Article Figures & Data
Figures
- Figure 1.
Standardized path coefficients (controlling for serum creatinine and ethnicity) from the path analysis investigating putative causal pathways of bone erosion in gout. Total R2 = 0.58, p < 0.0001. RANKL: receptor activator of nuclear factor-κB ligand; OPG: osteoprotegerin; CT: computed tomography.
Tables
- Table 1.
Clinical characteristics and their correlations with CT erosion score. Data are mean (SD) unless indicated otherwise.
Clinical Features Pearson r P Age, yrs 56 (12) −0.05 0.66 Male sex, n (%) 94 (94) — 0.24† Ethnicity, n (%) — 0.03† Pacific 42 (42) Māori 18 (18) Non-Māori, non-Pacific 40 (40) Gout disease duration, yrs 22 (11) 0.20 0.051 No. subcutaneous tophi 7.3 (7.1) 0.62 < 0.001 Serum urate, mmol/l 0.38 (0.12) 0.22 0.29 Serum creatinine, μmol/l 97 (23) 0.34 0.001 RANKL concentration, pmol/l 0.28 (0.65) 0.44 0.001 OPG concentration, pg/ml 2214 (1272) 0.27 0.006 Sclerostin concentration, pg/ml 696 (338) −0.29 0.003 DKK-1 concentration, pg/ml 3412 (1992) −0.08 0.46 FGF-23 concentration, pg/ml 7.1 (11.8) 0.18 0.08 P1NP concentration, μg/l 56.9 (33.3) 0.16 0.12 β-CTX concentration, ng/ml 0.29 (0.16) 0.07 0.46 Pearson r and p refer to correlation with CT erosion score.
↵† P value shown for comparison of erosion scores between groups. CT: computed tomography; RANKL: receptor activator of nuclear factor-κB ligand; OPG: osteoprotegerin; DKK: Dickkopf 1; FGF-23: fibroblast growth factor 23; P1NP: procollagen type-1 N-terminal propeptide; CTX: collagen cross-linked C-telopeptide, type I.
- Table 2.
Multiple linear regression analysis. Standardized β coefficient, partial R2 and regression p are shown for those variables that met an inclusion criterion of p < 0.15 from a fully saturated model of variables selected from external clinical judgment, for an association with erosion score.
Clinical Features Model Constructed from External Clinical Judgment Reduced Model (F = 17.8, R2 = 0.58, p < 0.0001) Standardized β Coefficient p Standardized β Coefficient p Partial R2 Age −0.045 0.635 Sex 0.023 0.769 Māori or Pacific ethnicity 0.169 0.048 0.171 0.016 5% Gout disease duration 0.088 0.259 Total no. tophi 0.459 < 0.0001 0.460 < 0.0001 39% Serum urate 0.057 0.469 Serum creatinine 0.182 0.038 0.222 0.004 5% RANKL concentration 0.184 0.041 0.209 0.009 3% OPG concentration 0.142 0.119 0.158 0.036 2% Sclerostin concentration −0.168 0.028 −0.172 0.019 3% DKK-1 concentration −0.060 0.480 FGF-23 concentration 0.012 0.892 P1NP concentration 0.122 0.197 β-CTX concentration −0.222 0.033 −0.12588 0.103 RANKL: receptor activator of nuclear factor-κB ligand; OPG: osteoprotegerin; DKK: Dickkopf 1; FGF-23: fibroblast growth factor 23; P1NP: procollagen type-1 N-terminal propeptide; CTX: collagen cross-linked C-telopeptide, type I.
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