Abstract
Objective. To evaluate the longterm efficacy and safety of subcutaneous tocilizumab (TCZ-SC) every 2 weeks (q2w) over 2 years in patients with rheumatoid arthritis who have an inadequate response to disease-modifying antirheumatic drugs (DMARD).
Methods. Patients (n = 656) were randomized 2:1 to TCZ-SC 162 mg q2w or placebo-SC q2w plus DMARD. After a 24-week double-blind period, patients (n = 457) were rerandomized to open-label TCZ-SC q2w by means of prefilled syringe or autoinjector. Escape therapy with weekly TCZ-SC was available for patients with inadequate efficacy from Week 12. Maintenance of response and safety to 2 years was assessed. Analyses used nonresponder imputation.
Results. The American College of Rheumatology (ACR) 20 response after TCZ-SC was maintained beyond Week 24 and was > 70% at each timepoint. ACR50/70, 28-joint Disease Activity Score remission, and ≥ 0.30 decrease from baseline in the Health Assessment Questionnaire–Disability Index response rates were also maintained after Week 24 in the TCZ-SC arm (≥ 50%, > 25%,> 32% and > 56%, respectively). Following escape for inadequate efficacy, many patients achieved ACR20 at the end of the study, 35% after escape from TCZ-SC, and 63% from placebo. The rates of serious adverse events [(11.20/100 patient-years (PY)] including serious infections (3.25/100 PY) were stable through Week 96. No association between anti-TCZ antibody development and loss of efficacy or adverse events was observed.
Conclusion. Efficacy and safety of TCZ-SC q2w was maintained up to 2 years and remained comparable with previously published data for intravenous TCZ. Dose escalation to weekly TCZ-SC was associated with ACR responses in prior nonresponders and was well tolerated.
Tocilizumab (TCZ) is a recombinant humanized monoclonal antibody targeted against human interleukin 6 receptor-α, and subcutaneous TCZ (TCZ-SC) was developed as an alternative to intravenous TCZ (TCZ-IV). TCZ-IV has well-established efficacy and a manageable safety profile, both as monotherapy or in combination with disease-modifying antirheumatic drugs (DMARD), in patients with rheumatoid arthritis (RA)1,2,3,4. The safety and efficacy of TCZ-SC are comparable with TCZ-IV as monotherapy and with DMARD, and TCZ-SC has been approved for use globally5,6,7,8,9.
At 2 years, the phase III TCZ-SC trials SUMMACTA8 [weekly (qw) with DMARD)] and MUSASHI9 [every 2 weeks (q2w) as monotherapy] showed that TCZ-SC maintained efficacy and safety comparable to TCZ-IV. The phase III BREVACTA study evaluated the efficacy and safety of biweekly TCZ-SC in combination with DMARD in patients with moderate to severe RA and an inadequate response to DMARD6. TCZ-SC 162 mg q2w demonstrated significantly greater efficacy, including inhibiting joint damage, versus placebo (PBO)-SC at Week 24. TCZ-SC q2w was well tolerated and its safety profile was consistent with the TCZ-IV profile, except for increased injection-site reactions (ISR)6.
Our analysis evaluated the longterm efficacy and safety of TCZ-SC q2w up to Week 96. Data for patients who received TCZ qw following escalation from either TCZ-SC q2w or PBO q2w to Week 96 are included.
MATERIALS AND METHODS
Participants
Patients signed informed consent documents approved by an institutional review board or independent ethics committee. Our study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. Quorum Review IRB approved the study (25643/2) and approval was obtained for each study site (about 170 centers). Patient selection criteria were previously described6. All patients had an inadequate response to ≥ 1 DMARD, and 21% had an inadequate response to anti-tumor necrosis factor (anti-TNF) agents. Patients continued to receive ≥ 1 nonbiologic DMARD at the stable pre-entry dose.
