Research ArticleArticle
Differences in Predictive Factors for Sustained Clinical Remission with Abatacept Between Younger and Elderly Patients with Biologic-naive Rheumatoid Arthritis: Results from the ABROAD Study
Masahiro Sekiguchi, Takao Fujii, Kiyoshi Matsui, Kosaku Murakami, Satoshi Morita, Koichiro Ohmura, Yutaka Kawahito, Norihiro Nishimoto, Tsuneyo Mimori, Hajime Sano and The ABROAD Study Investigators
The Journal of Rheumatology November 2016, 43 (11) 1974-1983; DOI: https://doi.org/10.3899/jrheum.160051
Masahiro Sekiguchi
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Takao Fujii
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Kiyoshi Matsui
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Kosaku Murakami
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Satoshi Morita
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Koichiro Ohmura
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Yutaka Kawahito
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Norihiro Nishimoto
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Tsuneyo Mimori
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
Hajime Sano
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
From the Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Rheumatology and Clinical Immunology, and the Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University; Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto; Osaka Rheumatology Clinic and Institute of Medical Science, Osaka; Tokyo Medical University, Tokyo,
Japan.
M. Sekiguchi, MD, PhD, Hyogo College of Medicine; T. Fujii, MD, PhD, Graduate School of Medicine, Kyoto University; K. Matsui, MD, PhD, Hyogo College of Medicine; K. Murakami, MD, PhD, Graduate School of Medicine, Kyoto University; S. Morita, MD, PhD, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Graduate School of Medicine, Kyoto University; Y. Kawahito, MD, PhD, Graduate School of Medical Science, Kyoto Prefectural University of Medicine; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic and Institute of Medical Science, Tokyo Medical University; T. Mimori, MD, PhD, Graduate School of Medicine, Kyoto University; H. Sano, MD, PhD, Hyogo College of Medicine. Dr. Sekiguchi and Dr. Fujii contributed equally to this study.
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In this issue
The Journal of Rheumatology
Vol. 43, Issue 11
1 Nov 2016
Differences in Predictive Factors for Sustained Clinical Remission with Abatacept Between Younger and Elderly Patients with Biologic-naive Rheumatoid Arthritis: Results from the ABROAD Study
Masahiro Sekiguchi, Takao Fujii, Kiyoshi Matsui, Kosaku Murakami, Satoshi Morita, Koichiro Ohmura, Yutaka Kawahito, Norihiro Nishimoto, Tsuneyo Mimori, Hajime Sano, The ABROAD Study Investigators
The Journal of Rheumatology Nov 2016, 43 (11) 1974-1983; DOI: 10.3899/jrheum.160051
Differences in Predictive Factors for Sustained Clinical Remission with Abatacept Between Younger and Elderly Patients with Biologic-naive Rheumatoid Arthritis: Results from the ABROAD Study
Masahiro Sekiguchi, Takao Fujii, Kiyoshi Matsui, Kosaku Murakami, Satoshi Morita, Koichiro Ohmura, Yutaka Kawahito, Norihiro Nishimoto, Tsuneyo Mimori, Hajime Sano, The ABROAD Study Investigators
The Journal of Rheumatology Nov 2016, 43 (11) 1974-1983; DOI: 10.3899/jrheum.160051