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Research ArticleOMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise

Daniel Glinatsi, Paul Bird, Frédérique Gandjbakhch, Espen A. Haavardsholm, Charles G. Peterfy, Edward M. Vital, Paul Emery, Philip G. Conaghan and Mikkel Østergaard
The Journal of Rheumatology November 2017, 44 (11) 1688-1693; DOI: https://doi.org/10.3899/jrheum.161097
Daniel Glinatsi
From the Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit; Leeds Teaching Hospitals National Health Service (NHS) Trust, Leeds, UK; University of New South Wales (NSW), Sydney, Australia; Hôpital Pitié-Salpétrière, APHP, Université Paris VI, Paris, France; Diakonhjemmet Hospital, Oslo, Norway; Spire Sciences Inc., Boca Raton, Florida, USA.
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  • For correspondence: daniel.glinatsi@gmail.com
Paul Bird
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Frédérique Gandjbakhch
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Espen A. Haavardsholm
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Charles G. Peterfy
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Edward M. Vital
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Paul Emery
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Philip G. Conaghan
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Mikkel Østergaard
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Abstract

Objective. To develop and validate a magnetic resonance imaging (MRI) tenosynovitis (TS) score for tendons at the wrist and metacarpophalangeal (MCP) joint levels in patients with rheumatoid arthritis (RA).

Methods. Axial T1-weighted precontrast and postcontrast fat-saturated MR image sets of the hands of 43 patients with RA initiating rituximab therapy were obtained at baseline and after 14, 26, 38, or 52 weeks. The MR images were scored twice by 4 readers. Nine tendon compartments of the wrist and 4 flexor tendon compartments at the MCP joints were assessed. Tenosynovitis was scored as follows: 0: No; 1: < 1.5 mm; 2: ≥ 1.5 mm but < 3 mm; 3: ≥ 3 mm peritendinous effusion and/or postcontrast enhancement. Intrareader and interreader intraclass correlation coefficients (ICC), smallest detectable change (SDC), percentage of exact and close agreement (PEA/PCA), and standardized response mean (SRM) were calculated.

Results. Intrareader and interreader ICC for status and change scores were very good (≥ 0.80) for total scores for all readers. Intrareader SDC was ≤ 3.0 and interreader SDC was < 2.0. The overall PEA/PCA intrareader and interreader agreements for change scores in all tendons were 73.8%/97.6% and 47.9%/85.0%, respectively. Average SRM was moderate for total scores and 60.5% of the patients had a tenosynovitis change score ≥ SDC.

Conclusion. The TS score showed high intrareader and interreader agreement for wrist and finger tendons, with moderate responsiveness, and the majority of the patients showed a change above the SDC. This scoring system may be included as a component of the RAMRIS.

Key Indexing Terms:
  • MAGNETIC RESONANCE IMAGING
  • TENOSYNOVITIS
  • RHEUMATOID ARTHRITIS
  • OMERACT

Tenosynovitis (TS) in the hand of patients with rheumatoid arthritis (RA) is a frequent and early occurring inflammatory feature that can cause tendon rupture and may be associated with subsequent bone erosion1,2,3,4,5. Magnetic resonance imaging (MRI) provides excellent visualization of bone and soft tissues in the hand, including TS.

The Outcome Measures in Rheumatology (OMERACT) MRI in Arthritis Working Group developed an RA MRI score (RAMRIS) for synovitis, osteitis, bone erosion, and recently, for joint space narrowing6,7. Adding TS to the RAMRIS may provide improved power to study and monitor the disease course of RA.

Haavardsholm, et al designed a TS score for the wrist that demonstrated good reliability and responsiveness8,9. In addition, the Working Group has suggested and validated a TS score for the fingers as part of the psoriatic arthritis MRI score (PsAMRIS)10,11,12. However, none of these scores covered the tendons at both wrist and metacarpophalangeal (MCP) joint level.

Our aim was to develop and validate an RA TS score for tendons at wrist and MCP joint levels. Here we present previously unpublished results that demonstrate the reliability of this novel score, enabling it to be included in the internationally renowned RAMRIS.