Study design
BREVACTA (clinicaltrials.gov, identifier: NCT01232569) was a phase III, randomized, double-blind, 2-arm, 2-year PBO-controlled, parallel-arm multicenter trial with a 24-week double-blind period, followed by a 72-week open-label extension period (Supplementary Figure 1, available with the online version of this article). At baseline, patients were randomized 2:1 to receive TCZ-SC 162 mg q2w or PBO-SC q2w by prefilled syringe. At Week 24, patients were rerandomized 1:1 to receive TCZ-SC 162 mg q2w by prefilled syringe or autoinjector. Escape therapy with TCZ-SC qw was available from weeks 12 to 48 to patients with < 20% improvement in swollen joint count (SJC) and tender joint count (TJC) from baseline. After Week 48, patients could receive TCZ-SC 162 mg qw if there was ≤ 70% improvement from baseline in SJC and TJC.
Outcomes and assessments
Evaluations included the percentage of patients who achieved 20%, 50%, and 70% improvements in response per the American College of Rheumatology criteria (ACR20/50/70); remission based on the Disease Activity Score using 28 joints calculated with erythrocyte sedimentation rate (DAS28 < 2.6); and decreases in Health Assessment Questionnaire–Disability Index (HAQ-DI) scores of ≥ 0.30. Radiographic progression from baseline to weeks 24 and 48 was assessed using the modified total Sharp score analysis (mTSS)10 and performed by 2 primary readers, with an adjudicator involved for any discrepancies. Safety assessments included adverse events (AE), laboratory measurements, and immunogenicity11.
Statistical analysis
Data from the prefilled syringe and autoinjector devices were combined. The efficacy and laboratory analyses used the intention-to-treat (ITT) population: 1 group received TCZ-SC continuously (TCZ-SC arm), and 1 group received PBO to Week 24 and was then rerandomized to TCZ-SC (PBO–TCZ-SC arm). The nonresponder analysis included all patients who completed Week 24, were rerandomized, received ≥ 1 dose of rerandomized study treatment, and had a valid assessment at the timepoint analyzed. No formal statistical analyses were performed at Week 96. For completer analysis, the efficacy data were reported as observed in patients who completed the study, with no imputation of missing data. Radiographic data were evaluated at baseline, Week 24, and Week 48, with early withdrawal or escape therapy readings evaluated up to the Week 48 visit. Missing Week 48 data were imputed using linear extrapolation.
The safety population consisted of 3 groups: TCZ-SC q2w (safety events in the double-blind and open-label periods), PBO–TCZ-SC (events from TCZ-SC in the open-label period), and PBO (events in the double-blind period). All patients had ≥ 1 postdose assessment of safety. In the PBO–TCZ-SC arm, AE in patients who withdrew, died, or escaped in the first 24 weeks were not included. For patients who continuously received TCZ-SC in the double-blind and open-label periods, all events were included. The ITT pharmacokinetic population consisted of patients who provided ≥ 1 pharmacokinetic sample for TCZ and serum interleukin 6 receptor in the double-blind or open-label periods.
Efficacy and safety analyses for the escape population included all patients who received TCZ-SC qw. Only data from the time of escape were included in the escape patient analyses. Patients were rebaselined, and the last assessment prior to their first qw dose was considered the baseline. All analyses were exploratory.
RESULTS
Patient disposition and baseline characteristics
Of the 461 patients who completed Week 24 without escape therapy, 457 continued in this longterm extension study; 338 were rerandomized from blinded TCZ-SC to receive open-label TCZ-SC q2w, and 119 were rerandomized from blinded PBO to open-label TCZ-SC q2w (Figure 1). During the open-label period, 43 patients (12.7%) who initiated TCZ-SC and 11 (9.2%) who initiated PBO withdrew. The most common reasons for withdrawal were patient decision (1 patient withdrew because of pregnancy; n = 21) and AE (n = 19).
Of the 189 escape patients (TCZ-SC qw), 162 received escape therapy prior to Week 24. There were 14 patients who withdrew from the escape–TCZ-SC group and 17 from the escape-PBO group after Week 24; the most common reason was AE (6 patients/arm).
Patient demographics and clinical characteristics were balanced across the treatment groups (Supplementary Table 1, available with the online version of this article).
