Article Figures & Data
Figures
- Figure 1.
Proportions of MTX or ADA + MTX Month 3 and Month 6 responders. The percentages of MTX-treated or ADA + MTX-treated patients exhibiting (A) ACR responses (ACR20/50/70), (B) improvements in DAS28-CRP (improvements > 1.2/1.8), or (C) DAS28-CRP targets (LDA, DAS28-CRP < 3.2; remission, DAS28-CRP < 2.6) at months 3 and 6 (Month 3 responders) or at Month 6 (Month 6 responders). *, **, and *** significantly different between treatment groups at the p < 0.05, 0.01, and 0.001 levels, respectively. Asterisks above columns reflect differences in responder and nonresponder populations across MTX and ADA + MTX groups. Asterisks within columns reflect differences in Month 3 and Month 6 responders across MTX and ADA + MTX groups. MTX: methotrexate; ADA: adalimumab; ACR: American College of Rheumatology; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; LDA: low disease activity.
- Figure 2.
Clinical remission at 1 year in MTX or ADA + MTX Month 3 and Month 6 responders. The percentages of MTX or ADA + MTX-treated patients exhibiting clinical remission (DAS28-CRP < 2.6) at 1 year based on (A–C) ACR responses (ACR20/50/70), (D and E) improvements in DAS28-CRP (> 1.2/1.8), or (F and G) DAS28-CRP targets (LDA, DAS28-CRP < 3.2; remission, DAS28-CRP < 2.6] at months 3 and 6 (Month 3 responders) or at Month 6 (Month 6 responders). A, B, and C indicate outcomes that are significantly different relative to ADA + MTX Month 3 responders, ADA + MTX Month 6 responders, and MTX Month 3 responders, respectively, by OR (95% CI). MTX: methotrexate; ADA: adalimumab; ACR: American College of Rheumatology; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; LDA: low disease activity.
- Figure 3.
Normal functionality at 1 year in MTX or ADA + MTX Month 3 and Month 6 responders. The percentages of MTX or ADA + MTX–treated patients exhibiting normal function (HAQ-DI < 0.5) at 1 year based on (A–C) ACR responses (ACR20/50/70), (D–E) improvements in DAS28-CRP (improvements > 1.2/1.8), or (F–G) DAS28–CRP targets (LDA, DAS28-CRP < 3.2; remission, DAS28-CRP < 2.6) at months 3 and 6 (Month 3 responders) or at Month 6 (Month 6 responders). A, B, and C indicate outcomes that are significantly different relative to ADA + MTX Month 3 responders, ADA + MTX Month 6 responders, and MTX Month 3 responders, respectively, by OR (95% CI). MTX: methotrexate; ADA: adalimumab; ACR: American College of Rheumatology; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; LDA: low disease activity; HAQ-DI: Health Assessment Questionnaire-Disability Index.
- Figure 4.
Radiographic progression in MTX or ADA + MTX Month 3 and Month 6 responders. Mean change in modified total Sharp score (mTSS) from baseline to 1 year in MTX-treated or ADA + MTX-treated patients exhibiting (A) ACR responses (ACR20/50/70), (B) improvements in DAS28-CRP (improvements > 1.2/1.8), or (C) DAS28-CRP targets (LDA, DAS28-CRP < 3.2; remission, DAS28-CRP < 2.6) at months 3 and 6 (Month 3 responders) or at Month 6 (Month 6 responders). MTX: methotrexate; ADA: adalimumab; ACR: American College of Rheumatology; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein.
- Figure 5.
Rapid radiographic progression at 1 year MTX or ADA + MTX Month 3 and Month 6 responders. The percentages of MTX-treated or ADA + MTX-treated patients exhibiting rapid radiographic progression (ΔmTSS > 3) at 1 year based on (A–C) ACR responses (ACR20/50/70), (D–E) improvements in DAS28-CRP (improvements > 1.2/1.8), or (F–G) DAS28-CRP targets (LDA, DAS28-CRP < 3.2; remission, DAS28-CRP < 2.6) at months 3 and 6 (Month 3 responders) or at Month 6 (Month 6 responders). A, B, and C indicate outcomes that are significantly different relative to ADA + MTX Month 3 responders, ADA + MTX Month 6 responders, and MTX Month 3 responders, respectively, by OR (95% CI). MTX: methotrexate; ADA: adalimumab; ACR: American College of Rheumatology; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; mTSS: modified total Sharp score; LDA: low disease activity.
Tables
- Table 1.
Baseline demographics and disease characteristics. All values are mean ± SD, unless otherwise indicated.
Characteristic MTX, n = 200 ADA + MTX, n = 229 Age, yrs 52.8 ± 13.3 51.9 ± 14.1 Female, n (%) 146 (73.0) 160 (69.9) Rheumatoid factor-positive, n (%) 170 (87.2) 186 (83.8) Duration of RA, yrs 0.8 ± 0.9 0.7 ± 0.8 Baseline DMARD use, n (%) 59 (29.5) 73 (31.7) Baseline corticosteroid use, n (%) 68 (34.0) 81 (35.4) DAS28-CRP, range 0–10a 6.3 ± 0.8 6.3 ± 0.9 DAS28-CRP ≥ 5.1, n (%)a 182 (93.8) 199 (90.9) CRP, mg/dl 4.0 ± 4.0 4.0 ± 4.2 SJC (0–66 joints) 22.4 ± 12.0 21.3 ± 11.5 TJC (0–68 joints) 32.0 ± 14.0 30.7 ± 14.6 HAQ-DI (range 0–3) 1.5 ± 0.7 1.5 ± 0.6 mTSS (range 0–398) 22.7 ± 22.7 18.6 ± 20.6 Joint erosion score (0–230)b 14.1 ± 13.7 11.3 ± 12.9 Joint space narrowing score (0–168) 8.6 ± 10.9 7.3 ± 9.4 -
↵a 195 and 220 patients from the MTX and ADA + MTX treatment groups, respectively, had DAS28-CRP values available at baseline.
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↵b p = 0.03 for differences between MTX and ADA + MTX. MTX: methotrexate; ADA: adalimumab; RA: rheumatoid arthritis; DMARD: (nonbiologic) disease-modifying antirheumatic drug; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; SJC: swollen joint count; TJC: tender joint count; HAQ-DI: Health Assessment Questionnaire-Disability Index; mTSS: modified total Sharp score.
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