MATERIALS AND METHODS

Development of scoring system

In accordance with the processes in the OMERACT Handbook for technical tool development, previous MRI TS scores were identified through a thorough review of the literature by a fellow of the Working Group, which included rheumatologists, radiologists, methodologists, and industry representatives from 3 continents. The TS scores suggested by Haavardsholm, et al and the PsAMRIS appeared most thoroughly assessed methodologically and were tested in a pilot phase where the 2 TS scores were assessed at wrist and MCP joints by 2 readers at 2 timepoints8,9. The methodology by Haavardsholm, et al seemed more applicable to the wrist area and was therefore chosen for subsequent intrareader and interreader agreement analyses in a pre-exercise with 80 hands at 2 timepoints (baseline/1-year followup), in which the exact thickness of TS was also measured. The results were presented and discussed at a subsequent meeting of the Working Group, and modifications were implemented based on tendon sheath thickness distributions (Supplementary Figure 1, available with the online version of this article). The group then proceeded to perform the multireader exercise below.

Image selection

MR image sets were selected from a study13 in which patients with active RA (disease activity score > 3.2, rheumatoid factor-and/or anticyclic citrullinated peptide–positive, ≥ 1 previous disease-modifying antirheumatic drug) were treated with 2–3 doses of 1000 mg rituximab at baseline. MRI of the dominant hand was performed on a Siemens 1.5 Tesla MRI unit using a dedicated hand coil. Axial T1-weighted fat-saturated precontrast and postcontrast gradient echo MR image sets (slice thickness 0.45 mm, repetition time 30 ms, echo time 6.8 ms, field of view 150 mm) were obtained at baseline (n = 43) and after 14 (n = 5), 26 (n = 8), 38 (n = 15), or 52 (n = 15) weeks.

Scoring of images

Four readers (DG, FG, MØ, PB) with previous experience in MRI-assessment of TS participated in the exercise. The readers performed a calibration session the evening before the exercise. Forty-three paired MR image sets were blinded for patient data but not for chronology14, and were read twice on identical 23-inch screens over 2 days with reanonymizing and rerandomizing between the 2 reads.

Reader rules and scoring system

At the wrist, 6 extensor tendon compartments and 3 flexor tendon compartments were assessed between the radioulnar joint and the hook of hamate. At the level of the second to the fifth MCP joints, flexor tendons were assessed in an area from 1 cm proximal to 1 cm distal to each joint (Figure 1A).

Figure 1.
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Figure 1.

Scoring sheet for the TS score. At the wrist, 6 extensor tendon compartments and 3 flexor tendon compartments are assessed, and at the level of the second to the fifth metacarpophalangeal (MCP) joints, the flexor tendons are assessed. The range of the scores is 0–27, 0–12, and 0–39 for the tendons at the wrist, MCP joints, and total score, respectively (A). Measuring the common tendon sheath perpendicularly from an individual tendon (B) will result in overestimation of the thickness of the tendon sheath. Therefore, the tendons within a common tendon sheath are assessed as 1 unit (C), illustrated by the dashed lines. The enhancing tendon sheath is measured perpendicularly to the unit at the thickest point. FCR: flexor carpi radialis; FPL: flexor pollicis longus.

TS was defined as peritendinous effusion and/or postcontrast enhancement of the tendon sheath seen on axial sequences over ≥ 3 consecutive slices. The maximum width of the effusion and/or enhancing tendon sheath was measured perpendicularly to the tendon, and the TS score was graded as follows: 0: No; 1: < 1.5 mm; 2: ≥ 1.5 mm but < 3 mm; 3: ≥ 3 mm peritendinous effusion and/or postcontrast enhancement (Figure 1A). Tendon sheaths of crossing tendons were measured proximally to the crossing point, and tendon bundles within a common tendon sheath were assessed as 1 unit (Figure 1B–C). Supplementary Figure 2 (available with the online version of this article) shows examples of TS.

Statistical analysis

Descriptive statistics and the Wilcoxon signed-rank test were used to assess changes in score over time.

Intrareader and interreader agreement were assessed using single and average measure intraclass correlation coefficient (smICC/avmICC), respectively. The smallest detectable change (SDC) was calculated for intrareader and interreader change scores15 and was also expressed as the percentage of maximum observed change (%MOC). The percentage of exact agreement (PEA, scores equal) and the percentages of close agreement (PCA, scores ≤ 1 different) between the 2 reads and the 4 readers were calculated for intrareader and interreader agreement, respectively.