Efficacy
In nonresponder analyses, ACR20 responses in the TCZ-SC group were maintained from 78% at Week 24 to 72% at Week 96; in the PBO–TCZ-SC group, the ACR20 response increased from 56% at Week 24 to 81% at Week 36 and was sustained thereafter through Week 96 (Figures 2A and 2B). From weeks 24 to 96, DAS28 remission rates increased and the rates for a decrease in HAQ-DI scores of ≥ 0.30 were sustained, respectively, in the TCZ-SC group (DAS28: 33% and 45%; HAQ-DI: 59% and 57%; Figures 2C and 2D). A greater percentage of patients in the PBO–TCZ-SC group achieved DAS28 remission or a decrease in HAQ-DI score of ≥ 0.3 from weeks 24 to 96, respectively (DAS28: 4% and 42%; HAQ-DI: 47% and 57%; Supplementary Figure 2, available with the online version of this article). Similar efficacy results were observed by completer analysis (Supplementary Figures 2 and 3, available with the online version of this article).
Patients in the PBO–TCZ-SC group experienced more radiographic progression at Week 48 from baseline than patients in the TCZ-SC group (mean mTSS change: 1.48 vs 0.64; Figure 3A; cumulative distribution plot in Figure 3B). The mean annualized progression rate for mTSS decreased in both treatment arms through Week 48 and was 2-fold higher in the PBO–TCZ-SC arm than in the TCZ-SC arm (0.57 vs 0.29).
Efficacy by weight stratification
Evidence of efficacy, as measured by ACR20/50/70, was demonstrated across all weight groups (< 60 kg, 60 to < 100 kg, ≥ 100 kg) with both TCZ-SC and PBO–TCZ-SC arms through to Week 96. However, response rates were variable, and the analysis was limited by the small number of patients in some groups (Supplementary Figure 4, available with the online version of this article).
Pharmacokinetics
The mean TCZ concentration was stable in all patients from weeks 48 to 96 (Supplementary Figure 5, available with the online version of this article). In patients who received PBO up to Week 24, after rerandomization the mean pre-dose TCZ concentrations increased.
Safety
The safety profile of TCZ-SC q2w over 96 weeks was consistent with that in the double-blind period (Table 1; Supplementary Figure 6, available with the online version of this article). The rate of AE/100 PY for TCZ-SC q2w did not increase from weeks 24 to 96, and the rate of serious AE (SAE) was low and consistent over time (Supplementary Figure 6). The rate of withdrawals/100 PY because of AE for TCZ-SC q2w was 4.22, and 1.30 for the PBO to TCZ-SC q2w group (Supplementary Figure 6). For TCZ-SC q2w, infections were the most common AE and SAE (Table 1). The rate of serious infections/100 PY for TCZ-SC q2w was 3.25, and was 0.65 for the PBO to TCZ-SC q2w group. Rates of serious infections/100 PY did not increase with increasing exposure to treatment (Supplementary Figure 6). In the TCZ-SC group, 16 patients developed 20 serious infections: the most common were pneumonia, sepsis, lower respiratory tract, bacterial arthritis, osteomyelitis, and pulmonary tuberculosis (2 patients each). One patient in the PBO–TCZ-SC group experienced a serious infection (urinary tract). Opportunistic infections during the open-label period were reported in 2 patients (esophageal candidiasis and atypical pneumonia) in the TCZ-SC group; 1 patient had coccidioidomycosis during the double-blind period as previously reported (Supplementary Table 2, available with the online version of this article). No opportunistic infections were reported during the open-label period in the PBO–TCZ-SC group.
There were 6 malignancies that occurred over the 2-year study (Table 1), 3 of which were reported in 3 patients during the open-label period in the TCZ-SC group: rectal cancer, thyroid neoplasm, and ovarian cancer. One patient in the PBO–TCZ-SC group developed 2 malignancies: grade 2 squamous cell carcinoma and grade 3 non-Hodgkin lymphoma.
There were 9 deaths that occurred during the entire study, 5 of which occurred during the open-label period (Supplementary Table 3, available with the online version of this article). The rate of death in the TCZ-SC group during the double-blind and open-label periods was 1.14/100 PY (95% CI 0.46–2.34); in the PBO–TCZ-SC group, it was 0.65/100 PY (95% CI 0.02–3.61) during the open-label period only. No deaths occurred in the PBO-TCZ-SC group during the double-blind period. The most common causes of death over 96 weeks were cardiovascular events (myocardial infarction and angina, n = 4) and infections (sepsis and lower respiratory tract infection, n = 3). One patient who was hospitalized and treated with antibiotics for fever of unknown origin developed multiple organ failure and died. One death is described in the escape section.
