Article Figures & Data
Figures
- Figure 1.
Representative examples of each grade of MRI synovitis score of the metacarpophalangeal joints. Coronal contrast-enhanced spoiled 3-D gradient-echo MRI with multiplanar reconstruction obtained from patients with JIA included in the present study. Synovitis in the joints highlighted by the crosshairs is graded 0–3 (A, absent; B, mild; C, moderate; D, severe) as estimated by thirds of the presumed maximum volume of enhancing tissue. MRI: magnetic resonance imaging; JIA: juvenile idiopathic arthritis.
- Figure 2.
Bland-Altman plots of the original (A) and extended (B) RAMRIS. Shown are the average score and difference between 2 observers for all subjects, according to the most discordant observer pair. Horizontal lines indicate mean differences (solid line) and 95% limits of agreement (dashed lines). Points were slightly dispersed to avoid overplotting. Note the different axis scales in the 2 panels. RAMRIS: Rheumatoid Arthritis Magnetic Resonance Imaging Score.
Tables
Sequence TR, ms TE, ms Slice Thickness/gap, mm NSA Voxel Size, mm Matrix TA Coronal TSE T1–3-D 600 10 1/0 2 0.8 × 0.8 × 0.8 176 × 175 5 min Coronal TSE T2 fat sat 2000 70 3/0 4 0.6 × 0.6 × 3 272 × 217 2 min 40 s Coronal T1 3-D GRE fat sat post CM, Gd-DTPA: 0.2 ml/kg 40 7 0.7/0 1 1 × 1 × 1 304 × 272 4 min MRI: magnetic resonance imaging; GRE: gradient echo; NSA: no. sample averages; TA: acquisition time; TE: echo time; TR: repetition time; TSE: turbo spin echo; CM: contrast medium; Gd-DTPA: gadolinium DTPA; fat sat: fat-saturated.
- Table 2.
Baseline patient characteristics. Values are the n (%) unless otherwise indicated.
Characteristics N = 70 Female 55 (79) JIA subtype Persistent oligoarthritis 6 (9) Extended oligoarthritis 17 (24) Polyarticular arthritis, RF-positive 7 (10) Polyarticular arthritis, RF-negative 19 (27) Systemic arthritis 21 (30) Disease duration, yrs, median (IQR) 4.0 (1.1–6.4) PGA, median (IQR) 7.3 (4.3–8.9) JADAS-71, median (IQR) 18.6 (11.5–40.9) IQR: interquartile range; JADAS: Juvenile Arthritis Disease Activity Score; JIA: juvenile idiopathic arthritis; PGA: physician’s global assessment; RF: rheumatoid factor.
Joint Persistent Oligoarthritis Extended Oligoarthritis Frequency Polyarticular Systemic Overall Radioulnar joint 4 (67) 14 (82) 22 (85) 17 (81) 57 (81) Radiocarpal joint 6 (100) 16 (94) 24 (92) 19 (90) 65 (93) Combined MC and CM joints 6 (100) 17 (100) 25 (96) 18 (86) 66 (94) MCP I joint 3 (50) 11 (65) 20 (76) 14 (67) 48 (69) MCP II joint 2 (33) 11 (65) 23 (88) 9 (43) 45 (64) MCP III joint 2 (33) 11 (65) 21 (81) 10 (48) 44 (63) MCP IV joint 2 (33) 9 (53) 21 (81) 11 (52) 43 (61) MCP V joint 3 (50) 10 (59) 21 (81) 11 (52) 45 (64) Any MCP joint 3 (50) 13 (76) 25 (96) 16 (76) 57 (81) Overall 6 17 26 21 70 (100) ↵1 Average score of all readers > 0. Values are the n (% within subtypes). CM: carpometacarpal; MC: midcarpal; MCP: metacarpophalangeal; MRI: magnetic resonance imaging.
ICC (95% CI) Score All Readers Together Less Experienced Readers Significance Wrist component of RAMRIS 0.77 (0.68–0.84) 0.82 (0.73–0.88) F (69,123.9) = 0.75, p = 0.90 Extended score 0.86 (0.80–0.91) 0.86 (0.78–0.91) F (69,119.4) = 1.02, p = 0.45 Significance F (69,119.4) = 1.80, p = 0.002 F (69, 69.9) = 1.31, p = 0.13 Weighted κ Joint Less Experienced Readers Experienced and First Less Experienced Reader Experienced and Second Less Experienced Reader Radioulnar joint 0.73 0.75 0.64 Radiocarpal joint 0.73 0.75 0.59 Combined CM and MC joints 0.73 0.72 0.68 MCP I joint 0.82 0.87 0.86 MCP II joint 0.83 0.85 0.82 MCP III joint 0.80 0.86 0.74 MCP IV joint 0.84 0.84 0.85 MCP V joint 0.82 0.81 0.76 The ICC was compared using the F test. CM: carpometacarpal; ICC: intraclass correlation coefficient; MC: midcarpal; MCP: metacarpophalangeal; RAMRIS: rheumatoid Arthritis magnetic resonance imaging scoring method.
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