Responsiveness was assessed by the standardized response mean (SRM). Ability to show change was also assessed by the percentage of patients with change score ≥ SDC.

RESULTS

Baseline and followup characteristics of the patients are presented in Supplementary Table 1 (available with the online version of this article). Median (range) change in total TS score was −1.0 (−1.0 to −2.5; p < 0.01).

Intrareader smICC for baseline scores were very good for all measures in all readers, except for MCP scores in 1 reader (smICC 0.79). Intrareader smICC for change scores were good to very good for all measures. All readers demonstrated very good intrareader smICC for total scores. Baseline/change interreader avmICC were > 0.90 (i.e., very good) for all measures. Median (range) intrareader SDC was 2.8 (2.1–3.0) for total scores. Interreader SDC for scores averaged over 4 readers were < 2.0 for wrist, MCP (< 1.0), and total scores. The percentage of patients with a total change score ≥ SDC was 39.5% to 54.7% for intrareader SDC. For interreader SDC, this percentage was 60.5%. The %MOC was below 20% for intrareader and interreader total scores (Table 1).

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Table 1.

Intrareader and interreader agreement of the TS score.

The overall PEA/PCA intrareader and interreader agreements for change scores in all tendons were 73.8%/97.6% and 47.9%/85.0%, respectively (Table 1). PEA/PCA for individual tendons are presented in Supplementary Table 2 (available with the online version of this article). The inter-reader PEA/PCA for pairs of 2 readers were 72.4%/99.6% (baseline) and 73.3%/98.8% (change) for the best matched pair and 64.3%/98.3% (baseline) and 67.5%/97.0% (change) for the average pair when all tendons were considered.

The average SRM for total scores was moderate (Table 2). Overall, there were no differences in ICC, %MOC, PEA/PCA, and SRM between tendon sheaths at wrist versus MCP joint levels.

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Table 2.

Responsiveness of the TS score.

DISCUSSION

This longitudinal multireader exercise of patients with active RA showed that the TS score had high intrareader and inter-reader agreement and moderate responsiveness. The results were similar at wrist and MCP joint level.

Intrareader and interreader ICC were very good, both for total baseline and change scores, indicating that the TS score is reliable and can monitor change over time.

The average intrareader PEA was high and the PCA was close to 100%. Interreader PEA was acceptable considering the increased difficulty of 4 assessors needing to reach exact agreement, as compared to 2 assessors. Because most clinical trials have 2 assessors, we also analyzed the PEA/PCA for paired readers, and found the average percentages close to the intrareader agreements and the percentages of the best paired assessors in line with the intrareader agreements.

The interreader SDC was ≤ 2.0 and the %MOC < 11%. Although the average SRM was only 0.50 (moderate), > 60% of the patients showed a change ≥ SDC. Variable treatment regimens (related to different timing of infusions) and different timing of followup MRI may have affected the responsiveness but would not be expected to alter the intrareader and interreader agreement. Future studies should assess the responsiveness in early RA cohorts and in placebo-controlled studies, where responsiveness can be compared between groups.

This TS score was developed as a modification from the score by Haavardsholm, et al after assessing this and the PsAMRIS TS score in a pilot phase8,9,10,11. A key modification of the methodology by Haavardsholm, et al was to narrow the intervals of tendon sheath thickness within each increment to potentially increase the ability to detect change. As proven by this exercise, the reliability of the current TS score remained high. The responsiveness was not increased compared to the results reported by Haavardsholm, et al9, but because therapies in the 2 cohorts were different, the results are not fully comparable. Other advances, compared to the score by Haavardsholm, et al, included clarifications on how to score tendon sheaths of crossing tendons and common tendon sheaths of tendon bundles (Figure 1B–C).

Other MRI TS scores have previously been used. Several have not assessed reliability and responsiveness1,16 or have scored TS qualitatively as absent/present2,4,17,18,19,20,21,22. Regarding the monitoring of change, qualitative scores may have less power to detect changes in TS. Semiquantitative TS scores have been suggested by McQueen, et al23 and Schirmer, et al24, but did not assess the performance in longitudinal settings nor the intrareader and interreader agreement. Lisbona, et al25 suggested a TS score for the hand (based on incomplete and complete halos of enhancing tendon sheath) that showed high intrareader and interreader ICC, but small SRM.

