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Research ArticleOMERACT 11

Selecting Magnetic Resonance Imaging (MRI) Outcome Measures for Juvenile Idiopathic Arthritis (JIA) Clinical Trials: First Report of the MRI in JIA Special Interest Group

Robert Hemke, Andrea S. Doria, Nikolay Tzaribachev, Mario Maas, Désirée M.F.M van der Heijde and Marion A.J. van Rossum
The Journal of Rheumatology February 2014, 41 (2) 354-358; DOI: https://doi.org/10.3899/jrheum.131081
Robert Hemke
From the Department of Radiology, Academic Medical Center, University of Amsterdam; Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Diagnostic Imaging, the Hospital for Sick Children, Toronto, Ontario Canada; Department of Pediatric Rheumatology, Center for Rheumatic Diseases, Bad Bramstedt, Germany; Department of Rheumatology, Leiden University Medical Center, Leiden; Department of Pediatric Rheumatology, Amsterdam, the Netherlands.
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  • For correspondence: r.hemke{at}amc.nl
Andrea S. Doria
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Nikolay Tzaribachev
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Mario Maas
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Désirée M.F.M van der Heijde
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Marion A.J. van Rossum
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Abstract

Recent advances in magnetic resonance imaging (MRI) techniques have substantially improved the evaluation of joint pathologies in juvenile idiopathic arthritis (JIA). Because of the current availability of highly effective antirheumatic therapies and the unique and useful features of MRI, there is a growing need for an accurate and reproducible MRI assessment scoring system for JIA, such as the rheumatoid arthritis MRI Scoring (RAMRIS) for patients with rheumatoid arthritis (RA). To effectively evaluate the efficacy of treatment in clinical research trials, we need to develop and validate scoring methods to accurately measure joint outcomes, standardize imaging protocols for data acquisition and interpretation, and create imaging atlases to differentiate physiologic and pathologic joint findings in childhood and adolescence. Such a standardized, validated, JIA-MRI scoring method could be used as an outcome measure in clinical trials.

Key Indexing Terms:
  • MAGNETIC RESONANCE IMAGING
  • JUVENILE IDIOPATHIC ARTHRITIS
  • CHILDREN
  • GUIDELINES
  • SCORING SYSTEMS
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The Journal of Rheumatology
Vol. 41, Issue 2
1 Feb 2014
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Selecting Magnetic Resonance Imaging (MRI) Outcome Measures for Juvenile Idiopathic Arthritis (JIA) Clinical Trials: First Report of the MRI in JIA Special Interest Group
Robert Hemke, Andrea S. Doria, Nikolay Tzaribachev, Mario Maas, Désirée M.F.M van der Heijde, Marion A.J. van Rossum
The Journal of Rheumatology Feb 2014, 41 (2) 354-358; DOI: 10.3899/jrheum.131081

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Selecting Magnetic Resonance Imaging (MRI) Outcome Measures for Juvenile Idiopathic Arthritis (JIA) Clinical Trials: First Report of the MRI in JIA Special Interest Group
Robert Hemke, Andrea S. Doria, Nikolay Tzaribachev, Mario Maas, Désirée M.F.M van der Heijde, Marion A.J. van Rossum
The Journal of Rheumatology Feb 2014, 41 (2) 354-358; DOI: 10.3899/jrheum.131081
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    • Papers presented at the OMERACT 11 Conference, Pinehurst, NC, USA, May 12–17, 2012
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Keywords

MAGNETIC RESONANCE IMAGING
JUVENILE IDIOPATHIC ARTHRITIS
CHILDREN
GUIDELINES
SCORING SYSTEMS

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OMERACT 11

  • Updating the OMERACT Filter at OMERACT 11
  • Updating the OMERACT Filter: Core Areas as a Basis for Defining Core Outcome Sets
  • How to Choose Core Outcome Measurement Sets for Clinical Trials: OMERACT 11 Approves Filter 2.0
Show more OMERACT 11

Imaging and Other Biomarkers

  • Updating the OMERACT Filter at OMERACT 11
  • Updating the OMERACT Filter: Core Areas as a Basis for Defining Core Outcome Sets
  • How to Choose Core Outcome Measurement Sets for Clinical Trials: OMERACT 11 Approves Filter 2.0
Show more Imaging and Other Biomarkers

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Keywords

  • magnetic resonance imaging
  • juvenile idiopathic arthritis
  • CHILDREN
  • guidelines
  • SCORING SYSTEMS

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