Hybrid 18F-labeled Fluoride Positron Emission Tomography/Magnetic Resonance (MR) Imaging of the Sacroiliac Joints and the Spine in Patients with Axial Spondyloarthritis: A Pilot Study Exploring the Link of MR Bone Pathologies and Increased Osteoblastic Activity

Christian Buchbender; Benedikt Ostendorf; Verena Ruhlmann; Philipp Heusch; Falk Miese; Karsten Beiderwellen; Matthias Schneider; Juergen Braun; Gerald Antoch; Xenofon Baraliakos

doi:10.3899/jrheum.150250

REFERENCES

1.↵
1. Braun J,
2. Sieper J
. Ankylosing spondylitis. Lancet 2007;369:1379–90.
OpenUrl CrossRef PubMed
2.↵
1. van der Heijde D,
2. Sieper J,
3. Maksymowych WP,
4. Dougados M,
5. Burgos-Vargas R,
6. Landewé R,
7. et al;
8. Assessment of SpondyloArthritis international Society
. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis. Ann Rheum Dis 2011;70:905–8.
OpenUrl Abstract/FREE Full Text
3.↵
1. Braun J,
2. van den Berg R,
3. Baraliakos X,
4. Boehm H,
5. Burgos-Vargas R,
6. Collantes-Estevez E,
7. et al.
2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2011;70:896–904.
OpenUrl Abstract/FREE Full Text
4.↵
1. Rudwaleit M,
2. Listing J,
3. Brandt J,
4. Braun J,
5. Sieper J
. Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis 2004;63:665–70.
OpenUrl Abstract/FREE Full Text
5.↵
1. Baraliakos X,
2. Listing J,
3. Rudwaleit M,
4. Haibel H,
5. Brandt J,
6. Sieper J,
7. et al.
Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes. Ann Rheum Dis 2007;66:910–5.
OpenUrl Abstract/FREE Full Text
6.↵
1. Baraliakos X,
2. Listing J,
3. Rudwaleit M,
4. Sieper J,
5. Braun J
. The relationship between inflammation and new bone formation in patients with ankylosing spondylitis. Arthritis Res Ther 2008;10:R104.
OpenUrl CrossRef PubMed
7.↵
1. Baraliakos X,
2. Listing J,
3. Fritz C,
4. Haibel H,
5. Alten R,
6. Burmester GR,
7. et al.
Persistent clinical efficacy and safety of infliximab in ankylosing spondylitis after 8 years—early clinical response predicts long-term outcome. Rheumatology 2011;50:1690–9.
OpenUrl Abstract/FREE Full Text
8.↵
1. Baraliakos X,
2. Heldmann F,
3. Callhoff J,
4. Listing J,
5. Appelboom T,
6. Brandt J,
7. et al.
Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. Ann Rheum Dis 2014;73:1819–25.
OpenUrl Abstract/FREE Full Text
9.↵
1. Buchbender C,
2. Sewerin P,
3. Mattes-György K,
4. Miese F,
5. Wittsack HJ,
6. Specker C,
7. et al.
Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression. Eur J Radiol 2013;82:374–9.
OpenUrl CrossRef PubMed
10.↵
1. Hawkins RA,
2. Choi Y,
3. Huang SC,
4. Hoh CK,
5. Dahlbom M,
6. Schiepers C,
7. et al.
Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med 1992;33:633–42.
OpenUrl Abstract/FREE Full Text
11.↵
1. Fischer DR,
2. Pfirrmann CW,
3. Zubler V,
4. Stumpe KD,
5. Seifert B,
6. Strobel K,
7. et al.
High bone turnover assessed by 18F-fluoride PET/CT in the spine and sacroiliac joints of patients with ankylosing spondylitis: comparison with inflammatory lesions detected by whole body MRI. EJNMMI Res 2012;2:38.
OpenUrl CrossRef PubMed
12.↵
1. Bruijnen ST,
2. van der Weijden MA,
3. Klein JP,
4. Hoekstra OS,
5. Boellaard R,
6. van Denderen JC,
7. et al.
Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study. Arthritis Res Ther 2012;14:R71.
OpenUrl CrossRef PubMed
13.↵
1. van der Linden S,
2. Valkenburg HA,
3. Cats A
. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361–8.
OpenUrl CrossRef PubMed
14.↵
1. Garrett S,
2. Jenkinson T,
3. Kennedy LG,
4. Whitelock H,
5. Gaisford P,
6. Calin A
. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994;21:2286–91.
OpenUrl PubMed
15.↵
1. Baraliakos X,
2. Listing J,
3. von der Recke A,
4. Braun J
. The natural course of radiographic progression in ankylosing spondylitis—evidence for major individual variations in a large proportion of patients. J Rheumatol 2009;36:997–1002.
OpenUrl Abstract/FREE Full Text
16.↵
1. Buchbender C,
2. Heusner TA,
3. Lauenstein TC,
4. Bockisch A,
5. Antoch G
. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis. J Nucl Med 2012;53:928–38.
OpenUrl Abstract/FREE Full Text
17.↵
1. Buchbender C,
2. Schneider M,
3. Ostendorf B
. [Magnetic resonance tomography and hybrid imaging in rheumatology]. [Article in German] Z Rheumatol 2013;72:137–44.
OpenUrl CrossRef PubMed
18.↵
1. Weber U,
2. Lambert RG,
3. Pedersen SJ,
4. Hodler J,
5. Ostergaard M,
6. Maksymowych WP
. Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis. Arthritis Care Res 2010;62:1763–71.
OpenUrl PubMed
19.↵
1. Wick MC,
2. Weiss RJ,
3. Jaschke W,
4. Klauser AS
. Erosions are the most relevant magnetic resonance imaging features in quantification of sacroiliac joints in ankylosing spondylitis. J Rheumatol 2010;37:622–7.
OpenUrl Abstract/FREE Full Text
20.↵
1. Sieper J,
2. Rudwaleit M,
3. Baraliakos X,
4. Brandt J,
5. Braun J,
6. Burgos-Vargas R,
7. et al.
The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 2009;68 Suppl 2:ii1–44.
OpenUrl Abstract/FREE Full Text
21.↵
1. van der Heijde D,
2. Sieper J,
3. Maksymowych WP,
4. Brown MA,
5. Lambert RG,
6. Rathmann SS,
7. et al.
Spinal inflammation in the absence of sacroiliac joint inflammation on magnetic resonance imaging in patients with active nonradiographic axial spondyloarthritis. Arthritis Rheumatol 2014;66:667–73.
OpenUrl CrossRef PubMed