This TS score was developed as a potential addendum to the existing RAMRIS6,26. Therefore, we strived to design the score so that it covered the tendons at the joint regions included in the RAMRIS core set. Because TS is scored on the same MRI sequences and projections as synovitis, these pathologies may be scored simultaneously and therefore the addition of TS score will add only a small amount of time to assessing a hand when using the RAMRIS method. Based on this and the reliability and responsiveness data, we conclude that this TS score fulfills the OMERACT filter criteria concerning truth, discrimination, and feasibility27 and may be included as a component of the RAMRIS for assessing TS of the hand in RA clinical trials.

ONLINE SUPPLEMENT

Supplementary material accompanies the online version of this article.

Acknowledgment

We thank illustrator Axel Norén for help with Figure 1, and the Danish Rheumatism Association.

Footnotes

  • Supported by the Danish Rheumatism Association. The clinical trial from which these data were acquired was supported by a research grant and study drug from Roche. The research is supported by the NIHR Leeds Musculoskeletal Biomedical Research Unit. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the UK Department of Health. Dr. Gandjbakhch has received consultation fees from Pfizer, AbbVie, Roche, and Janssen, and research support and grants from Pfizer and Roche. Dr. Haavardsholm has received consultation fees from Pfizer and MSD, and research support and grants from AbbVie, UCB, MSD, Pfizer, and Roche. Dr. Peterfy is a shareholder in Spire Sciences Inc. E.M. Vital has received research support and grants from Roche and AstraZeneca. P.G. Conaghan has been a consultant or on the speakers’ bureau for Abbvie, Lilly, Novartis, Pfizer, and Roche, and has received a research grant from BMS. Dr. Østergaard has received consultation fees from Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Centocor, GSK, Hospira, Janssen, Merck, Mundipharma, Novartis, Novo, Orion, Pfizer, Regeneron, Schering-Plough, Roche, Takeda, UCB, and Wyeth, and has received research support and grants from Abbvie, BMS, Janssen, and Merck.

  • Accepted for publication March 23, 2017.

