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Research ArticleArticle

Systemic Autoimmune Rheumatic Disease Prevalence in Canada: Updated Analyses Across 7 Provinces

Laurel Broten, J. Antonio Aviña-Zubieta, Diane Lacaille, Lawrence Joseph, John G. Hanly, Lisa Lix, Siobhan O’Donnell, Cheryl Barnabe, Paul R. Fortin, Marie Hudson, Sonia Jean, Christine Peschken, Steven M. Edworthy, Larry Svenson, Christian A. Pineau, Ann E. Clarke, Mark Smith, Patrick Bélisle, Elizabeth M. Badley, Louise Bergeron and Sasha Bernatsky
The Journal of Rheumatology April 2014, 41 (4) 673-679; DOI: https://doi.org/10.3899/jrheum.130667
Laurel Broten
From the Division of Clinical Epidemiology, and Divisions of Rheumatology, and Clinical Immunology/Allergy, Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec; Division of Rheumatology, University of British Columbia, Vancouver, British Columbia; Department of Epidemiology and Biostatistics, and Division of Rheumatology, McGill University; Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia; Departments of Medicine and Community Health Sciences, University of Manitoba, and Repository, Manitoba Centre for Health Policy, Winnipeg, Manitoba; Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, Ontario; Division of Rheumatology, University of Calgary, Calgary, Alberta; Centre de recherche du CHU de Québec, Faculté de médecine, Université Laval, Quebec City, Quebec; Chronic Disease Surveillance Division, National Institute of Public Health of Québec; Health Surveillance Branch, Public Health Division, Alberta Health and Wellness, Edmonton, Alberta; Divisions of Rheumatology, and Clinical Immunology/Allergy, Research Institute of the MUHC; Canadian Arthritis Patient Alliance; Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
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J. Antonio Aviña-Zubieta
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Diane Lacaille
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Lawrence Joseph
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John G. Hanly
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Lisa Lix
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Siobhan O’Donnell
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Cheryl Barnabe
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Paul R. Fortin
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Marie Hudson
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Sonia Jean
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Christine Peschken
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Steven M. Edworthy
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Larry Svenson
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Christian A. Pineau
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Ann E. Clarke
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Mark Smith
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Patrick Bélisle
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Elizabeth M. Badley
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Louise Bergeron
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Sasha Bernatsky
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  • For correspondence: sasha.bernatsky@mcgill.ca
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    Figure 1.

    Sensitivity of different systemic autoimmune rheumatic disease (SARD) case ascertainment methods (estimated from Bayesian hierarchical latent class models). Models estimated sensitivity for each of the 3 case definitions (rheumatology billing, 2-code physician billing, and hospital diagnosis), based on the total number of SARD cases identified from all sources, and accounting for error in each. Error bars represent Bayesian credible intervals (the values between which there is a 95% probability of containing the variable of interest, given the data and prior information input). Left panels, subjects age < 45 years; right panels, age ≥ 45 years.

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    Table 1.

    Systemic autoimmune rheumatic disease (SARD) prevalence estimates (Bayesian latent class hierarchical modeling): prevalence estimates (95% credible interval) per 1000 residents by age and rural/urban status, 7 Canadian provinces, 1988 to 2007.