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Keywords

AXIAL SPONDYLOARTHRITIS

SPONDYLOARTHRITIDES

ANKYLOSING SPONDYLITIS

PET/MRI

MR-PET

Cited By...

More in this TOC Section

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Keywords

[1] 1.↵
Braun J,
Sieper J
. Ankylosing spondylitis. Lancet 2007;369:1379–90.
OpenUrl CrossRef PubMed

[2] Braun J,

[3] Sieper J

[4] 2.↵
van der Heijde D,
Sieper J,
Maksymowych WP,
Dougados M,
Burgos-Vargas R,
Landewé R,
et al;
Assessment of SpondyloArthritis international Society
. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis. Ann Rheum Dis 2011;70:905–8.
OpenUrl Abstract/FREE Full Text

[5] van der Heijde D,

[6] Sieper J,

[7] Maksymowych WP,

[8] Dougados M,

[9] Burgos-Vargas R,

[10] Landewé R,

[11] et al;

[12] Assessment of SpondyloArthritis international Society

[13] 3.↵
Braun J,
van den Berg R,
Baraliakos X,
Boehm H,
Burgos-Vargas R,
Collantes-Estevez E,
et al.
2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2011;70:896–904.
OpenUrl Abstract/FREE Full Text

[14] Braun J,

[15] van den Berg R,

[16] Baraliakos X,

[17] Boehm H,

[18] Burgos-Vargas R,

[19] Collantes-Estevez E,

[20] et al.

