Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • 50th Volume Reprints
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • 50th Volume Reprints
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow Jrheum on BlueSky
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
EditorialEditorial

Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis

HEINER APPEL and JOACHIM SIEPER
The Journal of Rheumatology April 2015, 42 (4) 561-563; DOI: https://doi.org/10.3899/jrheum.150046
HEINER APPEL
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Rheumatology, Berlin, Germany.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: heiner.appel{at}charite.de
JOACHIM SIEPER
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Rheumatology, Berlin, Germany.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
PreviousNext
Loading

REFERENCES

  1. 1.↵
    1. Braun J,
    2. Sieper J
    . Ankylosing spondylitis. Lancet 2007;369:1379–90.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Cruickshank B
    . Pathology of ankylosing spondylitis. Clin Orthop Relat Res 1971;74:43–58.
    OpenUrlPubMed
  3. 3.↵
    1. Clinicopathological conference
    .A case of early ankylosing spondylitis with fatal secondary amyloidosis. Br Med J 1968;2:412–6.
    OpenUrlFREE Full Text
  4. 4.↵
    1. Appel H,
    2. Kuhne M,
    3. Spiekermann S,
    4. Köhler D,
    5. Zacher J,
    6. Stein H,
    7. et al.
    Immunohistochemical analysis of hip arthritis in ankylosing spondylitis — an analysis of the bone/cartilage interface and subchondral bone marrow. Arthritis Rheum 2006;54:1805–13.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Braun J,
    2. Bollow M,
    3. Neure L,
    4. Seipelt E,
    5. Seyrekbasan F,
    6. Herbst H,
    7. et al.
    Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum 1995;38:499–505.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Francois RJ,
    2. Gardner DL,
    3. Degrave EJ,
    4. Bywaters EG
    . Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis. Arthritis Rheum 2000;43:2011–24.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Savill DL
    . The manubrio-sternal joint in ankylosing spondylitis. J Bone Joint Surg Br 1951;33:56–64.
    OpenUrlPubMed
  8. 8.↵
    1. Appel H,
    2. Kuhne M,
    3. Spiekermann S,
    4. Ebhardt H,
    5. Groszdanovic Z,
    6. Köhler D,
    7. et al.
    Immunohistological analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum 2006;54:2845–51.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Appel H,
    2. Maier R,
    3. Bleil J,
    4. Hempfing A,
    5. Loddenkemper C,
    6. Schlichting U,
    7. et al.
    In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum 2013;65:1522–9.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Bleil J,
    2. Maier R,
    3. Hempfing A,
    4. Schlichting U,
    5. Appel H,
    6. Sieper J,
    7. et al.
    Histomorphologic and histomorphometric characteristics of zygapophyseal joint remodeling in ankylosing spondylitis. Arthritis Rheumatol 2014;66:1745–54.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Appel H,
    2. Maier R,
    3. Wu P,
    4. Scheer R,
    5. Hempfing A,
    6. Kayser R,
    7. et al.
    Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 2011;13:R95.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Lories RJ,
    2. Luyten FP,
    3. de Vlam K
    . Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis. Arthritis Res Ther 2009;11:221.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Braem K,
    2. Deroose CM,
    3. Luyten FP,
    4. Lories RJ
    . Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis. Arthritis Res Ther 2012;14:R59.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Appel H,
    2. Sieper J
    . Spondyloarthritis at the crossroads of imaging, pathology, and structural damage in the era of biologics. Curr Rheumatol Rep 2008;10:356–63.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Pacheco-Tena C,
    2. Pérez-Tamayo R,
    3. Pineda C,
    4. González-Chávez SA,
    5. Quiñonez-Flores C,
    6. Vitelly AU,
    7. et al.
    Bone lineage proteins in the entheses of the midfoot in patients with spondyloarthritis. J Rheumatol 2015:630–7.
  16. 16.↵
    1. Baraliakos X,
    2. Heldmann F,
    3. Callhoff J,
    4. Listing J,
    5. Appelboom T,
    6. Brandt J,
    7. et al.
    Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. Ann Rheum Dis 2014;73:1819–25.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Pedersen SJ,
    2. Chiowchanwisawakit P,
    3. Lambert RG,
    4. Østergaard M,
    5. Maksymowych WP
    . Resolution of inflammation following treatment of ankylosing spondylitis is associated with new bone formation. J Rheumatol 2011;38:1349–54.
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Maksymowych WP,
    2. Chiowchanwisawakit P,
    3. Clare T,
    4. Pedersen SJ,
    5. Østergaard M,
    6. Lambert RG
    . Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: evidence of a relationship between inflammation and new bone formation. Arthritis Rheum 2009;60:93–102.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Lories RJ,
    2. Matthys P,
    3. de Vlam K,
    4. Derese I,
    5. Luyten FP
    . Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis. Ann Rheum Dis 2004;63:595–8.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Jacques P,
    2. Lambrecht S,
    3. Verheugen E,
    4. Pauwels E,
    5. Kollias G,
    6. Armaka M,
    7. et al.
    Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann Rheum Dis 2014;73:437–45.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Gong Y,
    2. Zheng N,
    3. Chen SB,
    4. Xiao ZY,
    5. Wu MY,
    6. Liu Y,
    7. et al.
    Ten years’ experience with needle biopsy in the early diagnosis of sacroiliitis. Arthritis Rheum 2012;64:1399–406.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 42, Issue 4
1 Apr 2015
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis
HEINER APPEL, JOACHIM SIEPER
The Journal of Rheumatology Apr 2015, 42 (4) 561-563; DOI: 10.3899/jrheum.150046

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Analysis of Bone Samples from Patients with Spondyloarthritides—Identifying Causes of New Bone Formation in Axial Spondyloarthritis
HEINER APPEL, JOACHIM SIEPER
The Journal of Rheumatology Apr 2015, 42 (4) 561-563; DOI: 10.3899/jrheum.150046
del.icio.us logo Twitter logo Facebook logo  logo Mendeley logo
  • Tweet Widget
  •  logo
Bookmark this article

Jump to section

  • Article
    • REFERENCES
  • Info & Metrics
  • References
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Defining Enthesitis on Ultrasound in Spondyloarthritis: Lessons From the DEUS Initiative and the Path Forward
  • What Predicts Initial Biologic Disease-Modifying Antirheumatic Drug Failure in Psoriatic Arthritis and How Common Is It?
  • Sjögren Disease: Does an Accurate Diagnosis Matter?
Show more Editorial

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2025 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire