Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
LetterCorrespondence

Evaluation of Leptin with Atherosclerosis in Rheumatoid Arthritis

MEHMET AGILLI, FEVZI NURI AYDIN, YASEMIN GULCAN KURT and TUNCER CAYCI
The Journal of Rheumatology April 2015, 42 (4) 727; DOI: https://doi.org/10.3899/jrheum.141395
MEHMET AGILLI
Department of Biochemistry, Agri Military Hospital, Agri;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mehmetagilli@yahoo.com
FEVZI NURI AYDIN
Department of Biochemistry, Sirnak Military Hospital, Sirnak;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YASEMIN GULCAN KURT
Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
Roles: Associate Professor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TUNCER CAYCI
Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
Roles: Associate Professor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

To the Editor:

We have read with great interest the letter by Dessein, et al, “Effect of traditional cardiovascular risk factors on the independent relationship of leptin with atherosclerosis in rheumatoid arthritis.1” They reported that they found an effect of leptin on carotid artery plaque that is dependent on the number of major conventional risk factors. However, we think there are some points that should be mentioned as contributory factors.

Leptin is an adipokine that regulates appetite and energy expenditure, as the authors stated. Previous studies suggested that several diseases such as major depression, chronic liver diseases, and several inflammatory diseases such as systemic lupus erythematosus, psoriasis, multiple sclerosis, and Helicobacter pylori infection could affect serum leptin levels2,3. The authors listed diabetes, hypertension, dyslipidemia, and smoking as major risk factors, which are also known as factors affecting serum leptin levels, but the diseases we mentioned have to be denoted to obtain a strong study group.

It was shown that some types of glucocorticoids, antihypertensive drugs, antipsychotics, and lipid-lowering, hormonal, insulin-sensitizing and antidepressant medications had an effect on serum leptin levels4,5. In addition to these medications, dietary food supplements such as vitamin A, vitamin D, vitamin E, zinc, linoleic acid, and omega-3 fatty acid could affect plasma leptin levels6. In this respect, the authors should define whether the participants use these kinds of drugs and dietary supplements.

Addressing these concerns will certainly provide a clearer picture when interpreting leptin levels among participants.

REFERENCES

  1. 1.↵
    1. Dessein PH,
    2. Tsang L,
    3. Woodiwiss AJ,
    4. Solomon A
    . Effect of traditional cardiovascular risk factors on the independent relationship of leptin with atherosclerosis in rheumatoid arthritis. J Rheumatol 2014;41:2087–9.
    OpenUrlFREE Full Text
  2. 2.↵
    1. Fantuzzi G,
    2. Faggioni R
    . Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000;68:437–46.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Park HK,
    2. Ahima RS
    . Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 2015;64:24–34.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Atmaca M,
    2. Kuloglu M,
    3. Tezcan E,
    4. Ustundag B,
    5. Semercioz A
    . Serum leptin levels in patients with premature ejaculation before and after citalopram treatment. BJU Int 2003;91:252–4.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Kraus T,
    2. Haack M,
    3. Schuld A,
    4. Hinze-Selch D,
    5. Kuhn M,
    6. Uhr M,
    7. et al.
    Body weight and leptin plasma levels during treatment with antipsychotic drugs. Am J Psychiatry 1999;156:312–4.
    OpenUrlPubMed
  6. 6.↵
    1. Xiong RB,
    2. Li Q,
    3. Wan WR,
    4. Guo JQ,
    5. Luo BD,
    6. Gan L
    . Effects and mechanisms of vitamin A and vitamin E on the levels of serum leptin and other related cytokines in rats with rheumatoid arthritis. Exp Ther Med 2014;8:499–504.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 42, Issue 4
1 Apr 2015
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Evaluation of Leptin with Atherosclerosis in Rheumatoid Arthritis
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Evaluation of Leptin with Atherosclerosis in Rheumatoid Arthritis
MEHMET AGILLI, FEVZI NURI AYDIN, YASEMIN GULCAN KURT, TUNCER CAYCI
The Journal of Rheumatology Apr 2015, 42 (4) 727; DOI: 10.3899/jrheum.141395

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Evaluation of Leptin with Atherosclerosis in Rheumatoid Arthritis
MEHMET AGILLI, FEVZI NURI AYDIN, YASEMIN GULCAN KURT, TUNCER CAYCI
The Journal of Rheumatology Apr 2015, 42 (4) 727; DOI: 10.3899/jrheum.141395
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • REFERENCES
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Post SARS-CoV-2 Vaccine Chilblains-like Lesions
  • A Case of Scleromyxedema Development Following Intravesical Bacillus Calmette-Guérin Administration
  • Dr. Li et al reply
Show more Correspondence

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire