Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleGout

The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years

Mohanad M. Elfishawi, Nour Zleik, Zoran Kvrgic, Clement J. Michet Jr., Cynthia S. Crowson, Eric L. Matteson and Tim Bongartz
The Journal of Rheumatology April 2018, 45 (4) 574-579; DOI: https://doi.org/10.3899/jrheum.170806
Mohanad M. Elfishawi
From Department of Rheumatology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt; Division of Rheumatology, Mayo Clinic College of Medicine; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota; Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, New York; Division of Rheumatology, Augusta University, Atlanta, Georgia; Department of Emergency Medicine, Vanderbilt University, Nashville, Tennessee, USA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nour Zleik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zoran Kvrgic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Clement J. Michet Jr.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cynthia S. Crowson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Tim.Bongartz@Vanderbilt.edu crowson@mayo.edu
Eric L. Matteson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tim Bongartz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Tim.Bongartz@Vanderbilt.edu crowson@mayo.edu
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective. To examine the incidence of gout over the last 20 years and to evaluate possible changes in associated comorbid conditions.

Methods. The medical records were reviewed of all adults with a diagnosis of incident gout in Olmsted County, Minnesota, USA, during 2 time periods (January 1, 1989–December 31, 1992, and January 1, 2009–December 31, 2010). Incident cases had to fulfill at least 1 of 3 criteria: the American Rheumatism Association 1977 preliminary criteria for gout, the Rome criteria, or the New York criteria.

Results. A total of 158 patients with new-onset gout were identified during 1989–1992 and 271 patients during 2009–2010, yielding age- and sex-adjusted incidence rates of 66.6/100,000 (95% CI 55.9–77.4) in 1989–1992 and 136.7/100,000 (95% CI 120.4–153.1) in 2009–2010. The incidence rate ratio was 2.62 (95% CI 1.80–3.83). At the time of their first gout flare, patients diagnosed with gout in 2009–2010 had higher prevalence of comorbid conditions compared with 1989–1992, including hypertension (69% vs 54%), diabetes mellitus (25% vs 6%), renal disease (28% vs 11%), hyperlipidemia (61% vs 21%), and morbid obesity (body mass index ≥ 35 kg/m2; 29% vs 10%).

Conclusion. The incidence of gout has more than doubled over the recent 20 years. This increase together with the more frequent occurrence of comorbid conditions and cardiovascular risk factors represents a significant public health challenge.

Key Indexing Terms:
  • GOUT
  • INCIDENCE
  • EPIDEMIOLOGY
  • COMORBIDITY

Footnotes

  • This work was made possible using the resources of the Rochester Epidemiology Project, which is supported by the US National Institute on Aging of the National Institutes of Health (NIH) under award number R01AG034676 and Clinical and Translational Science Awards grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the NIH.

  • Accepted for publication October 18, 2017.
View Full Text
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 45, Issue 4
1 Apr 2018
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years
Mohanad M. Elfishawi, Nour Zleik, Zoran Kvrgic, Clement J. Michet, Cynthia S. Crowson, Eric L. Matteson, Tim Bongartz
The Journal of Rheumatology Apr 2018, 45 (4) 574-579; DOI: 10.3899/jrheum.170806

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years
Mohanad M. Elfishawi, Nour Zleik, Zoran Kvrgic, Clement J. Michet, Cynthia S. Crowson, Eric L. Matteson, Tim Bongartz
The Journal of Rheumatology Apr 2018, 45 (4) 574-579; DOI: 10.3899/jrheum.170806
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
  • eLetters

Keywords

GOUT
INCIDENCE
EPIDEMIOLOGY
COMORBIDITY

Related Articles

Cited By...

More in this TOC Section

  • The Burden of Gout and Its Attributable Risk Factors in the Middle East and North Africa Region, 1990 to 2019
  • Long-Term Follow-up of a Randomized Controlled Trial of Allopurinol Dose Escalation to Achieve Target Serum Urate in People With Gout
  • Dual-Energy Computed Tomography Has Additional Prognostic Value Over Clinical Measures in Gout Including Tophi: A Systematic Literature Review
Show more Gout

Similar Articles

Keywords

  • gout
  • incidence
  • epidemiology
  • comorbidity

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire