Article Figures & Data
Tables
- Table 1.
No. patients (%) with different SSc subset and organ involvement at different times during the followup.
T0 T1 T2 T3 T4 T5 p* lcSSc 21 (91) 21 (91) 18 (78) 17 (74) 15 (65) 15 (65) 0.0004 dcSSc 2 (9) 2 (9) 5 (22) 6 (26) 8 (35) 8 (35) 0.0004 New DU 9 (39) 5 (22) 8 (35) 8 (35) 8 (35) 11 (48) ns ED 17 (74) 19 (83) 20 (87) 21 (91) 21 (91) 21 (91) 0.014 ILD 11 (48) 15 (65) 18 (78) 18 (78) 22 (96) 22 (96) < 0.0001 Kidney 2 (9) 2 (9) 4 (17) 4 (17) 5 (22) 5 (22) 0.019 PAH 0 (0) 0 (0) 0 (0) 1 (4) 2 (9) 2 (9) ns Heart 0 (0) 0 (0) 1 (4) 2 (9) 3 (13) 3 (13) 0.044 ↵T0 = baseline, T1 = 1 year, T2 = 2 yrs, T3 = 3 yrs, T4 = 4 yrs, T5 = 5 yrs. p*: statistical significance (Friedman test). SSc: systemic sclerosis; lcSSc: limited cutaneous SSc; dcSSc: diffuse cutaneous SSc; DU: digital ulcers; ED: esophageal dysmotility; ILD: interstitial lung disease; PAH: pulmonary arterial hypertension (diagnosed by right-heart cardiac catheterization); ns: not statistically significant.
- Table 2.
Mean ± SD of clinical variables at different times during the 5-year followup and statistical analysis between single times.
T0 T1 T2 T3 T4 T5 p* CN 5.40 ± 0.99 4.95 ± 1.13 4.68 ± 1.17 4.40 ± 1.26 4.32 ± 1.24 4.23 ± 1.21 < 0.0001 MES 6.00 ± 1.21 6.30 ± 1.40 6.52 ± 1.12 6.74 ± 1.18 6.57 ± 1.31 6.65 ± 1.27 0.01 FVC 115.26 ± 25.01 112.00 ± 25.35 108.78 ± 26.86 104.91 ± 23.46 103.91 ± 23.20 103.04 ± 23.27 0.0001 DLCO/VA 83.26 ± 13.30 80.30 ± 14.79 74.96 ± 16.81 72.70 ± 17.80 70.48 ± 17.77 71.17 ± 14.21 < 0.0001 RI 0.66 ± 0.07 0.66 ± 0.06 0.68 ± 0.07 0.70 ± 0.07 0.70 ± 0.07 0.72 ± 0.07 < 0.0001 Total DU 0.70 ± 0.97 1.00 ± 1.45 1.48 ± 1.97 2.00 ± 2.61 2.61 ± 3.20 3.30 ± 3.71 < 0.0001 sPAP 32.00 ± 6.56 32.87 ± 6.31 33.61 ± 7.38 33.39 ± 7.99 34.78 ± 7.71 35.35 ± 7.51 0.1037 mRSS 11.55 ± 7.12 11.92 ± 7.15 12.5 ± 7.01 13.21 ± 7.24 14.57 ± 7.38 15.48 ± 7.57 0.0024 ↵T0 = baseline, T1 = 1 year, T2 = 2 yrs, T3 = 3 yrs, T4 = 4 yrs, T5 = 5 yrs. p*: statistical significance (Friedman test). CN: nailfold capillary no./mm (distal row); MES: microangiopathy evolution score (range 0–9); FVC: forced vital capacity (% predicted, normal values > 80); DLCO/VA: DLCO per unit of lung volume (% predicted, normal values > 75); RI: renal arterial resistive index (normal values < 0.70); DU: digital ulcers; sPAP: echo-estimated systolic pulmonary arterial pressure (limit for cardiac catheterization > 40 mmHg); mRSS: modified Rodnan skin score; ns: not statistically significant.
