Article Figures & Data
Tables
- Table 1.
Demographic and clinical data. Values are mean (range) unless otherwise specified.
Variable Treatment Change, n = 161 No Treatment Change, n = 342 Combined, n = 503 Age, yrs 50.0 (20–84) 51.2 (19–87) 50.8 (19–87) Male/female, n 89/72 197/145 286/217 PsA duration, yrs 8.9 (0.1–51) 10.2 (0.1–54) 9.8 (0.1–54) Psoriasis duration, yrs 17.5 (0.1–55) 18.7 (0.3–68) 18.4 (0.1–68) TJC 10.2 (0–57) 5.9 (0–66) 7.2 (0–66) SJC 4.4 (0–50) 2.9 (0–62) 3.4 (0–62) PASI 5.1 (0–45) 3.8 (0–58) 4.2 (0–58) HAQ 1.03 (0–2.88) 0.59 (0–2.88) 0.73 (0–2.88) PASDAS 5.3 (1.5–8.3) 3.8 (0.4–9.0) 4.3 (0.4–9.0) CPDAI 6.8 (1–13) 4.8 (1–13) 5.4 (1–13) MDA, n (%) 12 (7.5) 103 (30) 115 (23) PsA: psoriatic arthritis; TJC: tender joint count; SJC: swollen joint count; PASI: Psoriasis Area and Severity Index; CPDAI: Composite Psoriatic Disease Activity Index; PASDAS: Psoriatic Arthritis Disease Activity Score; HAQ: Health Assessment Questionnaire; MDA: minimal disease activity.
- Table 2.
Relationship between MDA-5 and other indices of low disease activity. The established MDA criteria (MDA-5) serve as the reference, or “gold standard.” The performance of the other measures listed in column 1 is tested against this standard. The performance statistics are represented by sensitivity, specificity, overall accuracy, PPV, NPV, Youden index, and bias-adjusted κ statistic. Values are % unless otherwise specified.
Variables Sensitivity Specificity Overall Accuracy PPV NPV Youden Index κ* MDA-joints 70 100 93 100 92 70 0.86 PASDAS 83 87 86 68 94 70 0.73 CPDAI-4 96 72 78 52 98 68 0.75 CPDAI-3 91 86 87 68 97 77 0.75 ↵* κ: prevalence adjusted, bias adjusted κ. MDA: minimal disease activity; MDA-5: MDA criteria with 5 items required; PPV: positive predictive value; NPV: negative predictive value; MDA-joints: MDA criteria mandating the articular items; PASDAS: Psoriatic Arthritis Disease Activity Score; CPDAI: Composite Psoriatic Disease Activity Index; CPDAI-4: CPDAI score with 4 as cutoff; CPDAI-3: CPDAI score with 3 as cutoff.
- Table 3.
Cross-tabulation of various assessments of low disease activity compared to (1) MDA as judged by the treating physician (MDAphys) and (2) disease control as reported by the patient (DWCpatient). MDAphys and DWCpatient serve as the reference, or “gold standard.” The performance of the other measures listed were tested against this standard. The performance statistics are represented by sensitivity, specificity, overall accuracy, PPV, NPV, Youden index, and bias-adjusted κ statistic. Values are % unless otherwise specified.
Variables Cutoff for Low Disease Activity Sensitivity Specificity Overall Accuracy PPV NPV Youden Index κ* MDAphys MDA-5 5 46 93 74 81 72 39 0.48 MDA-6 6 29 99 71 94 68 28 0.42 MDA-7 7 15 100 66 96 64 15 0.32 MDA-joints 5 35 97 72 87 69 32 0.44 PASDAS 3.2 64 93 82 85 80 57 0.63 CPDAI-4 4 69 76 73 67 78 45 0.46 CPDAI-3 3 58 88 75 77 75 46 0.51 DWC MDA-5 5 40 98 65 96 55 38 0.30 MDA-6 6 25 100 57 100 50 25 0.14 MDA-7 7 13 100 50 100 46 13 0.01 MDA-joints 5 29 99 59 99 51 28 0.18 PASDAS 3.2 52 98 72 97 61 50 0.44 CPDAI-4 4 63 82 71 83 62 45 0.43 CPDAI-3 3 51 94 69 92 58 45 0.38 ↵* κ: prevalence adjusted, bias adjusted κ. MDA: minimal disease activity; PPV: positive predictive value; NPV: negative predictive value; MDA-5: MDA criteria with 5 items required; MDA-6: MDA criteria with 6 items required; MDA-7: MDA criteria with 7 items required; MDA-joints: MDA criteria mandating the articular items; PASDAS: Psoriatic Arthritis Disease Activity Score; CPDAI: Composite Psoriatic Disease Activity Index; CPDAI-4: CPDAI score with 4 as cutoff; CPDAI-3: CPDAI score with 3 as cutoff.
- Table 4.
Values of PASDAS and CPDAI according to different definitions of low disease activity.
Variables In Low Disease Activity by Criteria Not in Low Disease Activity by Criteria Z* Median Mean Range Median Mean Range PASDAS MDA-5 2.35 2.41 0.43–5.11 4.96 4.90 1.82–9.00 12.0 MDA-6 1.88 1.90 0.43–3.41 4.66 4.69 1.37–9.00 10.6 MDA-7 1.42 1.51 0.43–3.23 4.46 4.52 1.37–9.00 8.2 MDA-joints 2.04 2.18 0.43–5.11 4.74 4.73 1.67–9.00 10.7 CPDAI MDA-5 2 2.38 1–6 6 6.36 1–13 13.4 MDA-6 2 2.14 1–6 6 5.96 1–13 10.8 MDA-7 2 1.86 1–3 5 5.72 1–13 8.5 MDA-joints 2 2.21 1–6 6 6.09 1–13 11.8 ↵* Z statistic from Mann-Whitney U test. All values are highly significant. PASDAS: Psoriatic Arthritis Disease Activity Score; CPDAI: Composite Psoriatic Disease Activity Index; MDA-5: MDA criteria with 5 items required; MDA-6: MDA criteria with 6 items required; MDA-7: MDA criteria with 7 items required; MDA-joints: MDA criteria mandating the articular items.
