Article Figures & Data
Tables
- Table 1.
Leptin concentrations (ng/ml) and the relationships with carotid artery plaque (per 1 SD increment) in all RA patients and subgroups. Univariate comparisons of leptin concentrations between subgroups were made using the Mann-Whitney U test and univariate associations of leptin concentrations with plaque in logistic regression models. Major risk factors comprised hypertension, dyslipidemia, smoking, and diabetes2.
Groups Number Concentrations Relationships with Plaque Crude Independent Median (IQR) p p* OR (95% CI) p OR (95% CI) p† All 217 10.2 (5.5–18.5) — — 1.00 (0.99–1.01) 0.4 1.00 (0.99–1.01) 0.3 Population Black 112 12.4 (6.3–21.4) 1.01 (0.99–1.02) 0.4 1.01 (0.99–1.02) 0.5 White 105 8.4 (4.9–14.3) 0.001 0.2 0.96 (0.65–1.43) 0.8 1.00 (0.67–1.50) 1 Age ≥ 50 yrs Yes 169 10.1 (5.5–18.4) 1.00 (0.99–1.01) 0.5 1.00 (0.99–1.01) 0.4 No 48 10.8 (5.2–20.0) 0.9 0.3 1.05 (0.86–1.28) 0.6 1.03 (0.88–1.21) 0.7 Age > 55 yrs Yes 127 9.5 (5.5–17.8) 1.00 (0.99–1.01) 0.9 1.00 (0.99–1.01) 1 No 90 11.6 (5.5–21.2) 0.4 0.1 1.01 (0.99–1.03) 0.4 1.01 (0.99–1.02) 0.5 ≥ 1 major risk factor Yes 151 11.2 (5.7–20.9) 1.53 (0.82–2.84) 0.2 2.75 (1.19–6.37) 0.01 No 58 9.0 (3.8–15.3) 0.03 0.5 1.00 (0.99–1.01) 1 1.00 (0.99–1.01) 0.6 Missing 8 Obesity Yes 64 18.2 (9.5–27.6) 0.99 (0.98–1.01) 0.5 1.00 (0.98–1.01) 0.7 No 147 7.5 (4.6–13.3) < 0.0001 0.9 1.01 (1.00–1.02) 0.09 1.01 (1.00–1.02) 0.1 Missing 6 MetS waist Yes 100 15.0 (8.2–23.3) 0.99 (0.98–1.01) 0.6 1.00 (0.98–1.01) 0.5 No 114 6.9 (4.3–12.4) < 0.0001 0.7 1.01 (0.99–1.02) 0.09 1.01 (1.00–1.02) 0.1 Missing 3 RA duration > 10 yrs Yes 116 9.8 (4.9–17.8) 1.01 (0.99–1.02) 0.2 1.01 (1.00–1.02) 0.2 No 100 10.6 (5.9–20.4) 0.3 0.8 1.00 (0.98–1.01) 0.9 1.00 (0.99–1.01) 1 Missing 1 CDAI > 10 Yes 92 9.4 (5.4–18.3) 1.00 (0.99–1.02) 0.7 1.00 (0.98–1.02) 1 No 124 10.3 (5.2–21.2) 0.3 0.8 1.00 (0.99–1.02) 0.4 1.01 (1.00–1.02) 0.3 Missing 1 ESR > 12 mm/h Yes 106 10.03 (5.9–19.3) 1.05 (0.96–1.13) 0.3 1.05 (0.96–1.14) 0.3 No 105 9.2 (5.2–18.0) 0.4 0.09 1.00 (0.99–1.01) 0.8 1.00 (1.00–1.01) 0.8 Missing 6 Deformed joints Yes 165 10.0 (5.4–17.9) 1.00 (0.99–1.01) 0.7 1.00 (0.99–1.02) 0.7 No 51 11.9 (5.5–22.4) 0.3 0.06 1.00 (0.99–1.02) 0.6 1.01 (0.99–1.03) 0.4 Missing 1 RF-positive Yes 168 9.5 (5.4–18.5) 1.01 (0.99–1.02) 0.1 1.01 (1.00–1.02) 0.2 No 48 12.7 (6.7–19.4) 0.3 0.9 1.00 (0.98–1.01) 0.5 1.00 (0.98–1.01) 0.8 Missing 1 -
↵* p value for associations in age at disease onset, sex, race (except for in models by population grouping), body mass index, glomerular filtration rate, and cardiovascular drug use adjusted linear regression models.
-
↵† p value for associations in Framingham score, race, glomerular filtration rate, body mass index, and C-reactive protein adjusted logistic regression models. Significant associations are shown in bold face. RA: rheumatoid arthritis; IQR: interquartile range; MetS: metabolic syndrome; CDAI: Clinical Disease Activity Index; ESR: erythrocyte sedimentation rate; RF: rheumatoid factor.
-
- Table 2.
Relations of leptin concentrations (1 SD increment) with carotid artery plaque among patients with major conventional cardiovascular risk factors. Associations were determined in logistic regression models.
Adjusted Characteristics OR (95% CI) p None 1.53 (0.82–2.84) 0.2 Framingham score 1.58 (0.83–3.02) 0.2 Framingham score, race 1.78 (0.90–3.52) 0.1 Framingham score, race, CRP 1.80 (0.90–3.58) 0.1 Framingham score, race, CRP, GFR 2.07 (1.00–4.29) 0.04 Framingham score, race, CRP, BMI 2.35 (1.06–5.21) 0.03 Framingham score, race, CRP, GFR, BMI 2.75 (1.19–6.37) 0.01 -
Significant relations are shown in bold face. CRP: C-reactive protein; GFR: glomerular filtration rate, BMI: body mass index.
-
In this issue
