Article Figures & Data
Tables
- Table 1.
Clinical features of patients with dermatomyositis and controls. Data are mean ± SD unless otherwise indicated.
Clinical Features Patients, n = 51 Controls, n = 51 Age, yrs 44.06 ± 11.80 44.41 ± 10.60 Female, % 84.31 84.31 Duration, mos (range) 8 (0.3, 48) — DAS score (range) 10 (5, 17) — Muscle weakness, % 100 — Myalgia, % 28.41 — Polyarthralgia, % 35.29 — Heliotrope rash, % 64.71 — Gottron sign, % 60.78 — Shawl sign, % 17.65 — Raynaud phenomenon, % 7.84 — Lung involvement, % 52.94 0 Systolic BP, mmHg 117.61 ± 11.57 118.67 ± 10.03 Diastolic BP, mmHg 72.14 ± 12.93 74.76 ± 7.27 Heart rate, beats/min 81.35 ± 6.74 80.10 ± 4.13 Triglyceride, mmol/l 1.68 ± 0.77 1.36 ± 0.79* Total cholesterol, mmol/l 4.79 ± 1.23 4.77 ± 0.70 LDL cholesterol, mmol/l 2.85 ± 1.21 2.71 ± 0.66 HDL cholesterol, mmol/l 1.44 ± 0.45 1.54 ± 0.34 Serum uric acid, umol/l 306.49 ± 95.38 330.20 ± 93.52 Fasting plasma glucose, mmol/l 4.78 ± 0.79 4.84 ± 0.67 ANA-positive, % 84.31 0 Anti-Jo1 antibody-positive, % 9.80 0 Medications, % Glucocorticoid 94.11 0 Methotrexate 25.49 0 Azathioprine 3.92 0 Cyclophosphamide 21.57 0 Hydroxychloroquine 58.82 0 IVIG 0 0 Biologics 0 0 -
p < 0.05. DAS: Disease Activity Score; BP: blood pressure; LDL: low-density lipoprotein; HDL: high-density lipoprotein; IVIG: intravenous immunoglobulin; ANA: antinuclear antibody.
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- Table 2.
Echocardiographic and Doppler variables in patients with dermatomyositis and controls. Data are mean ± SD unless otherwise indicated.
Variable Patients, n = 51 Controls, n = 51 p Left ventricular (LV) diameter, mm 44.57 ± 4.36 45.24 ± 3.22 NS Left atrium diameter, mm 30.39 ± 3.72 29.51 ± 2.80 NS Interventricular septum thickness, mm (range) 9 (8, 10) 9 (8, 10) NS Posterior wall thickness, mm (range) 9 (8, 10) 9 (8, 9) NS Aortic root diameter, mm (range) 28 (26, 29) 27 (26, 28) NS Ascending aorta diameter, mm (range) 28 (27, 31) 27 (26, 28) NS Main pulmonary artery diameter, mm (range) 20 (19, 22) 18 (17, 20) NS LV end-diastolic dimension, mm (range) 45 (43, 47) 45 (43, 48) NS LV end-systolic dimension, mm (range) 28 (26, 30) 28 (27, 30) NS LV end-diastolic volume, ml (range) 92 (83, 104) 93 (83, 106) NS LV end-systolic volume, ml 30 (25, 34) 30 (26, 35) NS Peak of early diastolic flow velocity (E), m/s 0.72 ± 0.19 0.79 ± 0.16 NS Peak of late diastolic flow velocity (A), m/s 0.77 ± 0.18 0.67 ± 0.13 < 0.05 E/A ratio 0.97 ± 0.33 1.20 ± 0.28 < 0.001 Mitral annular early diastolic velocity (Em), cm/s 7.78 ± 2.90 9.32 ± 2.10 < 0.05 Mitral annular late diastolic velocity (Am), cm/s (range) 8 (7, 9) 7.3 (6.8, 9.2) NS Em/Am ratio (range) 0.89 (0.64, 1.22) 1.18 (1.04, 1.29) < 0.01 E/Em ratio 9.92 ± 2.82 8.67 ± 1.92 < 0.05 Deceleration time of flow velocity in early diastole (DT), ms 231.75 ± 40.60 208.20 ± 26.30 < 0.01 Isovolumic relaxation time, ms 81.06 ± 19.31 77.41 ± 11.32 NS LV stroke volume, ml 61.16 ± 12.21 65.35 ± 10.83 0.069 LV ejection fraction, % 66.45 ± 6.81 68.20 ± 4.11 0.120 LV fractional shortening, % (range) 38 (34, 40) 38 (36, 41) 0.284 -
NS: not significant (p > 0.05).
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- Table 3.
Correlation of left ventricular diastolic function variables and duration/DAS score in patients with dermatomyositis (DM).
Variables DM Duration DAS r p r p Peak of early diastolic flow velocity (E) −0.247 0.080 −0.180 0.206 Peak of late diastolic flow velocity (A) 0.373 0.007 0.003 0.981 E/A ratio −0.467 0.001 −0.229 0.106 Mitral annular early diastolic velocity (Em) −0.474 < 0.001 −0.122 0.395 Mitral annular late diastolic velocity (Am) 0.045 0.756 0.111 0.437 Em/Am ratio −0.476 < 0.001 −0.208 0.143 E/Em 0.320 0.022 0.009 0.950 DT of flow velocity in early diastole 0.474 < 0.001 0.213 0.133 Isovolumic relaxation time 0.261 0.065 0.222 0.117 -
DAS: Disease Activity Score; DT: deceleration time.
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B SE β t p Model 1 Constant 6.922 1.551 — 4.464 0.000 Age 0.046 0.034 0.193 1.345 0.185 Sex 0.448 1.071 0.058 0.418 0.678 Disease duration 0.091 0.041 0.318 2.246 0.029 Model 2 Constant 15.5 6.870 — 2.256 0.029 Age 0.055 0.037 0.231 1.489 0.144 Sex 0.885 1.133 0.115 0.782 0.439 Disease duration 0.131 0.051 0.457 2.575 0.014 DAS 0.041 0.146 0.042 0.280 0.780 Heart rate −0.113 0.063 −0.270 −1.798 0.079 Fasting plasma glucose −0.358 0.544 −0.100 −0.658 0.514 Systolic BP 0.003 0.046 0.011 0.057 0.955 Diastolic BP 0.010 0.044 0.046 0.225 0.823 -
E/Em: early diastolic flow velocity/mitral annular early diastolic velocity; DAS: Disease Activity Score; BP: blood pressure; B: regression coefficient; SE: standard error.
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In this issue
Left Ventricular Diastolic Dysfunction in Patients with Dermatomyositis Without Clinically Evident Cardiovascular Disease
