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Research ArticleArticle

Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies

Robin L. Thurmond, Andrew Greenspan, Waldemar Radziszewski, Xie L. Xu, Ye Miao, Bin Chen, TingTing Ge, Bei Zhou, Daniel G. Baker, Dace Pavlova, Christopher T. Ritchlin, Yoshiya Tanaka, Tsutomu Takeuchi and Josef S. Smolen
The Journal of Rheumatology September 2016, 43 (9) 1637-1642; DOI: https://doi.org/10.3899/jrheum.160164
Robin L. Thurmond
From the Immunology department, Janssen Research & Development, LLC, San Diego, California; the Medical Affairs department, Janssen Research & Development, LLC, Horsham, Pennsylvania; the Biostatistics department and the Immunology department, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA; Early Development, Janssen China Research and Development, Shanghai, China; the Biostatistics department, Janssen Research & Development, LLC, Belmont, Massachusetts, USA; Rheumatology Department, M&M Centers LTD., Adazi, Latvia; Immunology Department, University of Rochester, Rochester, New York, USA; Internal Medicine, University of Occupational and Environmental Health, Kitakyushu; Rheumatology, Keio University Hospital, Tokyo, Japan; Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria.
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  • For correspondence: RThurmon{at}its.jnj.com
Andrew Greenspan
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Waldemar Radziszewski
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Xie L. Xu
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Ye Miao
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Bin Chen
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TingTing Ge
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Bei Zhou
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Daniel G. Baker
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Dace Pavlova
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Christopher T. Ritchlin
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Yoshiya Tanaka
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Tsutomu Takeuchi
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Josef S. Smolen
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Article Information

vol. 43 no. 9 1637-1642
DOI 
https://doi.org/10.3899/jrheum.160164
PubMed 
27422891

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication May 20, 2016
  • Published online September 1, 2016.

Article Versions

  • Latest version (July 15, 2016 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016

Author Information

  1. Robin L. Thurmond⇑,
  2. Andrew Greenspan,
  3. Waldemar Radziszewski,
  4. Xie L. Xu,
  5. Ye Miao,
  6. Bin Chen,
  7. TingTing Ge,
  8. Bei Zhou,
  9. Daniel G. Baker,
  10. Dace Pavlova,
  11. Christopher T. Ritchlin,
  12. Yoshiya Tanaka,
  13. Tsutomu Takeuchi and
  14. Josef S. Smolen
  1. From the Immunology department, Janssen Research & Development, LLC, San Diego, California; the Medical Affairs department, Janssen Research & Development, LLC, Horsham, Pennsylvania; the Biostatistics department and the Immunology department, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA; Early Development, Janssen China Research and Development, Shanghai, China; the Biostatistics department, Janssen Research & Development, LLC, Belmont, Massachusetts, USA; Rheumatology Department, M&M Centers LTD., Adazi, Latvia; Immunology Department, University of Rochester, Rochester, New York, USA; Internal Medicine, University of Occupational and Environmental Health, Kitakyushu; Rheumatology, Keio University Hospital, Tokyo, Japan; Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria.
  2. R.L. Thurmond, PhD, Immunology Department, Janssen Research & Development, LLC; A. Greenspan, MD, Medical Affairs Department, Janssen Research & Development, LLC; W. Radziszewski, MD, PhD, Immunology Department, Janssen Research & Development, LLC; X.L. Xu, PhD, Immunology Department, Janssen Research & Development, LLC; Y. Miao, MS, Biostatistics Department, Janssen Research & Development, LLC; B. Chen, PhD, Early Development, Janssen China Research and Development; T. Ge, PhD, Biostatistics Department, Janssen Research & Development, LLC; B. Zhou, PhD, Biostatistics, Janssen Research & Development, LLC; D.G. Baker, MD, Immunology Department, Janssen Research & Development, LLC; D. Pavlova, MD, Rheumatology, M&M Centers Ltd.; C.T. Ritchlin, MD, Immunology Department, University of Rochester; Y. Tanaka, MD, PhD, Internal Medicine, University of Occupational and Environmental Health; T. Takeuchi, MD, PhD, Rheumatology, Keio University Hospital; J.S. Smolen, MD, Rheumatology, Medical University of Vienna and Hietzing Hospital.
  1. Address correspondence to R.L. Thurmond, Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, USA. E-mail: RThurmon{at}its.jnj.com

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The Journal of Rheumatology
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1 Sep 2016
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Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies
Robin L. Thurmond, Andrew Greenspan, Waldemar Radziszewski, Xie L. Xu, Ye Miao, Bin Chen, TingTing Ge, Bei Zhou, Daniel G. Baker, Dace Pavlova, Christopher T. Ritchlin, Yoshiya Tanaka, Tsutomu Takeuchi, Josef S. Smolen
The Journal of Rheumatology Sep 2016, 43 (9) 1637-1642; DOI: 10.3899/jrheum.160164

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Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies
Robin L. Thurmond, Andrew Greenspan, Waldemar Radziszewski, Xie L. Xu, Ye Miao, Bin Chen, TingTing Ge, Bei Zhou, Daniel G. Baker, Dace Pavlova, Christopher T. Ritchlin, Yoshiya Tanaka, Tsutomu Takeuchi, Josef S. Smolen
The Journal of Rheumatology Sep 2016, 43 (9) 1637-1642; DOI: 10.3899/jrheum.160164
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Keywords

HISTAMINE H4 RECEPTOR ANTAGONIST
RHEUMATOID ARTHRITIS
METHOTREXATE
CLINICAL TRIAL

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Keywords

  • HISTAMINE H4 RECEPTOR ANTAGONIST
  • rheumatoid arthritis
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