The rates of hypersensitivity AE (defined as all AE except ISR) that occurred during or within 24 h of injection and that were not judged “unrelated” to treatment by the investigator, regardless of whether they were clinically consistent with hypersensitivity, were 5.20/100 PY in the TCZ-SC group and 2.59/100 PY in the PBO–TCZ-SC group (Table 1). One patient in the TCZ-SC group had a grade 1 hypersensitivity AE that led to treatment withdrawal; it manifested as hypotension, mild headache, and dizziness. One patient in the TCZ-SC group had a serious hypersensitivity event (Ludwig angina), but it was not clinically consistent with hypersensitivity. No patients in the PBO–TCZ-SC group reported hypersensitivity AE that led to study withdrawal or serious hypersensitivity AE. No cases of anaphylaxis, serious demyelinating events, serious gastrointestinal (GI) perforations (medically confirmed), or serious hepatic events occurred in either group.
Throughout the 96 weeks, 39 patients (8.9%) in the TCZ-SC group experienced 122 ISR and 3 patients (2.5%) in the PBO–TCZ-SC group experienced 3 ISR. Most ISR were grade 1, and none led to withdrawal. The most commonly reported ISR were injection-site erythema and pain.
Laboratory analysis
There were 18 (5.3%) and 11 patients (3.3%) in the TCZ-SC group who developed elevated [> 3× upper limit of normal (ULN)] alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, respectively. In the PBO–TCZ-SC group, elevated ALT and AST levels were identified in 8 (6.7%) and 4 patients (3.3%), respectively (Supplementary Table 4, available with the online version of this article). No patients met the Hy law criteria. Two patients in the TCZ-SC group withdrew because of abnormal ALT levels. Two patients in the PBO–TCZ-SC group and 12 patients in the TCZ-SC group had a dose modification because of abnormal ALT or AST levels.
Grade 3 or 4 neutropenia was identified in 17 patients (5.0%) in the TCZ-SC group and 7 (5.9%) in the PBO–TCZ-SC group. No patients in the PBO–TCZ-SC group and 4 patients who received TCZ-SC continuously withdrew because of neutropenia. No serious infections were associated with neutropenia. One patient had grade 3 thrombocytopenia. No serious bleeding events were associated with thrombocytopenia.
Patients in the PBO arm who initiated TCZ-SC at Week 24 developed shifts from baseline in lipid variables similar to those in patients who received TCZ-SC and were rerandomized at Week 24 (Supplementary Table 4, available with the online version of this article). Of the patients whose cholesterol was within normal limits at baseline, postbaseline shifts from ≤ 200 mg/dl to worse values ≥ 240 mg/dl were observed in 8.0% of patients. Similar results were observed for low-density lipoprotein cholesterol.
Immunogenicity
There were 9 patients in the TCZ-SC group and 1 patient in the PBO–TCZ-SC group who developed anti-TCZ antibodies postbaseline with both the confirmation and neutralizing assays. No patient who developed anti-TCZ antibodies had hypersensitivity events that led to study withdrawal, anaphylaxis, or ISR, or experienced loss of efficacy (defined as withdrawal owing to lack of efficacy and a pre-withdrawal ACR50 response or European League Against Rheumatism good response).
Safety subgroup analyses by weight
There was considerable variability in AE and SAE rates by weight (Supplementary Table 5, available with the online version of this article).
Efficacy in escape population
In nonresponder analyses, ACR responses in both the escape-PBO and escape–TCZ-SC groups increased, following escalation to TCZ-SC qw (Figures 4A and B). A total of 41% of patients in the escape-PBO group and 19% of patients in the escape–TCZ-SC group achieved DAS28 remission at Week 84 (Figure 4C; Supplementary Figure 7A, available with the online version of this article). Similar patterns were observed for other efficacy variables: DAS28 and HAQ-DI scores, and the percentage of patients who achieved a decrease in HAQ-DI ≥ 0.3 (Figure 4; Supplementary Figure 7). Completer analysis gave similar efficacy results (Supplementary Figures 7 and 8, available with the online version of this article).
