Article Figures & Data
Figures
- Figure 1.
Prevalence and mean scores of JSN (status and change), per individual joint space. The prevalence of patients with a score > 0 at baseline (A) and for change scores (B) is shown at each individual joint site. Mean scores at baseline and followup (C) and for change scores (D) are means of the 8 reads (2 reads by each of the 4 readers). JSN: joint space narrowing; CMC: carpometacarpal; TRM: trapezium; TRD: trapezoid; CAP: capitate; HAM: hamate; SCA: scaphoid; LUN: lunate; TRI: triquetrum; RAD: radius.
Tables
- Table 1.
Baseline characteristics of the 20 patients with rheumatoid arthritis included in the exercise.
Female, n (%) 15 (75) Age, yrs, median (25th and 75th percentile) 55 (41;63) Disease duration, days, median (25th and 75th percentile) 87 (36;136) IgM RF positivity, n (%) 9 (45) Anti-CCP positivity, n (%) 12 (60) DAS28, median (25th and 75th percentile) 3.78 (3.30;4.72) ESR, mm/h, median (25th and 75th percentile) 12 (10;21) 28-joint swollen joint count, median (25th and 75th percentile) 5.5 (4;10) IgM RF: immunoglobulin M rheumatoid factor; CCP: cyclic citrullinated protein; DAS: Disease Activity Score; ESR: erythrocyte sedimentation rate.
- Table 2.
Intrareader and interreader intraclass correlation coefficients (ICC) and smallest detectable change (SDC).
Intrareader Interreader Reader 1 Reader 2 Reader 3 Reader 4 ICC Baseline total score (95% CI) 0.89 (0.69 to 0.96) 0.79 (0.51 to 0.91) 0.52 (0.11 to 0.78) 0.96 (0.90 to 0.98) 0.36 (−0.03 to 0.68) Total change score (95% CI) 0.41 (−0.02 to 0.72) 0.93 (0.83 to 0.97) 0.93 (0.83 to 0.97) 0.95 (0.87 to 0.98) 0.93 (0.87 to 0.97) SDC (percentage of maximum score observed) Total score 6.75 (0.31) 2.56 (0.14) 2.34 (0.09) 3.18 (0.12) 2.88 (0.03) CMC1 0.30 (0.15) 0.31 (0.15) 0.57 (0.38) 0.51 (0.34) 0.36 (0.05) CMC2 0.31 (0.31) 0.31 (0.31) 0.68 (0.34) 0.55 (0.36) 0.29 (0.05) CMC3 0.43 (0.21) 0.51 (0.34) 0.45 (0.30) 0.62 (0.41) 0.35 (0.05) CMC4 0.62 (0.41) 0.68 (0.68) 0.93 (0.93) 0.57 (0.38) 0.26 (0.05) CMC5 0.62 (1.24) 0.31 (0.31) 0.00 (NP*) 0.68 (0.68) 0.26 (0.11) TRM-TRD 0.43 (0.85) 0.00 (NP*) 0.00 (NP*) 0.00 (NP*) 0.08 (0.15) TRD-CAP 0.73 (0.73) 0.84 (0.56) 0.76 (0.51) 0.43 (0.43) 0.33 (0.07) CAP-HAM 0.31 (0.15) 0.62 (0.62) 0.62 (0.25) 0.43 (0.28) 0.32 (0.05) TRM-SCA 0.77 (0.51) 0.55 (0.27) 0.55 (0.22) 0.78 (0.31) 0.49 (0.06) TRD-SCA 0.62 (0.62) 0.73 (0.48) 0.31 (0.21) 0.55 (0.55) 0.30 (0.06) CAP-SCA 0.55 (0.27) 0.31 (0.21) 0.43 (0.21) 0.51 (0.17) 0.39 (0.05) CAP-LUN 0.43 (0.21) 0.31 (0.15) 0.71 (0.35) 0.45 (0.22) 0.33 (0.04) HAM-TRI 0.00 (0.00) 0.62 (0.41) 0.51 (0.20) 0.68 (0.27) 0.32 (0.04) SCA-LUN 0.71 (0.28) 0.31 (0.15) 0.62 (0.21) 0.62 (0.25) 0.26 (0.03) LUN-TRI 0.43 (0.21) 0.55 (0.27) 0.62 (0.21) 0.55 (0.22) 0.45 (0.05) RAD-SCA 0.89 (0.89) 0.55 (0.55) 0.31 (0.31) 0.31 (0.15) 0.31 (0.06) RAD-LUN 0.64 (0.32) 0.64 (0.25) 0.43 (0.17) 0.45 (0.15) 0.27 (0.03) ↵* NP: Not possible to calculate because of zero variance. Intrareader agreement is expressed as single measure ICC and interreader agreement as average measure ICC with a 95% CI. An ICC ≥ 0.50 is considered good and an ICC ≥ 0.80 is considered very good. SDC is calculated for intrareader and interreader change scores and is also expressed as the percentage of the maximal score observed by the reader. Interreader agreement is calculated by using the mean score of the 2 readings performed by each reader on a single timepoint. CMC: carpometacarpal; TRM: trapezium; TRD: trapezoid; CAP: capitate; HAM: hamate; SCA: scaphoid; LUN: lunate; TRI: triquetrum; RAD: radius.
- Table 3.
Percentage of exact agreement (PEA) and close agreement (PCA) for JSN assessment in each individual joint space.
Intrareader Baseline Intrareader Change Interreader Baseline Interreader Change Mean PEA Mean PCA Mean PEA Mean PCA PEA PCA PEA PCA CMC1 73.8 100.0 87.5 100.0 5.0 75.0 45.0 100.0 CMC2 77.5 100.0 92.5 98.8 0.0 40.0 55.0 100.0 CMC3 66.3 95.0 88.8 100.0 0.0 60.0 50.0 85.0 CMC4 52.5 96.3 76.3 96.3 0.0 75.0 55.0 95.0 CMC5 61.3 100.0 93.8 100.0 5.0 70.0 55.0 100.0 TRM-TRD 92.5 97.5 97.5 100.0 65.0 100.0 90.0 100.0 TRD-CAP 58.8 91.3 70.0 98.8 15.0 50.0 35.0 95.0 CAP-HAM 60.8 98.7 87.3 98.7 0.0 50.0 60.0 95.0 TRM-SCA 73.8 100.0 81.3 100.0 15.0 60.0 30.0 70.0 TRD-SCA 70.0 95.0 84.8 100.0 0.0 45.0 35.0 90.0 CAP-SCA 78.8 100.0 90.0 100.0 10.0 85.0 55.0 85.0 CAP-LUN 80.0 100.0 91.3 97.5 5.0 80.0 60.0 95.0 HAM-TRI 79.7 100.0 87.3 100.0 20.0 85.0 60.0 90.0 SCA-LUN 82.5 100.0 90.0 97.5 45.0 95.0 45.0 100.0 LUN-TRI 73.8 100.0 83.8 100.0 15.0 75.0 40.0 75.0 RAD-SCA 77.5 100.0 87.5 98.8 15.0 85.0 45.0 100.0 RAD-LUN 82.5 100.0 85.0 100.0 30.0 90.0 60.0 95.0 All joints (mean) 74.1 96.0 86.7 99.2 14.4 71.8 51.5 92.4 Intrareader percentage of exact agreement (PEA) expresses the percentage of the patients receiving the same score twice by a single reader, and intrareader percentage of close agreement (PCA) is the percentage of the patients where the 2 readings differ no more than 1.0 in score. Intrareader PEA and PCA are presented as the mean of the 4 readers. Interreader PEA expresses the percentage of the patients receiving the same score by all 4 readers, and the interreader PCA is the percentage of the patients where the difference between the minimum and maximum score is ≤ 1.0. CMC: carpometacarpal; TRM: trapezium; TRD: trapezoid; CAP: capitate; HAM: hamate; SCA: scaphoid; LUN: lunate; TRI: triquetrum; RAD: radius.