REFERENCES

  1. 1.↵
    1. Boutry N,
    2. Hachulla E,
    3. Flipo RM,
    4. Cortet B,
    5. Cotten A
    . MR imaging findings in hands in early rheumatoid arthritis: comparison with those in systemic lupus erythematosus and primary Sjogren syndrome. Radiology 2005;236:593–600.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Eshed I,
    2. Feist E,
    3. Althoff CE,
    4. Backhaus M,
    5. Burmester GR,
    6. Hamm B,
    7. et al.
    Early rheumatoid arthritis-do we really know what it means? Consistency and distribution of MRI findings according to different definitions for early rheumatoid arthritis. Clin Rheumatol 2011;30:551–5.
    OpenUrlPubMed
  3. 3.↵
    1. Nieuwenhuis WP,
    2. Krabben A,
    3. Stomp W,
    4. Huizinga TW,
    5. van der Heijde D,
    6. Bloem JL,
    7. et al.
    Evaluation of magnetic resonance imaging-detected tenosynovitis in the hand and wrist in early arthritis. Arthritis Rheumatol 2015;67:869–76.
    OpenUrl
  4. 4.↵
    1. McQueen F,
    2. Beckley V,
    3. Crabbe J,
    4. Robinson E,
    5. Yeoman S,
    6. Stewart N
    . Magnetic resonance imaging evidence of tendinopathy in early rheumatoid arthritis predicts tendon rupture at six years. Arthritis Rheum 2005;52:744–51.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Lillegraven S,
    2. Boyesen P,
    3. Hammer HB,
    4. Ostergaard M,
    5. Uhlig T,
    6. Sesseng S,
    7. et al.
    Tenosynovitis of the extensor carpi ulnaris tendon predicts erosive progression in early rheumatoid arthritis. Ann Rheum Dis 2011;70:2049–50.
    OpenUrlFREE Full Text
  6. 6.↵
    1. Ostergaard M,
    2. Peterfy C,
    3. Conaghan P,
    4. McQueen F,
    5. Bird P,
    6. Ejbjerg B,
    7. et al.
    OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol 2003;30:1385–6.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Glinatsi D,
    2. Lillegraven S,
    3. Haavardsholm EA,
    4. Eshed I,
    5. Conaghan PG,
    6. Peterfy C,
    7. et al.
    Validation of the OMERACT magnetic resonance imaging joint space narrowing score for the wrist in a multireader longitudinal trial. J Rheumatol 2015;42:2480–5.
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Haavardsholm EA,
    2. Ostergaard M,
    3. Ejbjerg BJ,
    4. Kvan NP,
    5. Kvien TK
    . Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study. Ann Rheum Dis 2007;66:1216–20.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Haavardsholm EA,
    2. Ostergaard M,
    3. Hammer HB,
    4. Boyesen P,
    5. Boonen A,
    6. van der Heijde D,
    7. et al.
    Monitoring anti-TNFalpha treatment in rheumatoid arthritis: responsiveness of magnetic resonance imaging and ultrasonography of the dominant wrist joint compared with conventional measures of disease activity and structural damage. Ann Rheum Dis 2009;68:1572–9.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Boyesen P,
    2. McQueen FM,
    3. Gandjbakhch F,
    4. Lillegraven S,
    5. Coates L,
    6. Wiell C,
    7. et al.
    The OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) is reliable and sensitive to change: results from an OMERACT workshop. J Rheumatol 2011;38:2034–8.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Glinatsi D,
    2. Bird P,
    3. Gandjbakhch F,
    4. Mease PJ,
    5. Boyesen P,
    6. Peterfy CG,
    7. et al.
    Validation of the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) for the hand and foot in a randomized placebo-controlled trial. J Rheumatol 2015;42:2473–9.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Ostergaard M,
    2. McQueen F,
    3. Wiell C,
    4. Bird P,
    5. Boyesen P,
    6. Ejbjerg B,
    7. et al.
    The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA Hands. J Rheumatol 2009;36:1816–24.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Vital EM,
    2. Dass S,
    3. Buch MH,
    4. Rawstron AC,
    5. Emery P
    . An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete B cell depletion: a randomised controlled trial. Ann Rheum Dis 2015;74:1195–201.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. van Tuyl LH,
    2. van der Heijde D,
    3. Knol DL,
    4. Boers M
    . Chronological reading of radiographs in rheumatoid arthritis increases efficiency and does not lead to bias. Ann Rheum Dis 2014;73:391–5.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Bruynesteyn K,
    2. Boers M,
    3. Kostense P,
    4. van der Linden S,
    5. van der Heijde D
    . Deciding on progression of joint damage in paired films of individual patients: smallest detectable difference or change. Ann Rheum Dis 2005;64:179–82.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Matsumoto T,
    2. Tsurumoto T,
    3. Shindo H,
    4. Uetani M
    . Comparative study of fat-suppressed Gd-enhanced MRI of hands in the early stage of rheumatoid arthritis (RA) and non-RA. Mod Rheumatol 2001;11:56–60.
    OpenUrl
  17. 17.↵
    1. Eshed I,
    2. Feist E,
    3. Althoff CE,
    4. Hamm B,
    5. Konen E,
    6. Burmester GR,
    7. et al.
    Tenosynovitis of the flexor tendons of the hand detected by MRI: an early indicator of rheumatoid arthritis. Rheumatology 2009;48:887–91.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Klarlund M,
    2. Ostergaard M,
    3. Jensen KE,
    4. Madsen JL,
    5. Skjodt H,
    6. Lorenzen I
    . Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis. The TIRA Group. Ann Rheum Dis 2000;59:521–8.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Krabben A,
    2. Stomp W,
    3. Huizinga TW,
    4. van der Heijde D,
    5. Bloem JL,
    6. Reijnierse M,
    7. et al.
    Concordance between inflammation at physical examination and on MRI in patients with early arthritis. Ann Rheum Dis 2015;74:506–12.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Lindegaard HM,
    2. Vallo J,
    3. Horslev-Petersen K,
    4. Junker P,
    5. Ostergaard M
    . Low-cost, low-field dedicated extremity magnetic resonance imaging in early rheumatoid arthritis: a 1-year follow-up study. Ann Rheum Dis 2006;65:1208–12.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Narvaez J,
    2. Narvaez JA,
    3. de Albert M,
    4. Gomez-Vaquero C,
    5. Nolla JM
    . Can magnetic resonance imaging of the hand and wrist differentiate between rheumatoid arthritis and psoriatic arthritis in the early stages of the disease? Semin Arthritis Rheum 2012;42:234–45.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Wakefield RJ,
    2. O’Connor PJ,
    3. Conaghan PG,
    4. McGonagle D,
    5. Hensor EM,
    6. Gibbon WW,
    7. et al.
    Finger tendon disease in untreated early rheumatoid arthritis: a comparison of ultrasound and magnetic resonance imaging. Arthritis Rheum 2007;57:1158–64.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. McQueen FM,
    2. Stewart N,
    3. Crabbe J,
    4. Robinson E,
    5. Yeoman S,
    6. Tan PL,
    7. et al.
    Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset. Ann Rheum Dis 1998;57:350–6.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Schirmer C,
    2. Scheel AK,
    3. Althoff CE,
    4. Schink T,
    5. Eshed I,
    6. Lembcke A,
    7. et al.
    Diagnostic quality and scoring of synovitis, tenosynovitis and erosions in low-field MRI of patients with rheumatoid arthritis: a comparison with conventional MRI. Ann Rheum Dis 2007;66:522–9.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Lisbona MP,
    2. Maymo J,
    3. Perich J,
    4. Almirall M,
    5. Carbonell J
    . Rapid reduction in tenosynovitis of the wrist and fingers evaluated by MRI in patients with rheumatoid arthritis after treatment with etanercept. Ann Rheum Dis 2010;69:1117–22.
    OpenUrlAbstract/FREE Full Text
  26. 26.↵
    1. Ostergaard M,
    2. Boyesen P,
    3. Eshed I,
    4. Gandjbakhch F,
    5. Lillegraven S,
    6. Bird P,
    7. et al.
    Development and preliminary validation of a magnetic resonance imaging joint space narrowing score for use in rheumatoid arthritis: potential adjunct to the OMERACT RA MRI scoring system. J Rheumatol 2011;38:2045–50.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Boers M,
    2. Kirwan JR,
    3. Gossec L,
    4. Conaghan PG,
    5. D’Agostino MA,
    6. Bingham CO,
    7. et al.
    How to choose core outcome measurement sets for clinical trials: OMERACT 11 approves filter 2.0. J Rheumatol 2014;41:1025–30.
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The Journal of Rheumatology
Vol. 44, Issue 11
1 Nov 2017
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Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise
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Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise
Daniel Glinatsi, Paul Bird, Frédérique Gandjbakhch, Espen A. Haavardsholm, Charles G. Peterfy, Edward M. Vital, Paul Emery, Philip G. Conaghan, Mikkel Østergaard
The Journal of Rheumatology Nov 2017, 44 (11) 1688-1693; DOI: 10.3899/jrheum.161097