Safety in escape population
The overall AE profile in patients who received escape therapy with TCZ-SC qw was comparable with that in patients who received TCZ-SC q2w continuously, and was similar between the escape-PBO and escape–TCZ-SC q2w groups (Table 1 and Table 2). There were 14 patients in the prior-PBO arm and 16 patients in the prior–TCZ-SC q2w arm who had 19 and 23 SAE, respectively; the most common were infections. A total of 7 patients in the escape-PBO group and 8 in the escape–TCZ-SC q2w group developed 7 and 12 serious infections, respectively; the most common were cellulitis (n = 6) and pneumonia (n = 3). One patient in the escape–TCZ-SC group had an opportunistic infection of grade 2 atypical pneumonia, which resulted in interruption of study treatment; the event resolved without sequelae. The rates of AE, SAE, infections, serious infectious events, and withdrawals because of AE were broadly comparable over time, with wide and overlapping CI between the escape populations, and did not increase with continued exposure to TCZ-SC qw (Supplementary Figure 9, available with the online version of this article).
In the escape-PBO group, 5 malignancies occurred in 4 patients (Table 2): basal cell and squamous cell carcinoma occurred in 1 patient and leiomyosarcoma, malignant melanoma, and pancreatic carcinoma occurred in 1 patient each. In the escape–TCZ-SC group, 2 malignancies occurred in 2 patients: anal squamous cell carcinoma and breast cancer.
One death resulting from upper GI hemorrhage occurred in a patient from the escape-PBO group (Supplementary Table 3). Five escape patients (2 in the prior TCZ-SC arm and 3 in the prior PBO arm) had a hypersensitivity event. One patient in the escape-PBO group had 2 hypersensitivity events that led to study withdrawal (reported as grade 3 headache and grade 2 malaise). No cases of anaphylaxis, serious hypersensitivity events, serious demyelinating events, serious GI perforations (medically confirmed), or serious hepatic events were reported. In the escape-PBO group, 15 ISR occurred in 5 patients; most were injection-site erythema (4.4%). One patient had a grade 3 ISR that led to dose modification from TCZ-SC qw to TCZ-SC q2w; the event resolved without sequelae. In the escape–TCZ-SC group, 15 ISR occurred in 6 patients. No ISR led to withdrawal.
Laboratory analysis of escape population
In the escape–TCZ-SC group, 2 patients (2.0%) developed elevated (> 3× ULN) ALT; none had similarly elevated AST. The respective values in the escape-PBO group were 7 (7.7%) and 5 (5.5%). No patients met the Hy law criteria. One patient in the escape-TCZ group discontinued treatment because of grade 3 AE of elevated ALT and AST levels. Dose modification because of ALT elevation occurred in 5 patients (5.1%) in the escape-TCZ group and in 7 (7.7%) in the escape-PBO group, and because of elevated AST in 5 (5.1%) and 4 patients (4.4%), respectively.
Neutropenia was reported in 8.2% of escape–TCZ-SC patients and in 12.1% of escape-PBO patients. Thrombocytopenia was reported in 3 patients (3.1%) in the escape-TCZ group and in 1 patient (1.1%) in the escape-PBO group. One patient (1.0%) in the escape–TCZ-SC group and 8 (8.8%) in the escape-PBO group had shifts from normal to elevated total cholesterol (≥ 240 mg/dl). The incidence of shifts from normal (< 150 mg/dl) to abnormal (≥ 150 to < 500 mg/dl) triglycerides was slightly higher in the escape-PBO group [22 patients (24.2%)] than in the escape–TCZ-SC group [17 patients (17.3%)].
Immunogenicity in escape population
Three patients (3.3%) in the escape-PBO group and 1 patient (1.0%) in the escape–TCZ-SC q2w group developed anti-TCZ antibodies11. Two patients (2.2%) in the escape-PBO group and 1 patient (1.0%) in the escape–TCZ-SC q2w group had a positive neutralizing antibody assay after the initiation of escape therapy. No patients who developed anti-TCZ antibodies had hypersensitivity events that led to study withdrawal, anaphylaxis, ISR, or loss of efficacy.
