Article Figures & Data
Figures
- Figure 1.
Score distributions for PASDAS in GRACE study. The “change” group had its treatment changed or escalated for “active” disease. The “no change” group did not have treatment change and was therefore deemed to be in stable disease activity. The broken lines represent the 50th percentile values. PASDAS: Psoriatic ArthritiS Disease Activity Score; GRACE: GRAppa Composite scorE (index).
- Figure 2.
Receiver-operating curve (ROC) for PASDAS with decision to change treatment as discriminator. The value of PASDAS at 90% specificity was 5.62 (at this point sensitivity was 40%, as indicated by the dotted line). Area under the curve was 0.78 (95% CI: 0.75–0.81). PASDAS: Psoriatic ArthritiS Disease Activity Score.
Tables
- Table 1.
Cutoffs for disease activity for PASDAS using physician and patient global scores.
Score Cutoff Low (sens, spec) Moderate (sens, spec) High (sens, spec) Physician global 3.59 (73.2, 90.2) 4.44 (83.6, 90.0) 5.65 (80.8, 90.0) Patient global 2.67 (84.4, 90.2) 3.67 (81.3, 90.0) 5.07 (71.1, 90.0) -
PASDAS: Psoriatic ArthritiS Disease Activity Score; Low: cutoff between low and moderate disease activity; Moderate: cutoff between moderate and high disease activity; High: cutoff between high and very high disease activity; sens, spec: sensitivity, specificity.
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Measure Score Distribution 50th Percentile ROC VAS Global Mean* Column No. 1 2 3 4 5 PASDAS Low 3.7 N/A 2.7 3.2 Mod N/A N/A 3.7 N/A High 5.5 5.6 5.1 5.4 GRACE Low 3.0 N/A 1.6 2.3 Mod N/A N/A 2.9 N/A High 4.6 5.2 4.3 4.7 CPDAI Low 4 N/A 4 4 Mod N/A N/A 6 N/A High 7 8 8 8 DAS28-CRP Low 2.8 N/A 2.7 2.8 Mod N/A N/A 3.3 N/A High 3.9 4.7 4.1 4.2 DAPSA Low 18.5 N/A 18.5 18.5 Mod N/A N/A 31.2 N/A High 33.1 55.2 47.0 45.1 -
↵* Mean of estimates (50th percentile, ROC, and VAS global). CPDAI: Composite Psoriatic Disease Activity Index; DAPSA: Disease Activity score for PSoriatic Arthritis; DAS28-CRP: Disease Activity Score for 28 joints–C-reactive protein; GRACE: GRAPPA Composite Exercise; GRAPPA: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis; N/A: not available; PASDAS: Psoriatic ArthritiS Disease Activity Score; ROC: receiver-operating curve; VAS: visual analog score.
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Percentile Measure 5 10 25 50 75 90 95 PASDAS No change 1.30 1.70 2.67 3.66 4.91 6.10 6.51 Change 2.96 3.61 4.49 5.45 6.19 6.89 7.14 GRACE No change 0.57 0.78 1.54 2.95 4.32 5.41 6.26 Change 1.20 2.23 3.42 4.57 5.68 6.60 7.16 CPDAI No change 1.00 2.00 3.00 4.00 7.00 9.00 10.00 Change 2.00 3.00 5.00 7.00 9.00 10.00 11.00 DAS28-CRP No change 1.34 1.50 1.94 2.83 3.74 4.98 5.72 Change 1.82 2.16 3.09 3.88 4.76 5.57 5.70 DAPSA No change 2.80 4.55 9.48 18.45 32.83 60.75 107.60 Change 7.01 14.40 22.30 33.10 55.25 72.27 105.81 -
CPDAI: Composite Psoriatic Disease Activity Index; DAPSA: Disease Activity score for PSoriatic Arthritis; DAS28-CRP: Disease Activity Score for 28 joints–C-reactive protein; GRACE: GRAPPA Composite Exercise; GRAPPA: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis; PASDAS: Psoriatic ArthritiS Disease Activity Score.
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Measure ro SD e R2 PASDAS 0.826 1.69 0.776 0.734 GRACE 0.782 1.88 0.989 0.459 CPDAI 0.692 2.78 1.853 0.533 DAS28-CRP 0.755 1.34 0.763 0.660 DAPSA 0.827 31.08 14.215 0.892 -
ro: derived from the regression equation of the interperiod correlation coefficients and represents the correlation at time zero; SD: standard deviation of ro; e: measurement error; R2: measure of goodness of fit of regression equation; CPDAI: Composite Psoriatic Disease Activity Index; DAPSA: Disease Activity score for PSoriatic Arthritis; DAS28-CRP: Disease Activity Score for 28 joints–C-reactive protein; GRACE: GRAPPA Composite Exercise; GRAPPA: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis; PASDAS: Psoriatic ArthritiS Disease Activity Score.
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Final PASDAS Score Improvement > 1.6 < 1.6 but > 0.8 < 0.8 ≤ 3.2 1 2 3 > 3.2 but < 5.4 2 2 3 ≥ 5.4 2 3 3 -
1: good response; 2: moderate response; 3: poor response.
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Final GRACE Score Improvement > 2.0 < 2.0 but > 1.0 < 1.0 ≤ 2.3 1 2 3 > 2.3 but < 4.7 2 2 3 ≥ 4.7 2 3 3 -
1: good response; 2: moderate response; 3: poor response.
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Final CPDAI Score Improvement > 4.0 < 4.0 but > 2.0 < 2.0 ≤ 4.0 1 2 3 > 4.0 but < 8.0 2 2 3 ≥ 8.0 2 3 3 -
1: good response; 2: moderate response; 3: poor response.
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Final DAS28-CRP Score Improvement > 1.6 < 1.6 but > 0.8 < 0.8 ≤ 2.8 1 2 3 > 2.8 but < 4.2 2 2 3 ≥ 4.2 2 3 3 -
1: good response; 2: moderate response; 3: poor response. CRP: C-reactive protein.
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Final DAPSA Score Improvement > 28.4 < 28.4 but > 14.2 < 14.2 ≤ 18.5 1 2 3 > 18.5 but < 45.1 2 2 3 ≥ 45.1 2 3 3 -
1: good response; 2: moderate response; 3: poor response.
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