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Characteristics 1/3 Sample, Part 1 2/3 Sample, Part 2 Sample size, n 335 678 Female sex, n (%) 301 (89.9) 604 (89.1) Age, yrs, mean ± SD 43.7 ± 11.0 42.4 ± 10.8 Disease duration, yrs, mean ± SD 10.0 ± 9.2 9.4 ± 8.8 CAD, n (%) 33 (9.9) 62 (9.1) hsCRP, (n) mean ± SD (n = 90) 4.5 ± 8.6 (208) 7.3 ± 13.9 Elevated, (n) n (%) (n = 90) 30 (33.3) (208) 85 (40.9) Current smoker, n (%) 70 (20.9) 124 (18.3) Blood pressure, mean ± SD Diastolic 78.5 ± 10.7 78.0 ± 11.3 Systolic 126.3 ± 19.4 124.4 ± 18.4 Cholesterol, mean ± SD 5.2 ± 1.6 5.1 ± 1.3 Elevated, n (%) 131 (39.3) 268 (40.2) HDL, mean ± SD Original, (n) mean ± SD (n = 109) 1.6 ± 0.5 (184) 1.5 ± 0.5 Imputed, (n) mean ± SD (n = 335) 1.6 ± 0.4 (687) 1.6 ± 0.3 Time to CAD/last clinic visit, yrs, mean ± SD 6.3 ± 3.5 5.7 ± 3.5 CAD: coronary artery disease; hsCRP: high-sensitivity C-reactive protein; HDL: high-density lipoprotein.
- Table 2.
Sensitivity and specificity for the FRS and the mFRS using a multiplier of 1.5, 2, 3, or 4.
Variable Moderate/high Risk, % Sensitivity Specificity Sensitivity 95% CI Specificity 95% CI FRS 2.9 13.0 0–26.6 98.2 96.3–100.0 1.5 FRS 11.5 19.7 3.7–35.7 89.4 85.2–93.5 2 FRS 20.3 31.5 13.3–49.7 80.9 76.1–85.7 3 FRS 29.7 45.5 26.8–64.1 72.0 66.6–77.5 4 FRS 32.7 46.1 27.4–64.7 68.8 63.1–74.5 FRS: Framingham Risk Factor Score; mFRS: modified FRS.
- Table 3.
Results of multivariate time-dependent analysis for coronary artery disease using the FRS and 2FRS.
Model Variable HR 95% CI p FRS only FRS 3.215 0.941–10.990 0.066 FRS and AMS AMS 1.058 1.013–1.106 0.0109 FRS 3.440 0.999–11.850 0.0536 FRS and SLEDAI-2K FRS 3.495 1.019–11.990 0.0499 SLEDAI-2K 1.060 1.021–1.100 0.002 FRS and treatment Antimalarial 0.682 0.412–1.130 0.1371 FRS 3.253 0.935–11.320 0.0674 Immunosuppressive 1.008 0.582–1.745 0.9775 Steroids 3.254 1.706–6.205 0.0003 2FRS only 2FRS 4.368 2.404–7.936 < 0.0001 2FRS and AMS AMS 1.061 1.012–1.113 0.016 2FRS 4.529 2.443–8.396 < 0.0001 2FRS and SLEDAI-2K 2FRS 4.563 2.451–8.493 < 0.0001 SLEDAI-2K 1.063 1.021–1.107 0.0035 2FRS and treatment Antimalarial 0.709 0.429–1.173 0.1806 2FRS 4.655 2.535–8.545 < 0.0001 Immunosuppressive 1.097 0.633–1.901 0.7412 Steroids 3.413 1.787–6.519 0.0002 FRS: Framingham Risk Factor Score; 2FRS: FRS with a multiplier of 2; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; AMS: adjusted mean SLEDAI.