    FemaleMale
    RuralUrbanRuralUrban
    A. Residents aged < 45 yrs
      Alberta1.8 (1.6–2.0)2.2 (2.0–2.4)0.2 (0.1–0.3)0.3 (0.2–0.4)
      British Columbia1.0 (0.8–1.2)4.5 (4.2–4.8)0.1 (0.1–0.2)0.6 (0.5–0.7)
      Manitoba2.1 (1.8–2.4)2.4 (2.1–2.7)0.2 (0.1–0.2)0.2 (0.1–0.3)
      Nova Scotia0.9 (0.6–1.4)1.1 (0.8–1.7)0.2 (0.1–0.3)0.2 (0.1–0.4)
      Ontario3.2 (3.0–3.4)4.3 (4.1–4.4)0.2 (0.2–0.3)0.3 (0.3–0.3)
      Quebec1.0 (0.9–1.1)2.0 (1.8–2.1)0.1 (0.1–0.2)0.2 (0.2–0.3)
      Saskatchewan2.3 (1.9–2.7)2.3 (1.9–2.8)0.2 (0.2–0.3)0.2 (0.2–0.3)
    B. Residents aged ≥ 45 yrs
      Alberta8.4 (7.8–9.1)9.0 (8.5–9.6)1.9 (1.6–2.3)1.7 (1.4–1.9)
      British Columbia4.9 (4.4–5.4)10.0 (9.9–10.0)0.5 (0.4–0.6)5.6 (5.2–6.1)
      Manitoba11.8 (10.9–12.7)13.2 (12.5–14.0)1.8 (1.5–2.3)2.0 (1.6–2.4)
      Nova Scotia6.6 (5.5–10.4)11.0 (9.1–16.7)1.6 (1.1–2.6)3.1 (2.3–4.8)
      Ontario13.6 (13.1–14.2)15.4 (15–15.7)3.5 (3.2–3.9)5.1 (4.8–5.5)
      Quebec5.7 (5.4–5.9)9.4 (9.1–9.8)1.4 (1.3–1.6)2.4 (2.1–2.6)
      Saskatchewan9.5 (8.8–9.9)9.9 (9.6–10.0)1.7 (1.3–2.3)1.8 (1.4–2.6)
    FemalesMalesTotal
    C. Overall prevalence
      Alberta4.5 (4.3–4.8)0.8 (0.7–0.9)2.7 (2.5–2.9)
      British Columbia6.1 (5.9–6.2)2.2 (2.1–2.4)4.2 (4.0–4.3)
      Manitoba6.5 (6.2–6.8)0.8 (0.7–0.9)3.8 (3.5–4.0)
      Nova Scotia4.2 (3.6–5.7)1.0 (0.8–1.4)2.6 (2.2–3.6)
      Ontario7.8 (7.6–8.0)2.2 (2.0–2.4)5.0 (4.8–5.2)
      Quebec4.2 (4.1–4.4)0.8 (0.8–0.9)2.5 (2.5–2.7)
      Saskatchewan5.5 (5.2–5.7)0.9 (0.7–1.1)3.2 (3.0–3.4)
    • Credible intervals represent the values between which there is a 95% probability of containing the variable of interest, given the data and prior information input.

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1 Apr 2014
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Systemic Autoimmune Rheumatic Disease Prevalence in Canada: Updated Analyses Across 7 Provinces
Laurel Broten, J. Antonio Aviña-Zubieta, Diane Lacaille, Lawrence Joseph, John G. Hanly, Lisa Lix, Siobhan O’Donnell, Cheryl Barnabe, Paul R. Fortin, Marie Hudson, Sonia Jean, Christine Peschken, Steven M. Edworthy, Larry Svenson, Christian A. Pineau, Ann E. Clarke, Mark Smith, Patrick Bélisle, Elizabeth M. Badley, Louise Bergeron, Sasha Bernatsky
The Journal of Rheumatology Apr 2014, 41 (4) 673-679; DOI: 10.3899/jrheum.130667

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Systemic Autoimmune Rheumatic Disease Prevalence in Canada: Updated Analyses Across 7 Provinces
Laurel Broten, J. Antonio Aviña-Zubieta, Diane Lacaille, Lawrence Joseph, John G. Hanly, Lisa Lix, Siobhan O’Donnell, Cheryl Barnabe, Paul R. Fortin, Marie Hudson, Sonia Jean, Christine Peschken, Steven M. Edworthy, Larry Svenson, Christian A. Pineau, Ann E. Clarke, Mark Smith, Patrick Bélisle, Elizabeth M. Badley, Louise Bergeron, Sasha Bernatsky
The Journal of Rheumatology Apr 2014, 41 (4) 673-679; DOI: 10.3899/jrheum.130667
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Keywords

PREVALENCE
AUTOIMMUNE DISEASES
RHEUMATIC DISEASES
SYSTEMIC SCLEROSIS
SYSTEMIC LUPUS ERYTHEMATOSUS

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