Article Figures & Data
Figures
- Figure 1.
Comparison of DAS28 responders versus nonresponders (according to EULAR) at 3 months (V3, left side) and 6 months (V6, right side) depicted by box plots. Erosion subscore (upper half) and total RAMRIS (lower half) were significantly different between groups at 3 months. At 6 months no significant differences were found. DAS28: 28-joint count Disease Activity Score; EULAR: European League Against Rheumatism; RAMRIS: rheumatoid arthritis magnetic resonance imaging scoring system.
- Figure 2.
Comparison of DAS28 responders versus nonresponders (according to EULAR) at 3 months (V3, left side) and 6 months (V6, right side) depicted by box plots. RANKL was significantly different between groups at 6 months. DAS28: 28-joint count Disease Activity Score; EULAR: European League Against Rheumatism; RANKL: receptor activator of nuclear factor-κB ligand.
Tables
N = 28 Values Male 9 (32%) Female 19 (68%) Age average 56.8 yrs (min 39 yrs, max 74 yrs) Disease duration average 16.3 weeks (min 2 weeks, max 23 weeks) RF+ and/or anti-CCP antibody+ 28 (100%): average RF 215 IU/ml (min 24, max 2314 IU/ml); average anti-CCP antibodies 131 U/ml (min 5, max > 200 U/ml) CRP, baseline, mg/l average 9.6 (SD 9.3; min 3, max 37) CRP, V3 (3 mos), mg/l average 6.5 (SD 8.6; min 3, max 37) CRP, V6 (6 mos), mg/l average 3.6 (SD 2.5; min 1, max 12) DAS28 baseline average 4.7 (SD 0.85; min 3.3, max 6.3) DAS28 V3 (3 mos) average 3.5 (SD1.3; min 1.6, max 6.2) DAS28 V6 (6 mos) average 2.6 (SD 0.83; min 1.6, max 4.8) RAMRIS baseline average 29.25 (SD 12.5; min 10, max 59) RAMRIS V3 average 27.38 (SD 11.35; min 10, max 57) RAMRIS V6 average 27.61 (SD 10.5; min 9, max 52) Erosion subscore baseline 7.93 (SD 6.7; min 0, max 21) Erosion subscore V3 9.0 (SD 6.96; min 0, max 21) Erosion subscore V6 9.1 (SD 7.05; min 0, max 21) Erosions (radiograph), baseline 1/28 RF: rheumatoid factor: anti-CCP: anticyclic citrullinated peptide antibodies; CRP: C-reactive protein; DAS28: 28-joint count Disease Activity Score; RAMRIS: rheumatoid arthritis magnetic resonance imaging scoring system.
Y = response status (yes/no) M1 M2 M3 M4 M5 M6 Xi = Time (in days) x x x x x x RANKL x RAMRIS erosion subscore total x RAMRIS total score x x RAMRIS synovitis subscore MCP-2 x x DAS28 score at baseline x AIC 47.22 50.634 49.781 49.799 49.872 52.099 LR test vs M0 vs M0 vs M0 vs M0 vs M0 vs. M0 p 0.191 0.0576 0.03473 0.03511 0.04144 0.1435 Bold face indicates significant data. RANKL: receptor activator of nuclear factor-κB ligand; RAMRIS: rheumatoid arthritis magnetic resonance imaging scoring system; MCP-2: second metacarophalangeal joint; DAS28: 28-joint count Disease Activity Score; AIC: Akaike information criterion; LR: likelihood ratio.
Y = remission status (yes/no) M1 M2 M3 M4 M5 Xi = Time (in days) x x x x x RANKL x RAMRIS erosion subscore total x RAMRIS total score x RAMRIS synovitis subscore MCP-2 x DAS28 score at baseline x AIC 36.686 47.183 47.395 47.232 47.386 LR test vs M0 vs M0 vs M0 vs M0 vs M0 p 0.0038 0.6362 0.9109 0.6754 0.8855 Bold face indicates significant data. RANKL: receptor activator of nuclear factor-κB ligand; RAMRIS: rheumatoid arthritis magnetic resonance imaging scoring system; MCP-2: second metacarophalangeal joint; DAS28: 28-joint count Disease Activity Score; AIC: Akaike information criterion; LR: likelihood ratio.
