy 0.1 (0.4) 0.1 (1.1) 0.88 0.1 (0.5) 0.0 (0.4) 0.58 Chiropractor 0.0 (0.4) 0.3 (1.5) 0.08 0.0 (0.2) 0.2 (1.2) 0.11 Acupuncture 0.1 (0.0) 0.2 (1.1) 0.53 0.0 (0.1) 0.1 (0.7) 0.35 Massage 0.2 (1.2) 0.3 (1.3) 0.18 0.0 (0.1) 0.3 (1.6) 0.01 Community services Any service used, % 8.1 3.2 0.03 7.7 3.3 0.05 Paid for services, % 9.8 9.4 0.85 6.4 8.2 0.83 Home help, hours/week 0.6 (2.5), median 0 (range 0–20) 0.3 (3.5), median 0 (range 0–12) 0.02 0.1 (0.7), median 0 (range 0–6) 0.3 (1.9), median 0 (range 0–40) 0.78 Childcare, hours/week 0.0 (0.0), median 0 (range 0–40) 0.1 (1.3), median 0 (range 0–40) 0.42 0.0 (0.0), median 0 (range 0–0) 0.0 (0.4), median 0 (range 0–10) 0.67 - Table 4.
Participation in activities of daily living, comparing self-identified indigenous to non-indigenous participants. Reported as mean (SD) unless indicated.
Inception Final Visit Indigenous, n = 90 Non-indigenous, n = 1400 p Indigenous, n = 79 Non-indigenous, n = 1288 p Participation in normal activities (in past month) Unable, % 70.9 66.2 0.41 50.0 36.9 0.03 No. days 8.0 (9.9) 6.0 (28.2) < 0.001 4.0 (7.0) 3.1 (7.1) 0.01 No. hours/day 4.8 (8.2) 3.8 (27.4) 0.01 3.5 (6.4) 2.2 (5.6) 0.01 Assistance required for normal activities (in past month) Required help, % 61.2 52.5 0.14 33.8 28.5 0.36 No. days 6.6 (9.7) 5.2 (28.2) < 0.01 3.6 (7.6) 2.6 (6.9) 0.09 No. hours/day 3.2 (5.6) 2.5 (27.2) < 0.01 1.1 (2.7) 1.0 (3.1) 0.29 Inception Final Visit Indigenous, n = 90 Non-indigenous, n = 1400 Indigenous, n = 79 Non-indigenous, n = 1288 Employed 44.3 46.4 41.3 43.2 Days unable to work due to RA over past 6 months, mean (SD) 6.9 (24.7) 3.7 (16.4) 1.6 (5.8) 1.9 (11.3) Proportion of cohort reporting a change in work hours over last 6 months due to RA 15.6 7.5 5.1 5.1 Unemployed 17.7 6.3 23.8 6.8 If unemployed, stopped work because of arthritis 64.4 51.0 81.8 47.9 Disabled 24.1 13.3 28.6 11.4 Housework 3.8 9.2 1.6 6.6 Student 3.8 1.9 0.0 1.0 Retired 6.3 22.9 4.8 31.0 RA: rheumatoid arthritis.