DISCUSSION
The BREVACTA study demonstrated that the efficacy and safety of TCZ-SC q2w were maintained over 96 weeks. Patients who were rerandomized from PBO to TCZ-SC (PBO–TCZ-SC group) had continued improvements in efficacy after Week 24, and by Week 36 the results were comparable with those in patients who received TCZ-SC continuously from baseline and sustained through 2 years. Patients who escaped from TCZ-SC q2w to TCZ-SC qw also had clinical improvement, but did not achieve as high a percentage of ACR responses. TCZ-SC q2w and qw were well tolerated, and the rate of AE and frequency of laboratory abnormalities did not increase with continued exposure. No new safety signals were observed.
With the exception of ISR, the safety profile of the TCZ-SC arm in our study was consistent with the known safety profile of TCZ-IV and was comparable with that observed in the longterm extension of the TCZ-SC trials8,9. The death rates were similar between the TCZ-SC and PBO–TCZ-SC groups, with wide and overlapping CI (1.14/100 PY, 95% CI 0.46–2.34 and 0.65/100 PY, 95% CI 0.02–3.61). In the 96-week SUMMACTA study, the death rate/100 PY for patients receiving TCZ-SC 162 mg qw was 0.39 (95% CI 0.11–1.01), and was 0.49 (95% CI, 0.13–1.25) for patients receiving TCZ-IV 8 mg/kg every 4 weeks8. In a pooled analysis of TCZ-IV trials, the death rate for TCZ 8 mg/kg was 0.75/100 PY and for the all-exposure TCZ population, it was 0.45/100 PY12.
There was no intention to directly compare the TCZ-SC arm with the PBO–TCZ-SC arm; the data are presented for completeness. In the PBO–TCZ-SC arm, AE in patients who withdrew, died, or escaped in the first 24 weeks were not included, which makes it appear that this arm has fewer safety events. For patients who continuously received TCZ-SC in the double-blind and open-label periods, all events were included. Therefore, the event rates in the study arms contain data from different periods of the study and cannot be directly compared.
The percentage of patients with anti-TCZ antibodies remained low, comparable across the treatment arms and similar to those in other TCZ-SC studies8,9. No correlation between antibody development, hypersensitivity reactions, or loss of efficacy was observed.
Efficacy was similar between the TCZ-SC and PBO–TCZ-SC arms among patients who weighed < 60 kg, and among patients who weighed 60 to < 100 kg. ACR response rates in the TCZ-SC group were lower in patients who weighed ≥ 100 kg at baseline than in the other weight subgroups. This finding should be interpreted cautiously because of the small number of patients who weighed ≥ 100 kg; it is consistent with observations from Week 246. A similar trend was reported in TCZ-IV studies5, and in other studies, obese patients had lower responses to anti-TNF agents13.
Efficacy responses of patients who escaped to TCZ-SC qw from PBO were comparable with those in the TCZ-SC q2w arm. Patients who escaped from TCZ-SC q2w to TCZ-SC qw also had improvements in ACR responses and DAS28 remission when receiving TCZ-SC qw. The lower but still improved response suggests that some patients who did not respond or only partially responded to TCZ-SC q2w may benefit from more frequent dosing.
In the escape population, AE remained consistent with the known safety profile of TCZ, and did not increase. The most frequent AE following escape were similar to the main population and included infections and infestations, GI disorders, and investigations. Although the rates of SAE, withdrawals for AE, and infections were slightly higher in escape patients than those who received TCZ-SC q2w continuously, the rates were similar to those in the PBO arm during the double-blind period6, and the CI overlap.
TCZ-SC q2w demonstrated longterm efficacy, including sustained ACR responses, over 96 weeks. The safety profile of TCZ-SC at 96 weeks was comparable with that at 24 weeks. Improvement in efficacy was seen in some patients who did not initially respond to TCZ-SC q2w and who then received TCZ-SC qw.
ONLINE SUPPLEMENT
Supplementary material accompanies the online version of this article.
Acknowledgment
We thank all the investigators and patients who participated in the study, and all members of the BREVACTA (NA25220) study team. Support for third-party writing assistance for this manuscript, furnished by Denise Kenski, PhD, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd.
Footnotes
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This study was funded by Genentech, a member of the Roche Group, and Hoffmann-La Roche. Genentech and Hoffmann-La Roche sponsored the study and participated in the design of the study, as well as in the collection, analysis, and interpretation of the data. A. Kivitz received consulting fees and speakers bureau fees from Genentech. E. Olech received research grants and consulting fees from Genentech.
- Accepted for publication September 19, 2017.
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