Article Figures & Data
Figures
- Figure 1.
Patterns of cumulative joint damage (CJD). Panels A and B: sets of radiographs from distinct patients with hand-dominant (A) and foot-dominant (B) CJD pattern. Panel C: radiographs from distinct patients with wrist-dominant (left) and finger-dominant (right) CJD patterns. Panel D: erosion-dominant (left) and space narrowing–dominant (right) CJD pattern. Filled single arrows: erosion sites; double arrows: space-narrowing sites; unfilled single arrows: preserved sites.
- Figure 2.
Distribution of patients with rheumatoid arthritis (RA) according to total Sharp-van der Heijde (SvdH) score and disease duration. The thin line represents the central trend of SvdH score progress over the years based on the total cohort of patients, and the thick continuous and dashed lines represent the upper and lower interval boundaries, respectively. This interval corresponds to 95% probability for the distribution of the central trend line in this cohort of patients. Dots scattered above the thick continuous line represent patients who were considered to have severe RA and those scattered below the thick dashed line represent patients who were considered to have mild RA.
- Figure 3.
Distribution of rheumatoid arthritis patients according to (A) hand/foot score, (B) finger/wrist score, and (C) erosion/space-narrowing score. Imbalanced patterns of cumulative joint damage were defined as those areas below the 30th and above the 70th percentile distribution of derivative Sharp-van der Heijde scores, respectively. *Intervals between dashed vertical lines correspond to balanced patterns of cumulative joint damage (≥ 30th and ≤ 70th percentile).
Tables
- Table 1.
Demographic, clinical, and laboratory characteristics of rheumatoid arthritis patients. Unless otherwise stated, the number of patients analyzed was 404.
Characteristics Female sex 367 (90.8%) Age, yrs, median ± SD 53.18 ± 11.59; range 18–89 Ethnicity, n = 393, n (%) European-derived 174 (44.3) Mulatto 167 (42.5) African-derived 48 (12.2) Asian-derived 4 (1.0) Disease duration, yrs, median ± SD 11.16 ± 7.78; range 2–48 Functional class, n = 377, n (%) Functional class I, 164 (43.5) Functional class II 138 (36.6) Functional class III 60 (15.9) Functional class IV 15 (4.0 ) Health Assessment Questionnaire score, n = 396, median ± SD 0.65 ± 0.59; range 0–2.38 Presence of extraarticular manifestations, n = 363 115 (31.7%) Drugs Methotrexate 295 (73.0%) Prednisone 244 (60.4%) Antimalarials 128 (31.7%) Leflunomide 119 (29.5%) Sulfasalazine 38 (9.4%) Immunobiologicals 21 (5.2%) RF-positive ≥ 20 IU/ml, n = 390 248 (61.4%) ACPA-positive > 20 U/ml, n = 390 307 (76.0%) Height, meters, median ± SD 1.58 ± 0.07; range 1.34–1.83 Body mass index, n = 272, mean ± SD 26.70 ± 4.60; range 16.65–41.66 Total Sharp score, mean ± SD 109.7 ± 74.8; range 0–379 -
RF: rheumatoid factor; ACPA: anticitrullinated peptide antibody.
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- Table 2.
Frequency of HLA-DRB1 shared epitope (SE) alleles in the total number of patients (291) with mild and severe rheumatoid arthritis (RA).
Patients with Mild RA, n = 146 Patients with Severe RA, n = 145 p Allele Frequency SE Alleles DRB1*0101 0.082 0.059 0.275 DRB1*0102 0.062 0.041 DRB1*0401 0.041 0.045 DRB1*0404 0.051 0.048 DRB1*0405 0.051 0.079 DRB1*0408 0.01 0.031 DRB1*0410 0.01 0 DRB1*1001 0.034 0.024 DRB1*1402 0.017 0.024 Frequency of patients carrying SE alleles Any SE 58.9% 60.7% 0.756 Single SE 45.9% 51.0% 0.555 Double SE 13.0% 9.7% - Table 3.
Association between patterns of cumulative joint damage (CJD) and the presence of DRB1 shared epitope (SE) alleles in patients with rheumatoid arthritis.
Hand/foot Imbalance, n = 138 p Finger/wrist Imbalance, n = 145 p Erosion/space-narrowing Imbalance, n = 140 p HLA-DRB1 Hands, n = 68, n (%) Feet, n = 70, n (%) Fingers, n = 72, n (%) Wrists, n = 73, n (%) Erosion, n = 70, n (%) Space narrowing, n = 70, n (%) SE Positive 43 (46.2) 50 (53.8) 0.305 49 (51.0) 47 (49.0) 0.640 52 (57.1) 39 (42.9) 0.021 Negative 25 (55.6) 20 (44.4) 23 (46.9) 26 (53.1) 18 (36.7) 31 (63.3) SE dose Single 37 (47.4) 41 (52.6) 0.597 40 (50.0) 40 (50.0) 0.648 42 (56.8) 32 (43.2) 0.877 Double 6 (40.0) 9 (60.0) 9 (56.3) 7 (46.8) 10 (58.8) 7 (41.2) -
Significant p value is given in bold face. Hand-dominant (h/f score > 3.74); foot-dominant (h/f score < 1.69); finger-dominant (f/w score > 1.92); wrist-dominant (f/w score < 0.93); erosion-dominant (e/sn score > 2.38); space narrowing–dominant (e/sn score < 1.58).
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