[21] 4.↵
Rudwaleit M,
Listing J,
Brandt J,
Braun J,
Sieper J
. Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis 2004;63:665–70.
OpenUrl Abstract/FREE Full Text

[22] Rudwaleit M,

[23] Listing J,

[24] Brandt J,

[25] Braun J,

[26] Sieper J

[27] 5.↵
Baraliakos X,
Listing J,
Rudwaleit M,
Haibel H,
Brandt J,
Sieper J,
et al.
Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes. Ann Rheum Dis 2007;66:910–5.
OpenUrl Abstract/FREE Full Text

[28] Baraliakos X,

[29] Listing J,

[30] Rudwaleit M,

[31] Haibel H,

[32] Brandt J,

[33] Sieper J,

[34] et al.

[35] 6.↵
Baraliakos X,
Listing J,
Rudwaleit M,
Sieper J,
Braun J
. The relationship between inflammation and new bone formation in patients with ankylosing spondylitis. Arthritis Res Ther 2008;10:R104.
OpenUrl CrossRef PubMed

[36] Baraliakos X,

[37] Listing J,

[38] Rudwaleit M,

[39] Sieper J,

[40] Braun J

[41] 7.↵
Baraliakos X,
Listing J,
Fritz C,
Haibel H,
Alten R,
Burmester GR,
et al.
Persistent clinical efficacy and safety of infliximab in ankylosing spondylitis after 8 years—early clinical response predicts long-term outcome. Rheumatology 2011;50:1690–9.
OpenUrl Abstract/FREE Full Text

[42] Baraliakos X,

[43] Listing J,

[44] Fritz C,

[45] Haibel H,

[46] Alten R,

[47] Burmester GR,

[48] et al.

[49] 8.↵
Baraliakos X,
Heldmann F,
Callhoff J,
Listing J,
Appelboom T,
Brandt J,
et al.
Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. Ann Rheum Dis 2014;73:1819–25.
OpenUrl Abstract/FREE Full Text

[50] Baraliakos X,

[51] Heldmann F,

[52] Callhoff J,

[53] Listing J,

[54] Appelboom T,

[55] Brandt J,

[56] et al.

[57] 9.↵
Buchbender C,
Sewerin P,
Mattes-György K,
Miese F,
Wittsack HJ,
Specker C,
et al.
Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression. Eur J Radiol 2013;82:374–9.
OpenUrl CrossRef PubMed

[58] Buchbender C,

[59] Sewerin P,

[60] Mattes-György K,

[61] Miese F,

[62] Wittsack HJ,

[63] Specker C,

[64] et al.

[65] 10.↵
Hawkins RA,
Choi Y,
Huang SC,
Hoh CK,
Dahlbom M,
Schiepers C,
et al.
Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med 1992;33:633–42.
OpenUrl Abstract/FREE Full Text

[66] Hawkins RA,

[67] Choi Y,

[68] Huang SC,

[69] Hoh CK,

[70] Dahlbom M,

[71] Schiepers C,

[72] et al.

[73] 11.↵
Fischer DR,
Pfirrmann CW,
Zubler V,
Stumpe KD,
Seifert B,
Strobel K,
et al.
High bone turnover assessed by 18F-fluoride PET/CT in the spine and sacroiliac joints of patients with ankylosing spondylitis: comparison with inflammatory lesions detected by whole body MRI. EJNMMI Res 2012;2:38.
OpenUrl CrossRef PubMed

[74] Fischer DR,

[75] Pfirrmann CW,

[76] Zubler V,

[77] Stumpe KD,

[78] Seifert B,

[79] Strobel K,

[80] et al.

[81] 12.↵
Bruijnen ST,
van der Weijden MA,
Klein JP,
Hoekstra OS,
Boellaard R,
van Denderen JC,
et al.
Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study. Arthritis Res Ther 2012;14:R71.
OpenUrl CrossRef PubMed

[82] Bruijnen ST,

[83] van der Weijden MA,

[84] Klein JP,

[85] Hoekstra OS,

[86] Boellaard R,

[87] van Denderen JC,

[88] et al.

[89] 13.↵
van der Linden S,
Valkenburg HA,
Cats A
. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361–8.
OpenUrl CrossRef PubMed

[90] van der Linden S,

[91] Valkenburg HA,

[92] Cats A

[93] 14.↵
Garrett S,
Jenkinson T,
Kennedy LG,
Whitelock H,
Gaisford P,
Calin A
. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994;21:2286–91.
OpenUrl PubMed

[94] Garrett S,

[95] Jenkinson T,

[96] Kennedy LG,

[97] Whitelock H,

[98] Gaisford P,

[99] Calin A

[100] 15.↵
Baraliakos X,
Listing J,
von der Recke A,
Braun J
. The natural course of radiographic progression in ankylosing spondylitis—evidence for major individual variations in a large proportion of patients. J Rheumatol 2009;36:997–1002.
OpenUrl Abstract/FREE Full Text

[101] Baraliakos X,

[102] Listing J,

[103] von der Recke A,

[104] Braun J

[105] 16.↵
Buchbender C,
Heusner TA,
Lauenstein TC,
Bockisch A,
Antoch G
. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis. J Nucl Med 2012;53:928–38.
OpenUrl Abstract/FREE Full Text

[106] Buchbender C,

[107] Heusner TA,

[108] Lauenstein TC,

[109] Bockisch A,

[110] Antoch G

[111] 17.↵
Buchbender C,
Schneider M,
Ostendorf B
. [Magnetic resonance tomography and hybrid imaging in rheumatology]. [Article in German] Z Rheumatol 2013;72:137–44.
OpenUrl CrossRef PubMed

[112] Buchbender C,

[113] Schneider M,

[114] Ostendorf B

[115] 18.↵
Weber U,
Lambert RG,
Pedersen SJ,
Hodler J,
Ostergaard M,
Maksymowych WP
. Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis. Arthritis Care Res 2010;62:1763–71.
OpenUrl PubMed

[116] Weber U,

[117] Lambert RG,

[118] Pedersen SJ,

[119] Hodler J,

[120] Ostergaard M,

[121] Maksymowych WP

[122] 19.↵
Wick MC,
Weiss RJ,
Jaschke W,
Klauser AS
. Erosions are the most relevant magnetic resonance imaging features in quantification of sacroiliac joints in ankylosing spondylitis. J Rheumatol 2010;37:622–7.
OpenUrl Abstract/FREE Full Text

[123] Wick MC,

[124] Weiss RJ,

[125] Jaschke W,

[126] Klauser AS

[127] 20.↵
Sieper J,
Rudwaleit M,
Baraliakos X,
Brandt J,
Braun J,
Burgos-Vargas R,
et al.
The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 2009;68 Suppl 2:ii1–44.
OpenUrl Abstract/FREE Full Text

[128] Sieper J,

[129] Rudwaleit M,

[130] Baraliakos X,

[131] Brandt J,

[132] Braun J,

[133] Burgos-Vargas R,

[134] et al.

[135] 21.↵
van der Heijde D,
Sieper J,
Maksymowych WP,
Brown MA,
Lambert RG,
Rathmann SS,
et al.
Spinal inflammation in the absence of sacroiliac joint inflammation on magnetic resonance imaging in patients with active nonradiographic axial spondyloarthritis. Arthritis Rheumatol 2014;66:667–73.
OpenUrl CrossRef PubMed

[136] van der Heijde D,

[137] Sieper J,

[138] Maksymowych WP,

[139] Brown MA,

[140] Lambert RG,

[141] Rathmann SS,

[142] et al.

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Hybrid 18F-labeled Fluoride Positron Emission Tomography/Magnetic Resonance (MR) Imaging of the Sacroiliac Joints and the Spine in Patients with Axial Spondyloarthritis: A Pilot Study Exploring the Link of MR Bone Pathologies and Increased Osteoblastic Activity

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Hybrid 18F-labeled Fluoride Positron Emission Tomography/Magnetic Resonance (MR) Imaging of the Sacroiliac Joints and the Spine in Patients with Axial Spondyloarthritis: A Pilot Study Exploring the Link of MR Bone Pathologies and Increased Osteoblastic Activity

REFERENCES

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