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Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise
Daniel Glinatsi, Paul Bird, Frédérique Gandjbakhch, Espen A. Haavardsholm, Charles G. Peterfy, Edward M. Vital, Paul Emery, Philip G. Conaghan, Mikkel Østergaard
The Journal of Rheumatology Nov 2017, 44 (11) 1688-1693; DOI: 10.3899/jrheum.161097
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    • MATERIALS AND METHODS
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Keywords

MAGNETIC RESONANCE IMAGING
TENOSYNOVITIS
RHEUMATOID ARTHRITIS
OMERACT

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More in this TOC Section

OMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

  • Critical Outcomes in Longitudinal Observational Studies and Registries in Patients with Rheumatoid Arthritis: An OMERACT Special Interest Group Report
  • Development of a Core Set of Outcome Measures for Large-vessel Vasculitis: Report from OMERACT 2016
  • The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions
Show more OMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

Special Interest Groups, Part 1

  • Critical Outcomes in Longitudinal Observational Studies and Registries in Patients with Rheumatoid Arthritis: An OMERACT Special Interest Group Report
  • Development of a Core Set of Outcome Measures for Large-vessel Vasculitis: Report from OMERACT 2016
  • The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions
Show more Special Interest Groups, Part 1

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  • TENOSYNOVITIS
  • rheumatoid arthritis
  • OMERACT

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